scholarly journals Article Commentary: Kynurenine Pathway Pathologies: Do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

2013 ◽  
Vol 6s1 ◽  
pp. IJTR.S11193 ◽  
Author(s):  
Adele Blankfield
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Neuropsychiatric Symptoms ◽  
Protein Energy Malnutrition ◽  
Chronic Fatigue ◽  
Kynurenine Pathway ◽  
Metabolic Dysfunction ◽  
Fatigue Syndrome ◽  
Inflammatory Conditions ◽  
Protein Energy ◽  
Definition Of

Chronic fatigue syndrome (CFS) and fibromyalgia (FM) appear to meet the criteria of a tryptophan-kynurenine pathway disorder with potential neuroimmunological sequelae. Aspects of some of the putative precipitating factors have been previously outlined. 2 , 3 An analysis of the areas of metabolic dysfunction will focus on future directions for research and management. The definition of dual tryptophan pathways has increased the understanding of the mind-body, body-mind dichotomy. The serotonergic pathway highlights the primary (endogenous) psychiatric disorders. The up-regulation of the kynurenine pathway by physical illnesses can cause neuropathic and immunological disorders 1 associated with secondary neuropsychiatric symptoms. Tryptophan and nicotinamide deficiencies fall within the protein energy malnutrition (PEM) spectrum. They can arise if the kynurenine pathway is stressed by primary or secondary inflammatory conditions and the consequent imbalance of available catabolic/anabolic substrates may adversely influence convalescent phase efficiency. The replacement of depleted or reduced NAD+ levels and other cofactors can perhaps improve the clinical management of these disorders.

Chronic Fatigue Immune Dysfunction Syndrome: An Epidemic?

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 804-804
Author(s):  
MUDR ALEŠ KMINEK ◽  
MUDR IVO SIMUNEK
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Children And Adolescents ◽  
Immune Dysfunction ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Fatigue Syndrome ◽  
Definition Of ◽  
Mild Fever

To the Editor.— We read with great interest the article "Chronic Fatigue in Adolescents" by Smith et al in the August 1991 issue.1 We appreciate the statement by the authors that "the CDC-recommended criteria for case definition of the chronic fatigue syndrome (CFS) were developed mainly from adult populations and may not be appropriate for children and adolescents." We have studied children suffering from unexplained fatigue, mild fever, nonexudative pharyngitis, lymphadenopathia, etc, since 1987, ie, prior to publication of CDC-recommended criteria of CFS.2

U.S. Case Definition of Chronic Fatigue Syndrome

1999 ◽  
Vol 5 (3-4) ◽  
pp. 3-33 ◽  
Author(s):  
Leonard A. Jason ◽  
Caroline P. King ◽  
Judith A. Richman ◽  
Renee R. Taylor ◽  
Susan R. Torres ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Fatigue Syndrome ◽  
Definition Of

scholarly journals Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort

2021 ◽  
Vol 11 (6) ◽  
pp. 760
Author(s):  
J Antonio González-Hermosillo ◽  
Jhanea Patricia Martínez-López ◽  
Sofía Antonieta Carrillo-Lampón ◽  
Dayanara Ruiz-Ojeda ◽  
Sharon Herrera-Ramírez ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Clinical Features ◽  
Length Of Hospital Stay ◽  
Chronic Fatigue ◽  
Median Number ◽  
Myalgic Encephalomyelitis ◽  
Common Symptom ◽  
Fatigue Syndrome ◽  
Potential Link ◽  
Definition Of

The aim of this study was to describe the clinical evolution during 6 months of follow-up of adults recovered from COVID-19. We tried to determine how many met the definition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A total of 130 patients (51.0 ± 14 years, 34.6% female) were enrolled. Symptoms were common, participants reported a median number of 9 (IQR 5–14) symptoms. Fatigue was the most common symptom (61/130; 46.9%). Patients with fatigue were older 53.9 ± 13.5 years compared with 48.5 ± 13.3 years in those without fatigue (p = 0.02) and had a longer length of hospital stay, 17 ± 14 days vs. 13 ± 10 days (p = 0.04). There was no difference in other comorbidities between patients with fatigue and those without it, and no association between COVID-19 severity and fatigue. After multivariate adjustment of all baseline clinical features, only age 40 to 50 years old was positively associated with fatigue, OR 2.5 (95% CI 1.05–6.05) p = 0.03. In our survey, only 17 (13%) patients met the Institute of Medicine’s criteria for “systemic exertion intolerance disease,” the new name of ME/CFS. In conclusion, in some patients, the features of post-acute COVID-19 syndrome overlap with the clinical features of ME/CFS.

scholarly journals Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

2021 ◽  
Author(s):  
Hawraa Al-Jassas ◽  
Hussein Al-Hakeim ◽  
Michael Maes
Keyword(s):  
Immune Response ◽  
Chronic Fatigue Syndrome ◽  
Oxygen Saturation ◽  
Immune Activation ◽  
Rating Scales ◽  
Neuropsychiatric Symptoms ◽  
Chronic Fatigue ◽  
Sem Analysis ◽  
Lung Lesions ◽  
Fatigue Syndrome

Background: COVID-19 is associated with neuropsychiatric symptoms including increased depressive, anxiety and chronic fatigue-syndrome (CFS)-like physiosomatic (previously known as psychosomatic) symptoms.Aims: To delineate the associations between affective and CFS-like symptoms in COVID-19 and chest CT-scan anomalies (CCTAs), oxygen saturation (SpO2), interleukin (IL)-6, IL-10, C-Reactive Protein (CRP), albumin, calcium, magnesium, soluble angiotensin converting enzyme (ACE2) and soluble advanced glycation products (sRAGEs).Method: The above biomarkers were assessed in 60 COVID-19 patients and 30 heathy controls who had measurements of the Hamilton Depression (HDRS) and Anxiety (HAM-A) and the Fibromyalgia and Chronic Fatigue (FF) Rating Scales. Results: Partial Least Squares-SEM analysis showed that reliable latent vectors could be extracted from a) key depressive and anxiety and physiosomatic symptoms (the physio-affective or PA-core), b) IL-6, IL-10, CRP, albumin, calcium, and sRAGEs (the immune response core); and c) different CCTAs (including ground glass opacities, consolidation, and crazy paving) and lowered SpO2% (lung lesions). PLS showed that 70.0% of the variance in the PA-core was explained by the regression on the immune response and lung lesions latent vectors. Moreover, one common “infection-immune-inflammatory (III) core” underpins pneumonia-associated CCTAs, lowered SpO2 and immune activation, and this III core explains 70% of the variance in the PA core, and a relevant part of the variance in melancholia, insomnia, and neurocognitive symptoms.Discussion: Acute SARS-CoV-2 infection is accompanied by lung lesions and lowered SpO2 which both may cause activated immune-inflammatory pathways, which mediate the effects of the former on the PA-core and other neuropsychiatric symptoms due to SARS-CoV-2 infection.

A Constructive Debate With the CDC on the Empirical Case Definition of Chronic Fatigue Syndrome

2010 ◽  
Vol 20 (4) ◽  
pp. 251-256 ◽  
Author(s):  
Leonard A. Jason ◽  
Nicole Porter ◽  
Molly Brown ◽  
Abigail Brown ◽  
Meredyth Evans
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Fatigue Syndrome ◽  
Definition Of

scholarly journals Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety and chronic fatigue syndrome-like symptoms due to COVID-19: a nomothetic network approach.

2021 ◽  
Author(s):  
Hawraa Al-Jassas ◽  
Hussein K Al-Hakeim ◽  
Michael Maes
Keyword(s):  
Immune Response ◽  
Chronic Fatigue Syndrome ◽  
Oxygen Saturation ◽  
Immune Activation ◽  
Rating Scales ◽  
Neuropsychiatric Symptoms ◽  
Chronic Fatigue ◽  
Sem Analysis ◽  
Lung Lesions ◽  
Fatigue Syndrome

Background: COVID-19 is associated with neuropsychiatric symptoms including increased depressive, anxiety and chronic fatigue-syndrome (CFS)-like physiosomatic (previously known as psychosomatic) symptoms. Aims: To delineate the associations between affective and CFS-like symptoms in COVID-19 and chest CT-scan anomalies (CCTAs), oxygen saturation (SpO2), interleukin (IL)-6, IL-10, C-Reactive Protein (CRP), albumin, calcium, magnesium, soluble angiotensin converting enzyme (ACE2) and soluble advanced glycation products (sRAGEs). Method: The above biomarkers were assessed in 60 COVID-19 patients and 30 heathy controls who had measurements of the Hamilton Depression (HDRS) and Anxiety (HAM-A) and the Fibromyalgia and Chronic Fatigue (FF) Rating Scales. Results: Partial Least Squares-SEM analysis showed that reliable latent vectors could be extracted from a) key depressive and anxiety and physiosomatic symptoms (the physio-affective or PA-core), b) IL-6, IL-10, CRP, albumin, calcium, and sRAGEs (the immune response core); and c) different CCTAs (including ground glass opacities, consolidation, and crazy paving) and lowered SpO2% (lung lesions). PLS showed that 70.0% of the variance in the PA-core was explained by the regression on the immune response and lung lesions latent vectors. Moreover, one common infection-immune-inflammatory (III) core underpins pneumonia-associated CCTAs, lowered SpO2 and immune activation, and this III core explains 70% of the variance in the PA core, and a relevant part of the variance in melancholia, insomnia, and neurocognitive symptoms. Discussion: Acute SARS-CoV-2 infection is accompanied by lung lesions and lowered SpO2 which both may cause activated immune-inflammatory pathways, which mediate the effects of the former on the PA-core and other neuropsychiatric symptoms due to SARS-CoV-2 infection.

Chronic Fatigue Syndrome: An Immunological Perspective

1998 ◽  
Vol 32 (4) ◽  
pp. 523-527 ◽  
Author(s):  
Uté Vollmer-Conna ◽  
Andrew Lloyd ◽  
Ian Hickie ◽  
Denis Wakefield
Keyword(s):  
Central Nervous System ◽  
Chronic Fatigue Syndrome ◽  
Cytokine Production ◽  
Neuropsychiatric Symptoms ◽  
Chronic Fatigue ◽  
Cytokine Release ◽  
Fatigue Syndrome ◽  
Cytokine Levels ◽  
The Brain ◽  
Neural Dysfunction

Objective: The aim of this study is to review research examining an immunological basis for chronic fatigue syndrome (CFS) and to discuss how a disturbance in immunity could produce central nervous system (CNS)-mediated symptoms. Method: Data relevant to the hypothesis that abnormal cytokine release plays a role in the pathogenesis of CFS are reviewed as well as recent evidence relating to potential mechanisms by which immune products may enter the brain and produce a disturbance in CNS processes. Results: Examinations of cytokine levels in patients with CFS have produced inconclusive results. Recent evidence suggests that abnormal release of cytokines within the CNS may cause neural dysfunction by a variety of complex mechanisms. Conclusion: Neuropsychiatric symptoms in patients with CFS may be more closely related to disordered cytokine production by glial cells within the CNS than to circulating cytokines. This possibility is discussed in the context of unresolved issues in the pathogenesis of CFS.

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