Comparative study of single dose pre-emptive pregabalin vs. Placebo for post-operative pain relief in middle ear surgery

Background and aims: Palonosetron 5HT 3 antagonist have been evaluated in delayed chemotherapy induced nausea and vomiting but its antiemetic efficacy after middle ear surgery is less clear which is high risk for post operative nausea and vomiting.( PONV). This study aimed to evaluate whether Palonosetron conferred any advantage over Granisetron in terms of duration of prophylaxis and its effect on the incidence and severity of PONV in patients undergoing middle ear surgeries (MES) when used as single dose prophylactic antiemetic. Methods: One hundred ASA I and II patients of either gender aged 18 to 60 were randomly assigned into group P (Palonosetron n=50) or group G( Granisetron n=50), by computerised randomisation. Analysis was done in terms of incidence and severity of nausea, vomiting and rescue antiemetic usage till 72 hours of surgery. Results: During 72 hours, group P had more number of complete responders than in group G (56% vs. 34%). This difference was more significant after 24hours. 50% of patients in group G as against 28% in group required rescue antiemetic. Conclusion: Single dose prophylactic Palonosetron 0.075 mg and 2.5 mg Granisetron conferred similar protection against postoperative nausea and vomiting for initial six hours postoperatively but Palonosetron was more effective than Granisetron for long term prophylaxis over 72 hours against PONV after MES without significant adverse effects.

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A randomized prospective trial to compare four different ear packs following permeatal middle ear surgery

The Journal of Laryngology & Otology ◽

10.1017/s0022215100140149 ◽

1998 ◽

Vol 112 (2) ◽

pp. 140-144 ◽

Cited By ~ 13

Author(s):

H. Zeitoun ◽

G. S. Sandhu ◽

M. Kuo ◽

M. Macnamara

Keyword(s):

Prospective Study ◽

Middle Ear ◽

Prospective Trial ◽

Middle Ear Surgery ◽

Ear Surgery ◽

Post Operative Pain ◽

Significant Difference ◽

Different Types ◽

Randomized Prospective Trial ◽

Previous Training

AbstractSurgeons choice of an ear pack is dictated by availability, previous training and personal preference. There has been no recent prospective study evaluating the use of different types of ear packs. This randomized prospective study compares the use of BIPP impregnated ribbon gauze (Aurum), Pope wicks (Xomed-Teace), silastic sheeting (Dow Corning) and tri-adcortyl ointment (Squibb) as an ear dressing following ‘clear’ middle ear procedures via a permeatal approach. The results showed that there was no statistically significant difference in post-operative pain and discomfort experienced, neither was there any significant difference regarding the otolaryngologist's assessment of the degree of canal granulation, stenosis or discharge with the above named packs. This study concludes that non-traditional dressings such as tri-adcortyl ointment or simply a thin silastic sheet placed on the drum are no worse than time honoured BIPP. They have, as well, the advantage of being well-tolerated by the patients.

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A comparative study between magnesium sulphate and dexmedetomidine for deliberate hypotension during middle ear surgery

Egyptian Journal of Anaesthesia ◽

10.1016/j.egja.2011.07.008 ◽

2011 ◽

Vol 27 (4) ◽

pp. 227-232 ◽

Cited By ~ 4

Author(s):

Ossama H. Aboushanab ◽

Ahmed M. El-Shaarawy ◽

Ahmed M. Omar ◽

Hisham H. Abdelwahab

Keyword(s):

Comparative Study ◽

Middle Ear ◽

Magnesium Sulphate ◽

Middle Ear Surgery ◽

Ear Surgery ◽

Deliberate Hypotension

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Is Gelfoam Necessary for Middle Ear Surgery: A Comparative Study of the Results of Tympanoplasty With and Without Gelfoam in the Middle Ear

Indian Journal of Otolaryngology and Head & Neck Surgery ◽

10.1007/s12070-020-02057-8 ◽

2020 ◽

Author(s):

Kranti Bhavana ◽

Rohit Kumar Jha ◽

Somak Majumdar ◽

Nikhil

Keyword(s):

Comparative Study ◽

Middle Ear ◽

Middle Ear Surgery ◽

Ear Surgery

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A comparative study of endoscopic assisted versus conventional middle ear and mastoid surgery at a tertiary care teaching hospital

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20214823 ◽

2021 ◽

Author(s):

Jitendra Kumar Sharma ◽

Sushma Mahich ◽

Navneet Mathur

Keyword(s):

Comparative Study ◽

Middle Ear ◽

Operative Time ◽

Middle Ear Surgery ◽

Wide Field ◽

Time Duration ◽

Ear Surgery ◽

Significant Difference ◽

Duration Of Surgery ◽

Mastoid Surgery

Background: Objectives were to compare outcomes, intra operative visualization and operative time duration in endoscopic assisted vs conventional middle ear and mastoid surgery.Methods: This prospective comparative study was conducted in 50 patients; among them 25 cases were of endoscope assisted middle ear surgery and 25 cases with conventional microscopic middle ear surgery. A 4 mm diameter, 18 cm long rigid, zero-degree endoscope and operating microscope was used. Primary outcomes include mean average pre and post operative air-bone (A-B) gap, hearing thresholds, intra operative visualization and duration of surgery.Results: Mean A-B gap closure for endoscopic assisted tympanoplasty was 12.76±6.00 dB, while it was 8.38±5.78 dB for non-endoscopic assisted tympanoplasty. The results were comparative. Mean intra-operative time duration for endoscopic assisted tympanoplasty was 70.23±4.17 min, while it was 77±9.80 min for non-endoscopic assisted tympanoplasty with statically significant difference between both groups (p=0.03). Graft uptake rate for endoscopic assisted tympanoplasty was 92.31% while it was 84.62% for non-endoscopic assisted tympanoplasty. Residual cholesteatoma remnant on endoscopy was found in 43.66% cases out of 12 mastoidectomy cases performed via endoscopic assistance.Conclusions: The endoscope can be successfully applied to ear surgery for most of the ear procedures with a reasonable success rate both in terms of perforation closure and hearing improvement and with minimal exposure. Wide-field zero, 30 or 70° endoscope sallow visualization of hidden anatomic spaces and working around corners i.e., epitympanum, hypotympanum and retro tympanum for safe removal of cholesteatoma.

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