scholarly journals Peer Review #2 of "The identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes (v0.2)"

2019 ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Peer Review ◽  
Gene Signature ◽  
Childhood Onset ◽  
Critical Pathway ◽  
Onset Type

scholarly journals The identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6343 ◽  
Author(s):  
Keren Jia ◽  
Yingcheng Wu ◽  
Jingyi Ju ◽  
Liyang Wang ◽  
Lili Shi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Signature ◽  
Gene Expression Omnibus ◽  
Marker Genes ◽  
Healthy Children ◽  
Newly Diagnosed ◽  
Ppi Network ◽  
Childhood Onset ◽  
Critical Pathway

In general, type 2 diabetes (T2D) usually occurs in middle-aged and elderly people. However, the incidence of childhood-onset T2D has increased all across the globe. Therefore, it is very important to determine the molecular and genetic mechanisms of childhood-onset T2D. In this study, the dataset GSE9006 was downloaded from the GEO (Gene Expression Omnibus database); it includes 24 healthy children, 43 children with newly diagnosed Type 1 diabetes (T1D), and 12 children with newly diagnosed T2D. These data were used for differentially expressed genes (DGEs) analysis and weighted co-expression network analysis (WGCNA). We identified 192 up-regulated genes and 329 down-regulated genes by performing DEGs analysis. By performing WGGNA, we found that blue module (539 genes) was highly correlated to cyan module (97 genes). Gene ontology (GO) and pathway enrichment analyses were performed to figure out the functions and related pathways of genes, which were identified in the results of DEGs and WGCNA. Genes with conspicuous logFC and in the high correlated modules were input into GeneMANIA, which is a plugin of Cytoscape application. Thus, we constructed the protein-protein interaction (PPI) network (92 nodes and 254 pairs). Eventually, we analyzed the transcription factors and references related to genes with conspicuous logFC or high-degree genes, which were present in both the modules of WGCNA and PPI network. Current research shows that EGR1 and NAMPT can be used as marker genes for childhood-onset T2D. Gestational diabetes and chronic inflammation are risk factors that lead to the development of childhood-onset T2D.

Inequalities in glycemic control in childhood onset type 2 diabetes in England and Wales—A national population‐based longitudinal study

2019 ◽  
Vol 20 (7) ◽  
pp. 821-831
Author(s):  
Amal R. Khanolkar ◽  
Rakesh Amin ◽  
David Taylor‐Robinson ◽  
Russell M. Viner ◽  
Justin Warner ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Longitudinal Study ◽  
Glycemic Control ◽  
Population Based ◽  
Childhood Onset ◽  
England And Wales ◽  
Onset Type ◽  
National Population

scholarly journals Prenatal, Obstetric and Perinatal Factors Associated With the Development of Childhood-Onset Type 2 Diabetes

2018 ◽  
Vol 42 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Julie Halipchuk ◽  
Beverley Temple ◽  
Allison Dart ◽  
Donna Martin ◽  
Elizabeth A.C. Sellers
Keyword(s):  
Type 2 Diabetes ◽  
Perinatal Factors ◽  
Childhood Onset ◽  
Factors Associated ◽  
Onset Type

scholarly journals Survey of Current Medical Treatments for Childhood-Onset Type 2 Diabetes Mellitus in Japan

2005 ◽  
Vol 14 (2) ◽  
pp. 65-75 ◽  
Author(s):  
Shigetaka Sugihara ◽  
Nozomu Sasaki ◽  
Hitoshi Kohno ◽  
Shin Amemiya ◽  
Toshiaki Tanaka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Current Medical ◽  
Childhood Onset ◽  
Medical Treatments ◽  
Onset Type

Analysis of weight at birth and at diagnosis of childhood-onset type 2 diabetes mellitus in Japan

2008 ◽  
Vol 9 (4pt1) ◽  
pp. 285-290 ◽  
Author(s):  
Shigetaka Sugihara ◽  
Nozomu Sasaki ◽  
Shin Amemiya ◽  
Hitoshi Kohno ◽  
Toshiaki Tanaka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Childhood Onset ◽  
Onset Type
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