scholarly journals System of label-free three-dimensional optical coherence tomography angiography with high sensitivity and motion contrast and its applications in brain science

2016 ◽  
Vol 65 (15) ◽  
pp. 154201
Author(s):  
Zhou Li-Ping ◽  
Li Pei ◽  
Pan Cong ◽  
Guo Li ◽  
Ding Zhi-Hua ◽  
...  

Optical coherence tomography angiography (OCTA) is a new imaging method providing the assessment of retinal and choroidal vasculature without a contrast agent. In this angiography type, the vascular networks have been visualized in detail though detecting motion contrast of erythrocytes in the vessel, using serial optical coherence tomography B-scans. Currently, OCTA findings of many retinal diseases have been reported.



Author(s):  
Pei Li ◽  
Liping Zhou ◽  
Yang Ni ◽  
Yuxuan Cheng ◽  
Zhihua Ding ◽  
...  


2011 ◽  
Vol 91 (11) ◽  
pp. 1596-1604 ◽  
Author(s):  
Jeremiah Wierwille ◽  
Peter M Andrews ◽  
Maristela L Onozato ◽  
James Jiang ◽  
Alex Cable ◽  
...  


2017 ◽  
Vol 97 (2) ◽  
Author(s):  
Peter M. Maloca ◽  
Richard F. Spaide ◽  
Simon Rothenbuehler ◽  
Hendrik P. N. Scholl ◽  
Tjebo Heeren ◽  
...  


2015 ◽  
Vol 20 (11) ◽  
pp. 116004 ◽  
Author(s):  
Yuxuan Cheng ◽  
Li Guo ◽  
Cong Pan ◽  
Tongtong Lu ◽  
Tianyu Hong ◽  
...  


2021 ◽  
pp. 153537022110265
Author(s):  
David Le ◽  
Taeyoon Son ◽  
Xincheng Yao

Optical coherence tomography angiography (OCTA) offers a noninvasive label-free solution for imaging retinal vasculatures at the capillary level resolution. In principle, improved resolution implies a better chance to reveal subtle microvascular distortions associated with eye diseases that are asymptomatic in early stages. However, massive screening requires experienced clinicians to manually examine retinal images, which may result in human error and hinder objective screening. Recently, quantitative OCTA features have been developed to standardize and document retinal vascular changes. The feasibility of using quantitative OCTA features for machine learning classification of different retinopathies has been demonstrated. Deep learning-based applications have also been explored for automatic OCTA image analysis and disease classification. In this article, we summarize recent developments of quantitative OCTA features, machine learning image analysis, and classification.



2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Eleni Nikolopoulou ◽  
Massimo Lorusso ◽  
Luisa Micelli Ferrari ◽  
Maria Vittoria Cicinelli ◽  
Francesco Bandello ◽  
...  

Introduction. Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases. Purpose. To determine the sensitivity and specificity of OCTA in detecting CNV secondary to nAMD, compared to fluorescein angiography (FA) and indocyanine green angiography (ICGA). Methods. Prospective observational study. Patients with suspected nAMD were recruited between May and December 2016. Patients underwent FA, ICGA, spectral domain OCT, and OCTA (AngioVue, Optovue, Inc.). Sensitivity and specificity of FA, with or without ICGA, were assessed and compared with OCTA. Results. Seventy eyes of 70 consecutive patients were included: 32 eyes (45.7%) with type I CNV, 8 eyes (11.4%) with type II CNV, 4 eyes (5.7%) with type III CNV, 6 eyes (8.6%) with mixed type I and type II CNV, and 20 eyes (28.6%) with no CNV. Sensitivity of OCTA was 88% and specificity was 90%. Concordance between FA/ICGA and OCTA was very good (0,91; range 0,81–1,00). Conclusions. OCTA showed high sensitivity and specificity for detection of CNV. Concordance between OCTA and gold-standard dye-based techniques was excellent. OCTA may represent a first-line noninvasive method for the diagnosis of nAMD.



2020 ◽  
Vol 13 (10) ◽  
Author(s):  
Enrico Borrelli ◽  
Riccardo Sacconi ◽  
Lea Querques ◽  
Marco Battista ◽  
Francesco Bandello ◽  
...  


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