scholarly journals Author response: Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

2020 ◽  
Author(s):  
Branden R Nelson ◽  
Rebecca D Hodge ◽  
Ray AM Daza ◽  
Prem Prakash Tripathi ◽  
Sebastian J Arnold ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Author Response ◽  
Intermediate Progenitors

scholarly journals Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Branden R Nelson ◽  
Rebecca D Hodge ◽  
Ray AM Daza ◽  
Prem Prakash Tripathi ◽  
Sebastian J Arnold ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Lineage Tracing ◽  
Cell Contact ◽  
Genetic Lineage ◽  
Multiphoton Imaging ◽  
Intermediate Progenitors ◽  
Dynamic Cell ◽  
Cell Cell

The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of mouse DG development, testing decades old static models of DG formation with molecular identification, genetic-lineage tracing, and mutant analyses. We found novel progenitor migrations, timings, dynamic cell-cell interactions, signaling activities, and routes underlie mosaic DG formation. Intermediate progenitors (IPs, Tbr2+) pioneered migrations, supporting and guiding later emigrating NSCs (Sox9+) through multiple transient zones prior to converging at the nascent outer adult niche in a dynamic settling process, generating all prenatal and postnatal granule neurons in defined spatiotemporal order. IPs (Dll1+) extensively targeted contacts to mitotic NSCs (Notch active), revealing a substrate for cell-cell contact support during migrations, a developmental feature maintained in adults. Mouse DG formation shares conserved features of human neocortical expansion.

Differential Notch signalling distinguishes neural stem cells from intermediate progenitors

Nature ◽  
2007 ◽  
Vol 449 (7160) ◽  
pp. 351-355 ◽  
Author(s):  
Ken-ichi Mizutani ◽  
Keejung Yoon ◽  
Louis Dang ◽  
Akinori Tokunaga ◽  
Nicholas Gaiano
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signalling ◽  
Intermediate Progenitors

scholarly journals The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

Neuron ◽  
2013 ◽  
Vol 78 (4) ◽  
pp. 658-672 ◽  
Author(s):  
Guangnan Li ◽  
Li Fang ◽  
Gloria Fernández ◽  
Samuel J. Pleasure
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Ventral Hippocampus ◽  
Adult Neural Stem Cells ◽  
Embryonic Origin

scholarly journals Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

2012 ◽  
Vol 31 (2) ◽  
pp. 307-314 ◽  
Author(s):  
YUKI AKAZAWA ◽  
TAKAMASA KITAMURA ◽  
YURI FUJIHARA ◽  
YOSHITAKA YOSHIMURA ◽  
MASATO MITOME ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Dentate Gyrus ◽  
Hippocampal Dentate Gyrus ◽  
Adult Neural Stem Cells

scholarly journals Tbr2 Is Essential for Hippocampal Lineage Progression from Neural Stem Cells to Intermediate Progenitors and Neurons

2012 ◽  
Vol 32 (18) ◽  
pp. 6275-6287 ◽  
Author(s):  
R. D. Hodge ◽  
B. R. Nelson ◽  
R. J. Kahoud ◽  
R. Yang ◽  
K. E. Mussar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Intermediate Progenitors

scholarly journals Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development

2011 ◽  
Vol 356 (2) ◽  
pp. 553-565 ◽  
Author(s):  
Gudrun Viktorin ◽  
Nadia Riebli ◽  
Anna Popkova ◽  
Angela Giangrande ◽  
Heinrich Reichert
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Brain Development ◽  
Glial Cells ◽  
Central Complex ◽  
Intermediate Progenitors ◽  
Drosophila Brain
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