Comparison of survival outcomes between modified radical mastectomy and breast conserving surgery in early breast cancer patients

Purpose: This study aims to assess survival rates in early breast cancer patients treated by Conservative breast therapy (CBT), including radiotherapy, compared to those treated by modified radical mastectomy (MRM) alone. Methods: The South Egypt Cancer Institute and the Assiut University Oncology Department patients’ records, from January 2010 to December 2017, were searched for T1-2N0-1M0 breast cancer patients treated by CBT or MRM. Patients who didn’t receive chemotherapy were excluded to reduce the treatment variation. Results: The five-year locoregional disease free survival (LRDFS) was 97.3% for the CBT patients was and 98.0% for the MRM patients (P=.675). The five-year distant disease free survival (DDFS) was 93.6% for CBS and 85.7% for MRM (P=0.033). The DFS was 91.9% for the BCT patients and 85.3% for the MRM patients (P=0.045). The five-year OS was 98.2% for the CBT patients and 94.3% for the MRM patients, (P=0.02). By Cox regression analysis, the CBT resulted in significantly better OS, (p=0.018) and the (HR=0.350, 95% CI 0.146-0.837). The adjusted OS, estimated by the propensity-score based weights, remained superior in CBT than in MRM patients (p < 0.001). Conclusion: CBT resulted in better DDFS, DFS and OS than MRM. Future randomized trials are needed to confirm these findings and determine the cause.

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A Comparison between Breast-Conserving Surgery and Modified Radical Mastectomy Concerning the Female Sexual Function in Breast Cancer Patients under 50 Years of Age

Turkish Journal of Oncology ◽

10.5505/tjo.2019.2135 ◽

2020 ◽

Author(s):

Bekir Hakan BAKKAL

Keyword(s):

Breast Cancer ◽

Sexual Function ◽

Cancer Patients ◽

Radical Mastectomy ◽

Breast Conserving Surgery ◽

Female Sexual Function ◽

Breast Cancer Patients ◽

Modified Radical Mastectomy

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Effect of breast-conserving surgery and modified radical mastectomy on operation index, symptom checklist-90 score and prognosis in patients with early breast cancer

Medicine ◽

10.1097/md.0000000000019279 ◽

2020 ◽

Vol 99 (11) ◽

pp. e19279

Author(s):

Han Qiu ◽

Wen-Hui Xu ◽

Jun Kong ◽

Xiao-Jun Ding ◽

Deng-Feng Chen

Keyword(s):

Breast Cancer ◽

Early Breast Cancer ◽

Radical Mastectomy ◽

Breast Conserving Surgery ◽

Symptom Checklist ◽

Modified Radical Mastectomy

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Adequate locoregional treatment for early breast cancer may prevent secondary dissemination.

Journal of Clinical Oncology ◽

10.1200/jco.1995.13.12.2869 ◽

1995 ◽

Vol 13 (12) ◽

pp. 2869-2878 ◽

Cited By ~ 159

Author(s):

R Arriagada ◽

L E Rutqvist ◽

A Mattsson ◽

A Kramar ◽

S Rotstein

Keyword(s):

Breast Cancer ◽

Local Recurrence ◽

Cancer Patients ◽

Early Breast Cancer ◽

Distant Metastasis ◽

Preoperative Radiotherapy ◽

Postoperative Radiotherapy ◽

Radical Mastectomy ◽

Breast Cancer Surgery ◽

Breast Cancer Patients

PURPOSE To analyze different events that determine event-free survival (EFS) in a randomized trial on adjuvant radiotherapy in early breast cancer patients with more than 15 years of follow-up evaluation. PATIENTS AND METHODS The trial included 960 patients with a unilateral, operable breast cancer. Surgery consisted of a modified radical mastectomy. The trial compared three arms, as follows: preoperative radiotherapy, postoperative radiotherapy, and no adjuvant treatment. Events were analyzed by a competing-risk approach. A proportional hazards multiple regression model was used to analyze the effects of radiotherapy on the risk of distant metastasis. Similar analyses were performed separately for node-negative [N(-)] and node-positive [N(+)] patients in the two groups that did not include preoperative radiotherapy. RESULTS Radiotherapy produced a fivefold decrease of the risk of local recurrence (P < .0001). In N(+) patients, postoperative radiotherapy decreased the risk of distant dissemination (relative risk, 0.63). When local recurrence was introduced in the model as a time-dependent covariate, this factor was predictive of distant dissemination (P < .0001) and nullified the effect of postoperative radiotherapy. This finding suggests that the decrease of distant metastases was related to the prevention of local recurrence. A similar effect was found in models that used overall survival as an end point. CONCLUSION This study shows that postmastectomy radiotherapy in N(+) breast cancer patients may decrease the distant metastasis rate by preventing local recurrences and thus avoiding secondary dissemination.

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