Comparative Fracture Risk During Osteoporosis Drug Holidays After Long-Term Risedronate Versus Alendronate Therapy

2022 ◽  
Author(s):  
Kaleen N. Hayes ◽  
Kevin A. Brown ◽  
Angela M. Cheung ◽  
Sandra A. Kim ◽  
David N. Juurlink ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Osteoporosis Drug

scholarly journals AB0618 GLUCOCORTICOID INDUCED OSTEOPOROSIS PREVENTION IN THE OUTPATIENT RHEUMATOLOGY CLINIC

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1343.2-1344
Author(s):  
Z. Vaghaiwalla ◽  
G. Kaeley
Keyword(s):  
Vitamin D ◽  
Fracture Risk ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Osteoporosis Prevention ◽  
Osteoporosis Medication ◽  
Rheumatology Clinic ◽  
Dexa Scan ◽  
Audit Cycle

Background:Patients with rheumatic disease are at risk of developing glucocorticoid induced osteoporosis (GIOP) as many are prescribed systemic oral glucocorticoids as an adjunct to their maintenance therapy. Based on the 2017 ACR Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis, a good practice recommendation exists that “initial clinical fracture risk assessment should be performed as soon as possible, but at least within six months of the initiation of long term glucocorticoid treatment.1” Long-term glucocorticoid use is defined by duration of 3 months or greater. Fracture risk assessment should include dual energy-ray absorptiometry (DEXA) scan. Patients on greater than or equal to 2.5 mg of prednisone should be treated with an optimal dose of calcium and vitamin D and may benefit from oral bisphosphonate as primary prevention against GIOP if their fracture risk is moderate to high.1Objectives:The aim of this Quality Improvement Project is to assess the current status of provider implementation of GIOP recommendations in the rheumatology clinic. Ultimate goal is to improve osteoporosis prevention in the rheumatology clinic.Methods:We conducted a retrospective chart review of 60 patients in two outpatient rheumatology clinics. Clinic 1 follows patients with lower socioeconomic status and Clinic 2 follows patients with higher socioeconomics. Inclusion criteria were patients on long-term glucocorticoid use, defined as at least 3 months of corticosteroid use of at least 2.5 mg prednisone daily, as well as age less than 65. Females aged 65 or older were omitted to prevent overlap of the United States Preventative Taskforce recommendation for all women ≥ 65 years to be screened for osteoporosis with DEXA scans.2 DEXA scan orders, calcium and vitamin D prescriptions, and osteoporosis medication prescriptions were abstracted. After baseline data obtained, intervention of education of the rheumatology fellows and faculty, and internal medicine residents in the guidelines for GIOP prevention was implemented. In addition, a smartphrase in the electronic medical record was created for provider use when treating patients on chronic corticosteroids. Subsequently, two audit cycles were completed for retrospective chart review.Results:Upon completion of second audit cycle, there was no change in percentage of DEXA scan orders at Clinic 1, however there was a 10% overall improvement in DEXA scan orders in the Clinic 2.In terms of Calcium and Vitamin D prescriptions, there was an overall improvement in both clinics of 19.7% and 13.3% in Clinics 1 and 2 respectfully after the second audit cycle.Additionally, there was a 3.4% increase in osteoporosis medication prescriptions overall subsequent to the second audit cycle in Clinic 1. However in Clinic 2 there was an overall decrease in osteoporosis medication prescriptions of 6.6%.Clinic 1Prior to AuditAudit cycle 1Audit cycle 2Patient percentage without DEXA scan orders30%33.30%30%Patient percentage without Vitamin D/Calcium orders26.40%8.30%6.70%Patient percentage with osteoporosis medication orders23.30%8.30%26.70%Clinic 2Patient percentage without DEXA scan orders50%37.00%40%Patient percentage without Vitamin D/Calcium orders30%26.00%16.70%Patient percentage with osteoporosis medication orders23.30%11.10%16.70%Conclusion:Overall, the results of the intervention were strongest for improvements in Vitamin D and Calcium orders in both clinics. Improvements in DEXA scan orders and osteoporosis medications were present in Clinic 2 and not present in Clinic 1. This reveals continued efforts and education of providers need to be made for improvement in bone health monitoring.References:[1]Buckley, Lenore, et al. “2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.” Arthritis & Rheumatology, vol. 69, no. 8, June 2017, pp. 1521–1537., doi:10.1002/art.40137.[2]Final Recommendation Statement: Osteoporosis to Prevent Fractures: Screening. U.S. Preventive Services Task Force. July 2019.Disclosure of Interests:None declared.

Long-Term Fracture Risk Among Children With Asthma: A Population-Based Study

2004 ◽  
Vol 20 (4) ◽  
pp. 564-570 ◽  
Author(s):  
L Joseph Melton ◽  
Ashok Patel ◽  
Sara J Achenbach ◽  
Ann L Oberg ◽  
John W Yunginger
Keyword(s):  
Fracture Risk ◽  
Population Based ◽  
Population Based Study ◽  
Children With Asthma

Acute and Long-Term Increase in Fracture Risk after Hospitalization for Vertebral Fracture

2001 ◽  
Vol 12 (3) ◽  
pp. 207-214 ◽  
Author(s):  
O. Johnell ◽  
A. Oden ◽  
F. Caulin ◽  
J. A. Kanis
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk

scholarly journals Kidney function and its association to imminent, short- and long-term fracture risk—a longitudinal study in older women

2019 ◽  
Vol 31 (1) ◽  
pp. 97-107
Author(s):  
L. Malmgren ◽  
F.E. McGuigan ◽  
A. Christensson ◽  
K.E. Akesson
Keyword(s):  
Longitudinal Study ◽  
Fracture Risk ◽  
Older Women ◽  
Kidney Function ◽  
Short And Long Term

Developing a Fracture Risk Clinical Assessment Protocol for Long-Term Care: A Modified Delphi Consensus Process

2020 ◽  
Author(s):  
Caitlin McArthur ◽  
Loretta Hillier ◽  
George Ioannidis ◽  
Jonathan D. Adachi ◽  
Lora Giangregorio ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Clinical Assessment ◽  
Long Term Care ◽  
Delphi Consensus ◽  
Consensus Process ◽  
Term Care ◽  
Assessment Protocol ◽  
Modified Delphi

scholarly journals Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

2020 ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C. Kiefte-de Jong ◽  
Suzanne C. van Dijk ◽  
Karin M.A. Swart ◽  
Kim J. Ploegmakers ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Fracture Risk ◽  
Vitamin B12 ◽  
Long Term Effects ◽  
Vitamin B12 Supplementation

Long-term effects of functional impairment on fracture risk and mortality in postmenopausal women

2018 ◽  
Vol 29 (9) ◽  
pp. 2111-2120 ◽  
Author(s):  
T. Rikkonen ◽  
K. Poole ◽  
J. Sirola ◽  
R. Sund ◽  
R. Honkanen ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Postmenopausal Women ◽  
Functional Impairment ◽  
Long Term Effects
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