scholarly journals Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXL-targeting small molecule kinase inhibitor

Theranostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1918-1936
Author(s):  
Ho Jin Lee ◽  
Phuong Chi Pham ◽  
Honglan Pei ◽  
Bumhee Lim ◽  
Seung Yeob Hyun ◽  
...  
Keyword(s):  
Growth Factor ◽  
Small Molecule ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Insulin Like Growth Factor ◽  
Small Molecule Kinase Inhibitor

Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis

2008 ◽  
Vol 44 (11) ◽  
pp. 1577-1586 ◽  
Author(s):  
Christian Moser ◽  
Philipp Schachtschneider ◽  
Sven A. Lang ◽  
Andreas Gaumann ◽  
Akira Mori ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factor ◽  
Small Molecule ◽  
Kinase Inhibitor ◽  
Cancer Growth ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Small Molecule Kinase Inhibitor ◽  
Growth Factor I

scholarly journals Preclinical and first‐in‐human phase I studies of KW ‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity

2016 ◽  
Vol 107 (4) ◽  
pp. 499-506 ◽  
Author(s):  
Gary K. Schwartz ◽  
Mark A. Dickson ◽  
Patricia M. LoRusso ◽  
Edward A. Sausville ◽  
Yoshimi Maekawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Phase I ◽  
Insulin Receptor ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Insulin Like Growth Factor ◽  
Phase I Studies ◽  
Receptor Selectivity
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