scholarly journals Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage

2021 ◽  
Vol 18 (3) ◽  
pp. 639-645
Author(s):  
Cheng Zhi ◽  
Shulian Zeng ◽  
Yuan Chen ◽  
Degui Liao ◽  
Miaoling Lai ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Experimental Model ◽  
Inflammatory Mediators ◽  
Neuronal Apoptosis ◽  
Neural Function

Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage

2020 ◽  
Vol 29 (1) ◽  
pp. 104483 ◽  
Author(s):  
Xi-chang Liu ◽  
Chang-zhu Wu ◽  
Xiao-fei Hu ◽  
Ting-ling Wang ◽  
Xiao-ping Jin ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
Neurological Deficits

Up-Regulation of Glis2 Involves in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats

2014 ◽  
Vol 35 (3) ◽  
pp. 345-354 ◽  
Author(s):  
Kaifu Ke ◽  
Yan Song ◽  
Jiabing Shen ◽  
Mu Niu ◽  
Haiyan Zhang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
Adult Rats

Cab45s inhibits neuronal apoptosis following intracerebral hemorrhage in adult rats

2018 ◽  
Vol 143 ◽  
pp. 36-44 ◽  
Author(s):  
Jiabing Shen ◽  
Tingting Zhou ◽  
Haizhen Li ◽  
Wanyan Li ◽  
Shuyao Wang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
Adult Rats

scholarly journals Evaluation of Neuronal Apoptosis Precursors in an Experimental Model of Acute Normovolemic Hemodilution

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108366
Author(s):  
Fabrício O. Frazilio ◽  
Denise Aya Otsuki ◽  
Jessica Noel-Morgan ◽  
Jessica Ruivo Maximino ◽  
Gabriela Pintar Oliveira ◽  
...  
Keyword(s):  
Experimental Model ◽  
Neuronal Apoptosis ◽  
Acute Normovolemic Hemodilution ◽  
Normovolemic Hemodilution

scholarly journals Ginsenoside Rg3 Improves Recovery from Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation

Molecules ◽  
2017 ◽  
Vol 22 (1) ◽  
pp. 122 ◽  
Author(s):  
Dong-Kyu Kim ◽  
Ki-Jung Kweon ◽  
Pyungsoo Kim ◽  
Hee-Jung Kim ◽  
Sung-Soo Kim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Mediators ◽  
Neuronal Apoptosis ◽  
Microglial Activation ◽  
Ginsenoside Rg3 ◽  
Cord Injury

scholarly journals TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Shengpan Chen ◽  
Jianhua Peng ◽  
Prativa Sherchan ◽  
Yongjie Ma ◽  
Sishi Xiang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
Akt Pathway

scholarly journals The Possible Inhibition Effect of Lycium barbarum Polysaccharides on Rat Intracerebral Hemorrhage Secondary Neuronal Apoptosis through Intervening Endogenous/Exogenous Pathways of Apoptosis

2020 ◽  
Vol 9 (02) ◽  
pp. 106-114
Author(s):  
Yourui Zou ◽  
ShengYu Sun ◽  
Usama Ilyas Sharif ◽  
Abdul Wasie ◽  
Hui Ma
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
B Cell Lymphoma ◽  
Neurological Function ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Sham Operation ◽  
Lycium Barbarum ◽  
Inhibition Effect ◽  
The Impact ◽  
Lycium Barbarum Polysaccharides

Abstract Objective The aim of this study was to explore the inhibition effect and possible mechanism of Lycium barbarum polysaccharides (LBP) on rat intracerebral hemorrhage (ICH) secondary neuronal apoptosis. Materials and Methods High-, medium-, and low-dose LBP (50, 100, and 200 mg•kg) and nimodipine (10 mg•kg) groups were given once daily by 15-day gavage before operation, while the sham operation and ICH groups were given the equal volume of saline. An ICH model was established by autologous blood injection and the neurological function in each group was scored at 4, 8, 12, 24, and 48 hours after modeling. Furthermore, terminal deoxynucleotidyl transferase dUTP nick end labeling analysis was performed to detect neuronal apoptosis, while western blot, immunohistochemistry, and real-time-polymerase chain reaction were used to study the influence of LBP on ICH secondary neuronal apoptosis. Results The neurological function score was significantly decreased after ICH, and the intervention effect of a single drug was not evident. The apoptotic nerve cells increased significantly in the ICH group but decreased considerably in the LBP groups. Furthermore, tumor necrosis factor alpha (TNF-α) expression decreased significantly, while B-cell lymphoma 2 expression increased substantially in the high- and medium-dose LBP groups compared with ICH group, suggesting that LBP could reduce the effect of ICH. However, the impact of LBP did not correlate positively with the dose. Conclusion The application of LBP may not significantly improve neurological function after ICH, but it can inhibit rat ICH secondary neuronal apoptosis.

scholarly journals BTEB2 Prevents Neuronal Apoptosis via Promoting Bad Phosphorylation in Rat Intracerebral Hemorrhage Model

2014 ◽  
Vol 55 (1) ◽  
pp. 206-216 ◽  
Author(s):  
Xiaojuan Liu ◽  
Damin Yuan ◽  
Xiaoke Nie ◽  
Jianhong Shen ◽  
Yaohua Yan ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis

scholarly journals Effects of homocysteine-induced endoplasmic reticulum protein on endoplasmic reticulum stress, autophagy, and neuronal apoptosis following intracerebral hemorrhage

IBRO Reports ◽  
2020 ◽  
Vol 9 ◽  
pp. 207-217
Author(s):  
Hui Wu ◽  
Jinglei Wang ◽  
Maohong Cao ◽  
Jingjing Liang ◽  
Dan Wu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
Endoplasmic Reticulum Protein

USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage

2015 ◽  
Vol 58 (1) ◽  
pp. 16-27 ◽  
Author(s):  
Zhiwei Xu ◽  
Xiaohong Li ◽  
Jianping Chen ◽  
Jianmei Zhao ◽  
Jun Wang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Neuronal Apoptosis ◽  
Deubiquitinating Enzyme
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