The main objective of the present study was to prepare and evaluate the instant release oral thin films of Flunarizine, in order to
enhance the bioavailability of the drug and to provide rapid onset of action thereby improving patient compliance. The instant release
oral thin films of Flunarizine were prepared by solvent casting method using film forming polymer like Hydroxypropyl Methylcellulose
E-15. The film was evaluated for various physicochemical parameters that include thickness, weight variation, folding endurance,
tensile strength, drug content and in vitro drug release studies. No differences were observed in in vitro dissolution of drug from the
formulated film F1-F9 as the film instantly gets wet by dissolution medium. The drug release for F5 formulations was about 98.1%.
The accelerated stability studies for the optimized film formulations F5 were performed that indicates that the formulated instant
release oral thin films were unaffected after initial and 3 months storage under accelerated conditions.
Design, Development and Evaluation of Instant Release Oral Thin Films of Flunarizine
