Peripheral Giant Cell Granuloma at an Early Age: 2 Year Case Follow-Up

Purpose. Implant therapy plays an important role in contemporary dentistry with high rates of long-term success. However, in recent years, the incidence of peri-implantitis and implant failures has significantly increased. The peripheral giant cell granuloma (PGCG) rarely occurs in peri-implant tissues and it is clinically comparable to the lesions associated with natural teeth. Therefore, the study of possible diseases associated with dental implants plays an important role in order to be able to diagnose and treat these conditions.Materials and Methods. This report described a 60-year-old Caucasian male who presented a reddish-purple pedunculated mass, of about 2 cm in diameter, associated with a dental implant and the adjacent natural tooth.Results. An excisional biopsy was performed and the dental implant was not removed. Histological examination provided the diagnosis of PGCG. After 19-month follow-up, there were no signs of recurrence of peri-implantitis around the implant.Conclusion. The correct diagnosis and appropriate surgical treatment of peri-implant giant cell granuloma are very important for a proper management of the lesion in order to preserve the implant prosthetic rehabilitation and prevent recurrences.

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Peripheral Giant Cell Granuloma Associated With Dental Implants: Clinical Case and Literature Review

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-11-00143 ◽

2012 ◽

Vol 38 (S1) ◽

pp. 527-532 ◽

Cited By ~ 21

Author(s):

Maria A. Peñarrocha-Diago ◽

Juan Cervera-Ballester ◽

Laura Maestre-Ferrín ◽

David Peñarrocha-Oltra

Keyword(s):

Giant Cell ◽

Dental Implants ◽

Histological Study ◽

Complete Resection ◽

Fourth Quadrant ◽

Giant Cell Granuloma ◽

Peripheral Giant Cell Granuloma ◽

Soft Tissue Complication ◽

Fixed Prosthesis

Peripheral giant cell granuloma (PGCG) associated to dental implants is a very infrequent peri-implant soft-tissue complication, with only 11 cases recorded in the literature to date. The present study describes a 54-year-old woman presenting a swelling of the alveolar margin in the fourth quadrant in relation to a fixed prosthesis cemented over implants. Treatment consisted of complete resection of the lesion with implantoplasty of the exposed implant threads. The diagnosis of PGCG was confirmed by histological study, and no relapse has been recorded after 12 months of follow-up.

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Peripheral giant cell granuloma associated with a dental implant

BMC Oral Health ◽

10.1186/s12903-019-0983-2 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Rafaela Carriço Porto Baesso ◽

Maria Carolina de Lima Jacy Monteiro Barki ◽

Rebeca de Souza Azevedo ◽

Karla Bianca Fernandes da Costa Fontes ◽

Débora Lima Pereira ◽

...

Keyword(s):

Giant Cell ◽

Histological Examination ◽

Dental Implant ◽

Excisional Biopsy ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Case Presentation ◽

Peripheral Giant Cell Granuloma ◽

Left Mandible

Abstract Background Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. Case presentation A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence. Conclusions Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.

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Retrospective Clinicopathological Analysis of 65 Peri-Implant Lesions

Medicina ◽

10.3390/medicina57101069 ◽

2021 ◽

Vol 57 (10) ◽

pp. 1069

Author(s):

Amir Shuster ◽

Gal Frenkel ◽

Shlomi Kleinman ◽

Oren Peleg ◽

Clariel Ianculovici ◽

...

Keyword(s):

Giant Cell ◽

Recurrence Rate ◽

Pyogenic Granuloma ◽

Common Finding ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Epithelial Hyperplasia ◽

Clinicopathological Analysis ◽

Peripheral Giant Cell Granuloma

Background and Objectives: Peri-implantitis is a common finding among patients with dental implants. There is no consensus regarding the treatment of this disease, but in many cases, surgical treatment is common practice. A histopathological analysis is not an integral part of suggested protocols. The present study investigated the clinical and histopathological parameters of lesions mimicking peri-implantitis and correlated them with the outcome and follow-up data. Materials and Methods: The study included 65 consecutive biopsies taken from peri-implantitis patients between 2008–2019. Results: The three common diagnoses were fibro-epithelial hyperplasia 20 (30.7%), pyogenic granuloma 16 (24.6%), and peripheral giant cell granuloma 15 (23%). There were 18 cases of recurrent lesions in the study group (27.7%). The recurrence rate was the highest in peripheral giant cell granuloma (8, 12.3%), versus 6% in pyogenic granuloma and fibro-epithelial hyperplasia. These differences in the recurrence rate were statistically significant (p = 0.014). Conclusions: This study emphasizes the necessity of submitting tissue of peri-implantitis cases for histopathological analysis since the more locally aggressive lesions (peripheral giant cell granuloma and pyogenic granuloma), which comprise nearly half of the cases in this study, do not differ in clinical or radiographic characteristics from other peri-implant lesions.

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A rare case of peripheral giant cell granuloma

International Journal of Oral Health Dentistry ◽

10.18231/j.ijohd.2021.028 ◽

2021 ◽

Vol 7 (2) ◽

pp. 138-141

Author(s):

Gursimrat Kaur Brar ◽

S P S Sodhi ◽

Mehak Malhotra ◽

Poshali Goyal

Keyword(s):

Giant Cell ◽

Male Patient ◽

Rare Case ◽

Growth Potential ◽

Biological Behavior ◽

Giant Cell Granuloma ◽

Giant Cell Lesion ◽

Periodontal Membrane ◽

Peripheral Giant Cell Granuloma

Peripheral Giant Cell Granuloma or the so called “Giant Cell Epulis” is the most common oral giant cell lesion. It is described as non-neoplastic, hyperplastic lesion occurring exclusively on gingival/alveolar crest that appears as a overgrowth of tissues, following trauma or irritation arising from periosteum or periodontal membrane. It can be sessile or pedunculated with size usually less than 2cm. Although being uncommon, this lesion carries a lot of uncertainity in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells and its treatment. We hereby report a case of a 49-year old male patient, with peripheral giant cell granuloma in mandibular posterior region, who was successfully treated and is on regular follow up since 6 months.

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Peripheral Giant Cell Granuloma Associated with a Dental Implant: A Case Report and Review of the Literature

Case Reports in Dentistry ◽

10.1155/2015/697673 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Amy Louise Brown ◽

Paulo Camargo de Moraes ◽

Marcelo Sperandio ◽

Andresa Borges Soares ◽

Vera Cavalcanti Araújo ◽

...

Keyword(s):

Giant Cell ◽

Dental Implant ◽

Excisional Biopsy ◽

Giant Cells ◽

Infectious Agents ◽

Giant Cell Granuloma ◽

Review Of The Literature ◽

Peripheral Giant Cell Granuloma ◽

Foreign Body Reactions

The peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion commonly caused by local irritation. This report describes a 46-year-old Caucasian male who presented with a PGCG associated with a dental implant. The dental implant was originally placed in August 2012. Ten months later, the patient presented with a well-circumscribed lesion associated with and covering the implant, at which time the lesion was excised. Four months later, due to recurrence of the lesion, a deeper and wider excisional biopsy with curettage of the adjacent bone was performed. No evidence of recurrence has been reported after 12 months of follow-up. Immunohistochemistry, using the antibody CD68, was performed to investigate the origin of the multinucleated giant cells, with their immunophenotype being similar to those of other giant cell lesions, including central giant cell granuloma, foreign-body reactions, and granulomatous reactions to infectious agents.

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Peripheral giant cell granuloma: a case repo

International Journal of Dental Research ◽

10.14419/ijdr.v4i2.6359 ◽

2016 ◽

Vol 4 (2) ◽

pp. 44

Author(s):

Saad Shahnawaz Ahmed ◽

Hira Zaman ◽

Fahad Bin Abrar ◽

Sadia Khalid

Keyword(s):

Giant Cell ◽

Stromal Cells ◽

Unknown Origin ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Cell Hyperplasia ◽

Peripheral Giant Cell Granuloma ◽

Good Healing ◽

Chronic Trauma

Peripheral giant cell granuloma (PGCG) is a common benign gingival lesion in the oral cavity of unknown origin, believed to be stimulated by local irritation or chronic trauma. It is also known as giant cell epulis, giant cell reparative granuloma, or giant-cell hyperplasia, presenting as purplish-red soft tissue nodule clinically and histologically consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This case report describes a 40 year old male previously reported with peripheral giant cell granuloma 2 years back which on excision reoccurred after 3-4 months and persistently growing since then. The gingival lesion between his maxillary central incisors was excised and the Biopsy specimen sent in 10% formalin to histopathological lab and was diagnosed as PGCG. There was good healing of tissue of the surgical site during the 9 months follow-up.

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