scholarly journals MECHANISTIC APPROACH TO THE EFFECTS OF LOW LEVEL LASER IRRADIATION (LLLI) WITH THE GaAlAs DIODE LASER ON THE PRODUCTION OF REACTIVE OXYGEN SPECIES FROM HUMAN NEUTROPHILS AS A MODEL FOR THERAPEUTIC MODALITY AT A CELLULAR LEVEL

LASER THERAPY ◽  
2005 ◽  
Vol 14 (2) ◽  
pp. 75-81 ◽  
Author(s):  
Koh-Jun Suzuki ◽  
Shigeyuki Nakaji ◽  
Terumi Kogawa ◽  
Keiko Kumeta ◽  
Eiko Oka ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Laser Irradiation ◽  
Diode Laser ◽  
Cellular Level ◽  
Therapeutic Modality ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Mechanistic Approach ◽  
Level Laser ◽  
Low Level Laser Irradiation

scholarly journals MECHANISTIC APPROACH TO GaAIAs DIODE LASER EFFECTS ON PRODUCTION OF REACTIVE OXYGEN SPECIES FROM HUMAN NEUTROPHILS AS A MODEL FOR THERAPEUTIC MODALITY AT CELLULAR LEVEL

LASER THERAPY ◽  
1993 ◽  
Vol 5 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Makoto Yamaya ◽  
Chiyuki Shiroto ◽  
Hiroki Kobayashi ◽  
Shinji Naganuma ◽  
Jyuichi Sakamoto ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Diode Laser ◽  
Reactive Oxygen ◽  
Cellular Level ◽  
Therapeutic Modality ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Mechanistic Approach

Low-Level Laser Irradiation Attenuates Production of Reactive Oxygen Species by Human Neutrophils

2003 ◽  
Vol 21 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Yuji Fujimaki ◽  
Tadashi Shimoyama ◽  
Qiang Liu ◽  
Takashi Umeda ◽  
Shigeyuki Nakaji ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Low Level Laser Irradiation

scholarly journals EFFECTS OF LOW LEVEL LASER IRRADIATION (LLLI) WITH 904nm PULSED DIODE LASER ON OSTEOBLASTS: A CONTROLLED TRIAL WITH THE RAT OSTEOBLAST MODEL

LASER THERAPY ◽  
1996 ◽  
Vol 8 (4) ◽  
pp. 223-231 ◽  
Author(s):  
Ki-Suk Kim ◽  
Jung-Ken Kim ◽  
Se-Won Kim ◽  
Jun-Hee Lee ◽  
Yun-Ki Kim ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Diode Laser ◽  
Controlled Trial ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Rat Osteoblast ◽  
Low Level Laser Irradiation

scholarly journals EFFECTS OF LOW INCIDENT LEVELS OF LASER IRRADIATION AND OTHER ENVIRONMENTAL FACTORS ON THE PRODUCTION CAPABILITY OF REACTIVE OXYGEN SPECIES FROM HUMAN NEUTROPHILS

LASER THERAPY ◽  
2005 ◽  
Vol 14 (2) ◽  
pp. 55-65 ◽  
Author(s):  
Ippei Takahashi ◽  
Takashi Umeda ◽  
Takao Oyama ◽  
Sen Shimaya ◽  
Makoto Yaegaki ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Environmental Factors ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Production Capability

scholarly journals EFFECTS OF LOW LEVEL LASER IRRADIATION (LLLI) WITH 904 nm PULSED DIODE LASER ON STAPHYLOCOCCUS AUREUS

LASER THERAPY ◽  
1997 ◽  
Vol 9 (3) ◽  
pp. 121-129 ◽  
Author(s):  
Ki-suk Kim ◽  
Phil-Yeon Lee ◽  
Jun-Hee Lee ◽  
Yun-Ki Kim
Keyword(s):  
Staphylococcus Aureus ◽  
Laser Irradiation ◽  
Diode Laser ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Low Level Laser Irradiation

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

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