scholarly journals HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions

2022 ◽  
Vol 13 (1) ◽  
pp. 1-14
Author(s):  
Pan Wang ◽  
Sheng Gong ◽  
Bin Liao ◽  
Jinyu Pan ◽  
Junwei Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Glioma Cell ◽  
Cell Dedifferentiation ◽  
Hypoxic Conditions

Netrin-like domain of sFRP4, a Wnt antagonist inhibits stemness, metastatic and invasive properties by specifically blocking MMP-2 in cancer stem cells from human glioma cell line U87MG

2021 ◽  
pp. 112912
Author(s):  
Ishmat Ara Yasmin ◽  
S. Mohana Sundaram ◽  
Anasuya Banerjee ◽  
Lavanya Varier ◽  
Arun Dharmarajan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Human Glioma ◽  
Human Glioma Cell Line ◽  
Human Glioma Cell

Detection of Cancer Stem Cells from the C6 Glioma Cell Line

2009 ◽  
Vol 37 (2) ◽  
pp. 503-510 ◽  
Author(s):  
X-D Zhou ◽  
X-Y Wang ◽  
F-J Qu ◽  
Y-H Zhong ◽  
X-D Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
C6 Glioma ◽  
C6 Glioma Cell

Glioma Cell Lines: Role of Cancer Stem Cells

2011 ◽  
pp. 205-212
Author(s):  
John R. Ohlfest ◽  
Stacy A. Decker
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cell Lines

A novel approach to the identification and enrichment of cancer stem cells from a cultured human glioma cell line

2009 ◽  
Vol 281 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Zhi-hua Zhou ◽  
Yi-fang Ping ◽  
Shi-cang Yu ◽  
Liang Yi ◽  
Xiao-hong Yao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Human Glioma ◽  
Human Glioma Cell Line ◽  
Human Glioma Cell ◽  
Novel Approach

scholarly journals Differentiation of cancer stem cells into erythroblasts in the presence of CoCl2

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kazuki Kumon ◽  
Said M. Afify ◽  
Ghmkin Hassan ◽  
Shunsuke Ueno ◽  
Sadia Monzur ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Microenvironment ◽  
Cancer Stem Cells ◽  
Malignant Tumors ◽  
Multilineage Differentiation ◽  
Differentiation Potential ◽  
Hypoxic Conditions ◽  
Induced Pluripotent ◽  
Insight Into ◽  
Runx1 Expression

AbstractCancer stem cells (CSCs) are subpopulations in the malignant tumors that show self-renewal and multilineage differentiation into tumor microenvironment components that drive tumor growth and heterogeneity. In previous studies, our group succeeded in producing a CSC model by treating mouse induced pluripotent stem cells. In the current study, we investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for 1 to 7 days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed by RT-qPCR, Western blotting and flow cytometry together with Wright-Giemsa staining and immunocytochemistry. CoCl2 induced significant accumulation of HIF-1α changing the morphology of miPS-LLCcm cells while the morphological change was apparently not related to differentiation. The expression of VEGFR2 and CD31 was suppressed while Runx1 expression was upregulated. The population with hematopoietic markers CD34+ and c-kit+ was immunologically detected in the presence of CoCl2. Additionally, high expression of CD34 and, a marker for erythroblasts, TER-119, was observed. Therefore, CSCs were suggested to differentiate into erythroblasts and erythrocytes under hypoxia. This differentiation potential of CSCs could provide new insight into the tumor microenvironment elucidating tumor heterogenicity.

Circadian properties of cancer stem cells in glioma cell cultures and tumorspheres

2014 ◽  
Vol 345 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Vishal Premdev Sharma ◽  
Nathan Thomas Anderson ◽  
Michael Eric Geusz
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Cultures ◽  
Glioma Cell

Doxycyclin Inhibits Breast Cancer Stem Cells under Hypoxic Conditions

The Breast ◽  
2017 ◽  
Vol 36 ◽  
pp. S42
Author(s):  
Almaz Akhunzianov ◽  
Olesya Yapparova ◽  
Regina Miftakhova ◽  
Albert Rizvanov
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Hypoxic Conditions

scholarly journals Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: Towards targeting of cancer stem cells with phytochemicals

2010 ◽  
Vol 293 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Dunne Fong ◽  
Arthur Yeh ◽  
Rotem Naftalovich ◽  
Theresa Hyejeong Choi ◽  
Marion M. Chan
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Line ◽  
Glioma Cell ◽  
Side Population ◽  
Glioma Cell Line ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Rat C6 Glioma
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