Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

Lan Zhang; Cong Shen; Jin Chu; Ruyi Zhang; Yali Li; Lin Li

doi:10.7150/ijbs.6232

Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

International Journal of Biological Sciences ◽

10.7150/ijbs.6232 ◽

2014 ◽

Vol 10 (2) ◽

pp. 181-191 ◽

Cited By ~ 39

Author(s):

Lan Zhang ◽

Cong Shen ◽

Jin Chu ◽

Ruyi Zhang ◽

Yali Li ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Amyloid Burden ◽

Model Of Alzheimer’S Disease ◽

Β Amyloid ◽

Bace 1

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Naphthalene Monoimide Derivative Ameliorates Amyloid Burden and Cognitive Decline in a Transgenic Mouse Model of Alzheimer's Disease

Advanced Therapeutics ◽

10.1002/adtp.202000225 ◽

2021 ◽

pp. 2000225

Author(s):

Sourav Samanta ◽

Kolla Rajasekhar ◽

Madhu Ramesh ◽

Natarajan Arul Murugan ◽

Shadab Alam ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Cognitive Decline ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Amyloid Burden ◽

Model Of Alzheimer’S Disease

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WBQ5187, a Multitarget Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease and Modulates Cerebral β-Amyloid, Gliosis, cAMP Levels, and Neurodegeneration

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00409 ◽

2019 ◽

Vol 10 (12) ◽

pp. 4787-4799

Author(s):

Zhiren Wang ◽

Mengru Cao ◽

Hongling Xiang ◽

Wei Wang ◽

Xing Feng ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Model Of Alzheimer’S Disease ◽

Β Amyloid ◽

Camp Levels

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Voxel-Based Analysis of Amyloid-Burden Measured with [11C]PiB PET in a Double Transgenic Mouse Model of Alzheimer’s Disease

Molecular Imaging and Biology ◽

10.1007/s11307-013-0625-z ◽

2013 ◽

Vol 15 (5) ◽

pp. 576-584 ◽

Cited By ~ 11

Author(s):

Boris von Reutern ◽

Barbara Grünecker ◽

Behrooz H. Yousefi ◽

Gjermund Henriksen ◽

Michael Czisch ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Amyloid Burden ◽

Model Of Alzheimer’S Disease ◽

Double Transgenic Mouse

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Fibrillar β-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer’s disease

Neuroscience ◽

10.1016/s0306-4522(01)00115-4 ◽

2001 ◽

Vol 104 (3) ◽

pp. 609-613 ◽

Cited By ~ 85

Author(s):

Y Matsuoka ◽

M Picciano ◽

J La Francois ◽

K Duff

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Oxidative Damage ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Model Of Alzheimer’S Disease ◽

Β Amyloid

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Apolipoprotein E Dose-Dependent Modulation of β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

Journal of Molecular Neuroscience ◽

10.1385/jmn:23:3:255 ◽

2004 ◽

Vol 23 (3) ◽

pp. 255-262 ◽

Cited By ~ 30

Author(s):

Ronald B. DeMattos

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Apolipoprotein E ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Amyloid Deposition ◽

Model Of Alzheimer’S Disease ◽

Β Amyloid ◽

Dose Dependent

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Statistical aspects of quantitative image analysis of β-amyloid in the APPV717F transgenic mouse model of Alzheimer's disease

Journal of Neuroscience Methods ◽

10.1016/s0165-0270(01)00381-8 ◽

2001 ◽

Vol 108 (2) ◽

pp. 145-152 ◽

Cited By ~ 12

Author(s):

Cindy E. Fishman ◽

David J. Cummins ◽

Kelly R. Bales ◽

Cynthia A. DeLong ◽

Michail A. Esterman ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Image Analysis ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Quantitative Image Analysis ◽

Model Of Alzheimer’S Disease ◽

Quantitative Image ◽

Β Amyloid

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P1-065: Oxidative load regulates amyloid burden in vitro and in vivo in an APP X PS1 transgenic mouse model of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.651 ◽

2008 ◽

Vol 4 ◽

pp. T225-T225

Author(s):

Fahd Choudhry ◽

Paul T. Francis ◽

David R. Howlett ◽

Jill R.C. Richardson ◽

Robert J. Williams

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Amyloid Burden ◽

Model Of Alzheimer’S Disease ◽

Oxidative Load

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High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer’s disease

Aging Cell ◽

10.1111/j.1474-9726.2012.00845.x ◽

2012 ◽

Vol 11 (5) ◽

pp. 810-822 ◽

Cited By ~ 30

Author(s):

Harun N. Noristani ◽

Alexei Verkhratsky ◽

José J. Rodríguez

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Model Of Alzheimer’S Disease ◽

Β Amyloid ◽

Triple Transgenic Mouse

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β-Amyloid Plaques Induce Neuritic Dystrophy of Nitric Oxide-Producing Neurons in a Transgenic Mouse Model of Alzheimer's Disease

Experimental Neurology ◽

10.1006/exnr.2000.7598 ◽

2001 ◽

Vol 168 (2) ◽

pp. 203-212 ◽

Cited By ~ 20

Author(s):

Joseph Quinn ◽

Forrest Davis ◽

William R. Woodward ◽

Felix Eckenstein

Keyword(s):

Nitric Oxide ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Amyloid Plaques ◽

Transgenic Mouse Model ◽

Model Of Alzheimer’S Disease ◽

Neuritic Dystrophy ◽

Β Amyloid

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Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

Journal of Neuroinflammation ◽

10.1186/1742-2094-7-57 ◽

2010 ◽

Vol 7 (1) ◽

pp. 57 ◽

Cited By ~ 12

Author(s):

S Sakura Minami ◽

Elkhansa Sidahmed ◽

Saba Aid ◽

Mika Shimoji ◽

Takako Niikura ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Passive Immunization ◽

Transgenic Mouse Model ◽

Amyloid Burden ◽

Model Of Alzheimer’S Disease ◽

Aβ Amyloid

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