scholarly journals Decision letter: Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

2017 ◽  
Keyword(s):  
Fast Spiking ◽  
Habitual Behavior ◽  
Circuit Output

scholarly journals Author response: Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

2017 ◽  
Author(s):  
Justin K O'Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen Ade ◽  
...  
Keyword(s):  
Author Response ◽  
Fast Spiking ◽  
Habitual Behavior ◽  
Circuit Output

scholarly journals Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Justin K O'Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen Ade ◽  
...  
Keyword(s):  
Behavioral Adaptation ◽  
Single Class ◽  
Gamma Frequency ◽  
Dependent Behavior ◽  
Selective Modulation ◽  
Lever Pressing ◽  
Fast Spiking ◽  
Habitual Behavior ◽  
Circuit Output

Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior.

scholarly journals Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex

2013 ◽  
Vol 109 (11) ◽  
pp. 2781-2792 ◽  
Author(s):  
Emilie Campanac ◽  
Dax A. Hoffman
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Input Resistance ◽  
Compensatory Mechanism ◽  
Cocaine Exposure ◽  
Membrane Excitability ◽  
Chronic Cocaine ◽  
Fast Spiking ◽  
Circuit Output

The medial prefrontal cortex plays a key role in cocaine addiction. However, how chronic cocaine exposure affects cortical networks remains unclear. Most studies have focused on layer 5 pyramidal neurons (the circuit output), while the response of local GABAergic interneurons to cocaine remains poorly understood. Here, we recorded from fast-spiking interneurons (FS-IN) after repeated cocaine exposure and found altered membrane excitability. After cocaine withdrawal, FS-IN showed an increase in the number of spikes evoked by positive current injection, increased input resistance, and decreased hyperpolarization-activated current. We also observed a reduction in miniature excitatory postsynaptic currents, whereas miniature inhibitory postsynaptic current activity was unaffected. We show that, in animals with cocaine history, dopamine receptor D2 activation is less effective in increasing FS-IN intrinsic excitability. Interestingly, these alterations are only observed 1 wk or more after the last cocaine exposure. This suggests that the dampening of D2-receptor-mediated response may be a compensatory mechanism to rein down the excitability of FS-IN.

scholarly journals Striatal fast-spiking interneurons drive habitual behavior

2017 ◽  
Author(s):  
Justin K. O’Hare ◽  
Haofang Li ◽  
Namsoo Kim ◽  
Erin Gaidis ◽  
Kristen K. Ade ◽  
...  
Keyword(s):  
Habit Formation ◽  
Behavioral Adaptation ◽  
Single Class ◽  
Gamma Frequency ◽  
Dependent Behavior ◽  
Selective Modulation ◽  
Lever Pressing ◽  
Fast Spiking ◽  
Habitual Behavior

AbstractHabit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habitual behavior. Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are more excitable in habitual mice compared to goal-directed and acute chemogenetic inhibition of FSIs in DLS prevents the expression of habitual lever pressing. In vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on their firing patterns; FSIs inhibit most SPNs but paradoxically promote the activity of a subset displaying high fractions of gamma-frequency spiking. These results establish a microcircuit mechanism for habits and provide a new example of how interneurons mediate experience-dependent behavior.

Female rats express habitual behavior earlier in operant training than males.

2019 ◽  
Vol 133 (1) ◽  
pp. 110-120 ◽  
Author(s):  
Hannah L. Schoenberg ◽  
Emily X. Sola ◽  
Ellen Seyller ◽  
Michael Kelberman ◽  
Donna J. Toufexis
Keyword(s):  
Female Rats ◽  
Habitual Behavior ◽  
Operant Training

Bionomic of Anopheles sp. in Merauke District, Papua

SCISCITATIO ◽  
2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Djoko Rahardjo ◽  
Vinsa Cantya Prakasita ◽  
Marlen Aviati Sarah Pepiana
Keyword(s):  
Qualitative Data ◽  
Feeding Habits ◽  
Feeding Activity ◽  
Feeding Habit ◽  
Blood Type ◽  
Insect Repellent ◽  
Mosquito Repellent ◽  
Mosquito Nets ◽  
Community Behavior ◽  
Habitual Behavior

Malaria is known as an endemic disease that often causes death in Indonesia, especially in Papua. The malaria cases control in Papua has not been carried on based on data studies, therefore bionomic of Anopheles sp is important to be studied. Bionomics data are consisted of breeding places, resting places and feeding habits are from direct observation. Interviews and questionnaires were conducted to gain information about respondent behavior. Descriptive and qualitative data were then analyzed. The breeding places of Anopheles sp. were mostly found in swampy areas. Based on the feeding habit, the feeding activity of Anopheles sp. inside the house has only one biting peak at 23.00-02.00 WIT, while outside the house, biting peaks occurred at 21.00-22.00 WIT and 00.00-01.00 WIT. Resting place data shown that Anopheles sp. mostly found in piles of clothes and shoe racks. Recorded factors that affect mosquitos bionomics are temperature, humidity, salinity, pH, community behavior, and the presence of livestock. Environmental factors (temperature, humidity, salinity, and pH), habitual behavior of host (3M action, the habit of using insect repellent, mosquito repellent, and mosquito nets), the presence of livestock, and the type of bait blood type affect mosquito activity.

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