scholarly journals Obstructing Trachea Tumor: Myoepithelial Carcinoma about a Case

2021 ◽  
Vol 9 (3) ◽  
pp. 45
Author(s):  
Amine Kessab ◽  
Adil Zegmout ◽  
Mohammed Reda El Ochi ◽  
Wafaa El Omari ◽  
Abderrahmane Rhorfi ◽  
...  
Keyword(s):  
Postoperative Radiotherapy ◽  
Malignant Neoplasm ◽  
Immunohistochemical Analysis ◽  
Myoepithelial Carcinoma ◽  
Rare Tumor ◽  
Hospital Emergency ◽  
Operative Specimen ◽  
Hospital Emergency Room ◽  
Myoepithelial Differentiation ◽  
Gland Type

Myoepithelial carcinoma, also called malignant myoepithelioma, is an extremely rare tumor of the salivary gland type. It is defined as a malignant neoplasm in which the tumor cells exhibit exclusively myoepithelial differentiation. Our case is a 48-year-old patient with no specific history who was presented to the hospital emergency room for respiratory difficulty and dysphagia progressively evolving for 08 weeks. A cervical CT was done which revealed a hypodense tumor process in T1 of 4 cm long axis obstructing the trachea well limited and richly vascularized. The diagnosis of tracheal myoepithelial carcinoma was made after histological and immunohistochemical analysis on a biopsy pending analysis of the operative specimen. Treatment remains initially surgical with appropriate postoperative radiotherapy and chemotherapy.

scholarly journals Clinical observations in three clinical cases with locally advanced chordomas. What is needed for early diagnosis with improved survival?

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Lena Marinova ◽  
◽  
Radoslav Georgiev ◽  
Nikolay Evgeniev ◽  
◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Postoperative Radiotherapy ◽  
Locally Advanced ◽  
Malignant Neoplasm ◽  
Immunohistochemical Analysis ◽  
Primary Diagnosis ◽  
High Tech ◽  
Surgical Interventions ◽  
Clinical Observations ◽  
Clinical Cases

Chordoma is a rare malignant neoplasm. It is usually diagnosed at an advanced stage, which contributes for the poor prognosis and high mortality. In this article, we will consider three clinical cases with locally advanced chordomas in order to emphasize the importance of early diagnosis by MRI and the need for strict pathohistological and immunohistochemical analysis. Our observations reported late diagnosis, slow tumor growth, and numerous partial tumor resections, enhancing the mitotic activity of chordoma tumor cells. After numerous operations, rapid local tumor progression with aggressive infiltration of adjacent healthy tissues was observed. Hematogenous dissemination is observed after the third year of primary diagnosis and repeated surgical interventions of locally advanced chordoma. The prognosis in locally advanced chordomas is extremely unfavorable. Early diagnosis requires MRI and biopsy with exact pathomorphological and immunohistochemical analysis. To improve the treatment results, early diagnosis and complex treatment, including radical surgery and assessment of the need for high-tech postoperative radiotherapy are required.

scholarly journals Hospital Emergency Room Savings via Health Line S24 in Portugal

Econometrics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 8
Author(s):  
Paula Simões ◽  
Sérgio Gomes ◽  
Isabel Natário
Keyword(s):  
National Health ◽  
Hospital Costs ◽  
Urgent Care ◽  
Hospital Emergency ◽  
Health Econometrics ◽  
Emergency Situations ◽  
Hospital Emergency Room ◽  
Major Factors ◽  
Hospital Emergency Departments ◽  
Weighted Values

Hospital emergency departments are often overused by patients that do not really need urgent care. These admissions are one of the major factors contributing to hospital costs, which should not be allowed to compromise the response and effectiveness of the National Health Services (SNS). The aim of this study is to perform a detailed spatial health econometrics analysis of the non-urgent emergency situations (classified by Manchester triage) by area, linking them with the efficient use of the national health line, the Saude24 line (S24 line). This is evaluated through the S24 savings calls, using a savings index and its spatial effectiveness in solving the non-urgent emergency situations. A savings call is a call by a user whose initial intention was to go to an urgency department, but who. after calling the S24 line. changed his/her mind. Given the spatial nature of the data, and resorting to INLA in a Bayesian paradigm, the number of non-urgent cases in the Portuguese urgency hospital departments is modeled in an autoregressive way. The spatial structure is accounted for by a set of random effects. The model additionally includes regular covariates and a spatially lagged covariate savings index, related with the S24 savings calls. Therefore, the response in a given area depends not only on the (weighted) values of the response in its neighborhood and of the considered covariates, but also on the (weighted) values of the covariate savings index measured in each neighbor, by means of a Bayesian Poisson spatial Durbin model.

Hospital emergency room simulation

1999 ◽  
Vol 31 (1) ◽  
pp. 92-94 ◽  
Author(s):  
Viera K. Proulx
Keyword(s):  
Emergency Room ◽  
Hospital Emergency ◽  
Hospital Emergency Room

Myoepithelial Carcinoma ex Pleomorphic Adenoma: Rare Case Report with Clinicopathologic and Immunohistochemical Features

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S86-S87
Author(s):  
M Khazaeli ◽  
Z Kamaluddin ◽  
M Taherian
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Nasal Passage ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Sublingual Gland ◽  
Myoepithelial Carcinoma ◽  
Minor Salivary Glands ◽  
Myoepithelial Differentiation ◽  
The Right

Abstract Introduction/Objective Myoepithelial carcinoma is identified by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. It occurs most commonly in the parotid gland followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Nasopharyngeal origin has been rarely reported. Methods/Case Report An afebrile 19-year-old female presented to the emergency department with persistent facial pressure, otalgia (right side greater than left side), rhinorrhea, and several episodes of epistaxis. One month before, she has been treated with Amoxicillin for three days with no relief, where Augmentin started for her for five days. About four days prior presentation, she was placed on Prednisone and Cefdinir. Over the next several days, she began having throat pain with difficulty swallowing. Routine blood work revealed a leukocytosis of 14.2 with normal differentiation. CT of the neck showed a large soft tissue mass centered at the right nasopharynx. Flexible nasal endoscopy performed bilaterally to reveal the nasopharynx is entirely obstructed with a lobulated mass filling the nasopharynx. On the right side, it extends into the posterior nasal passage filling the sphenoethmoid recess and the posterior floor of the nasal passage. Outpatient biopsy from nasopharynx mass is also performed. Results (if a Case Study enter NA) Mass biopsy reveals a mucinous and chondromyxoid background with mixed epithelial and myoepithelial differentiation. The is squamous metaplasia of myoepithelial cells and prominent mitotic activity and apoptotic activity. Immunohistochemistry was positive for CK5/6, calponin, BCL2, SMA, BerEp4, Sox10, and a proliferative index up to 40%. Based on this information Myoepithelial Carcinoma ex-pleomorphic adenoma of the nasopharynx is the diagnosis. Conclusion Carcinoma ex pleomorphic adenoma is usually a high-grade malignancy. It occurs most commonly in the parotid gland, followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Our case is one of the few cases of myoepithelial carcinoma arising in nasopharyngeal pleomorphic adenoma.

scholarly journals Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10

2007 ◽  
Author(s):  
Shigenori Nagata ◽  
Yoichi Ajioka ◽  
Ken Nishikura ◽  
Gen Watanabe ◽  
Takahiro Inoue ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Pyloric Gland ◽  
Gland Type

scholarly journals Metastatic Parotid Myoepithelial Carcinoma in a 7-Year-Old Boy

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Issam Saliba ◽  
Nazir El Khatib ◽  
Antoine Nehme ◽  
Selim Nasser ◽  
Nabil Moukarzel
Keyword(s):  
Parotid Gland ◽  
Facial Nerve ◽  
Smooth Muscle Actin ◽  
Postoperative Radiotherapy ◽  
Lumbar Vertebra ◽  
Myoepithelial Carcinoma ◽  
Cervical Lymph Nodes ◽  
Immunohistochemical Markers ◽  
First Case ◽  
Rare Malignancy

Myoepithelial carcinoma is a rare malignancy of the parotid gland that is usually seen in adults. We report the first case in children of myoepithelial carcinoma of the parotid gland with massive invasion of the facial nerve and metastasis to cervical lymph nodes. Due to its rarity, the treatment and the clinical course of this tumor are not well defined yet. We performed a total parotidectomy, a modified neck dissection, and a postoperative radiotherapy in 7-year-old boy. Sparing of the facial nerve was impossible; it was sacrificed and grafted with a sural nerve. Histopathology confirmed the diagnosis of a parotid gland carcinoma and immunohistochemical markers showed that the tumor cells express cytokeratin, epithelial membrane antigen, cytokeratin 7, smooth muscle actin, P63, CEA, and S100. This pattern of immunostaining is consistent with the diagnosis of myoepithelial carcinoma. On the postoperative tenth month he presented with a pulmonary and lumbar vertebra metastasis.

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