scholarly journals Peer Review #1 of "Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population (v0.2)"

2017 ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peer Review ◽  
Russian Population ◽  
Polymorphic Markers

scholarly journals Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3414 ◽  
Author(s):  
Aleksey G. Nikitin ◽  
Viktor Y. Potapov ◽  
Olga I. Brovkina ◽  
Ekaterina O. Koksharova ◽  
Dmitry S. Khodyrev ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cell Function ◽  
Russian Population ◽  
Polymorphic Markers ◽  
Nucleotide Polymorphisms ◽  
Insulin Synthesis ◽  
Link Type

Background The association of type 2 diabetes mellitus (T2DM) with the KCNJ11, CDKAL1, SLC30A8, CDKN2B, and FTO genes in the Russian population has not been well studied. In this study, we analysed the population frequencies of polymorphic markers of these genes. Methods The study included 862 patients with T2DM and 443 control subjects of Russian origin. All subjects were genotyped for 10 single nucleotide polymorphisms (SNPs) of the genes using real-time PCR (TaqMan assays). HOMA-IR and HOMA-β were used to measure insulin resistance and β-cell secretory function, respectively. Results The analysis of the frequency distribution of polymorphic markers for genes KCNJ11, CDKAL1, SLC30A8 and CDKN2B showed statistically significant associations with T2DM in the Russian population. The association between the FTO gene and T2DM was not statistically significant. The polymorphic markers rs5219 of the KCNJ11 gene, rs13266634 of the SLC30A8 gene, rs10811661 of the CDKN2B gene and rs9465871, rs7756992 and rs10946398 of the CDKAL1 gene showed a significant association with impaired glucose metabolism or impaired β-cell function. Conclusion In the Russian population, genes, which affect insulin synthesis and secretion in the β-cells of the pancreas, play a central role in the development of T2DM.

scholarly journals Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population

2020 ◽  
Vol 22 (5) ◽  
pp. 436-443
Author(s):  
Tatiana P. Bardymova ◽  
Maksim V. Mistiakov ◽  
Galina P. Yagelskaya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Postmenopausal Women ◽  
Bone Tissue ◽  
Bone Remodeling ◽  
Comparison Group ◽  
Russian Population ◽  
Type 2 Dm

BACKGROUND: In most countries, there is a rapid increase in the population of patients with type 2 Diabetes Mellitus (DM). Bone changes in postmenopausal women with type 2 DM are associated with increased bone mineral density (BMD). The study of metabolic processes in bone tissue in comorbid pathology in different ethnic groups is continuing. AIMS: To study the concentration of markers of bone remodeling and indicators of BMD in postmenopausal women with type 2 DM of the Buryat population. MATERIALS AND METHODS: Thirty-nine postmenopausal women with type 2 DM (22 Russian population and 17 Buryat population) were examined. The comparison group consisted of 42 postmenopausal women (21 Russian population and 21 - Buryat population). The study of BMD in the lumbar spine (L1-L4), the femoral neck (Neck), and the proximal femur (Total hip) was performed using dual-energy X-ray absorptiometry. Parameters of osteocalcin (OC), type 1 N-terminal procollagen propeptide (P1NP), C-terminal telopeptides of type I collagen (-Cross laps), 25(OH) vitamin D and ionized calcium were evaluated. RESULTS: The presented study revealed a simultaneous increase in osteosynthesis: ОС (p=0.048) and P1NP (p=0.016) and in the bone resorption marker -Cross laps (p=0.020) accompanied by the absence of changes in BMD in women with type 2 DM in the postmenopausal period of the Buryat population relative to women with type 2 DM in the postmenopausal state of the Russian population. A decrease in osteosynthesis parameters (ОC, p=0.021; P1NP, p=0.029) with an increase in BMD L1-L4 (p=0.024) and BMD Total hip (p=0.039) in postmenopausal women with type 2 DM of the Buryat population was found relative to the women of the Buryat population in comparison group. CONCLUSIONS: The state of bone tissue in postmenopausal women with type 2 DM of the Buryat population is characterized by the activation of bone remodeling processes.

scholarly journals Associations of Polymorphic Markers Aluins/Deli>D Ace T-786C Gene Enos3 in Diabetic Nefropate Progressing for Type 2 Diabetes Mellitus

2020 ◽  
Vol 11 (4) ◽  
pp. 6028-6032
Author(s):  
Ozimboy O Jabbarov ◽  
Botir T Daminov ◽  
Kodirjon T Boboev ◽  
Laylo D Tursunova ◽  
Maxsuma X Tashpulatova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Kidney Function ◽  
Polymorphic Markers ◽  
Patients With Diabetes ◽  
Diabetes Nephropathy ◽  
The Relationship

In the current study, the development of diabetic nephropathy identified the relationship between the polymeric marker of AC genes and the NS3 gene. One hundred twenty-nine patients with type 2 diabetes were tried. Patients in the principle gathering: 65 people with diabetes nephropathy preserved kidney function (33 patients), and kidney function weakness (32 patients), 64 patients with Diabetes were enduring more than 10-20 years, diabetic nephropathy preserved the chain of genotyping polymers carries out kidney function (31 patients). The study showed a link between eNOS3 genes in the development of diabetic nephropathy in Type 2 diabetes patients, supported by the ACE gene.

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