Preparation, Characterization and In-Vitro Release Study of Flurbiprofen Loaded Stealth Liposomes

This study seeks to formulate and evaluate a solid lipid nanoparticle-based, solidified micellar carrier system for oral delivery of cefepime. Cefepime has enjoyed a lot of therapeutic usage in the treatment of susceptible bacterial infections; however, its use is limited due to its administration as an injection only with poor patient compliance. Since oral drug administration encourage high patient compliance with resultant effect in improved therapy, cefepime was formulated as solid lipid microparticles for oral delivery using the concept of solidified micellar carrier system. The carrier system was evaluated based on particle yield, particle size and morphology, encapsulation efficiency (EE %), and thermal analysis using differential scanning calorimeter (DSC). Preliminary microbiological studies were done using gram positive and negative bacteria. In vitro release study was performed using biorelevant media, while in vivo release study was performed in white albino rats. The yield of solid lipid microparticles (SLM) ranged from 84.2 – 98.0 %. The SLM were spherical with size ranges of 3.8 ± 1.2 to 42.0 ± 1.4 µm. The EE % calculated ranged from 83.6 – 94.8 %. Thermal analysis showed that SLM was less crystalline with high potential for drug entrapment. Microbial studies showed that cefepime retained its broad spectrum anti-bacterial activity. In vitro release showed sustained release of cefepime from SLM, and in vivo release study showed high concentration of cefepime released in the plasma of study rats. The study showed that smart engineering of solidified micellar carrier system could be used to improve oral delivery of cefepime.

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Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.6.6 ◽

2018 ◽

Vol 11 (6) ◽

pp. 4331-4337

Author(s):

C Suja ◽

Sismy C

Keyword(s):

Sustained Release ◽

Guar Gum ◽

In Vitro Release ◽

Angle Of Repose ◽

Prolonged Release ◽

Weight Variation ◽

Sustained Release Tablets ◽

Release Study ◽

Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

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An in vitro release study of 5-fluoro-uracil (5-FU) from swellable poly-(2-hydroxyethyl methacrylate) (PHEMA) nanoparticles

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-008-3677-x ◽

2009 ◽

Vol 20 (5) ◽

pp. 1103-1114 ◽

Cited By ~ 29

Author(s):

Raje Chouhan ◽

A. K. Bajpai

Keyword(s):

In Vitro Release ◽

Hydroxyethyl Methacrylate ◽

Release Study ◽

Vitro Release

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Influence of different viscosity grade ethylcellulose polymers on encapsulation and in vitro release study of drug loaded nanoparticles

Journal of Pharmacy Research ◽

10.1016/j.jopr.2013.04.050 ◽

2013 ◽

Vol 7 (5) ◽

pp. 414-420 ◽

Cited By ~ 17

Author(s):

Amolkumar B. Lokhande ◽

Satyendra Mishra ◽

Ravindra D. Kulkarni ◽

Jitendra B. Naik

Keyword(s):

In Vitro Release ◽

Viscosity Grade ◽

Release Study ◽

Vitro Release

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In Vitro Release Study of Verapamil Hydrochloride Through Sodium Alginate Interpenetrating Monolithic Membranes

Drug Development and Industrial Pharmacy ◽

10.1081/ddc-100108373 ◽

2001 ◽

Vol 27 (10) ◽

pp. 1107-1114 ◽

Cited By ~ 14

Author(s):

Mahaveer D. Kurkuri ◽

Anandrao R. Kulkarni ◽

Mahadevappa Y. Kariduraganavar ◽

Tejraj M. Aminabhavi

Keyword(s):

Sodium Alginate ◽

In Vitro Release ◽

Verapamil Hydrochloride ◽

Release Study ◽

Vitro Release

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Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2019.16646 ◽

2019 ◽

Vol 19 (11) ◽

pp. 6899-6906 ◽

Cited By ~ 2

Author(s):

Salma E. Ahmed ◽

Hesham G. Moussa ◽

Ana M. Martins ◽

Yassmine Abbas ◽

Mohammad H. Al-Sayah ◽

...

Keyword(s):

In Vitro Release ◽

Pulsed Ultrasound ◽

Factors Affecting ◽

Stealth Liposomes ◽

Experimental Parameters ◽

Drug Doses ◽

Cancerous Cells ◽

Vitro Release ◽

Frequency Power

Typical methods used in cancer treatment, including chemotherapy, are debilitating because of the various adverse side effects experienced by cancer patients. The free drug injected into the patient at given doses affects both healthy and cancerous cells. Therefore, novel methods are being researched to ensure the selectivity of the treatment. The purpose of this study is to test the release of a model fluorescent drug, calcein, from echogenic stealth liposomes, triggered by lowfrequency pulsed ultrasound. Several experimental parameters related to the ultrasound (US) and the investigated liposomes were varied in order to examine their effect on the acoustic release. Upon analysis of experimental results, the study concluded that release can be maximized by optimizing the sonication frequency, power density, and US pulse duration. When a non-isothermal chamber is used to conduct the experiments, it is important to have longer ‘Off’ than ‘On’ US periods in order to avoid overheating the liposomes. Applying such pulsation pattern can also be utilized to achieve slower release rates, which safely meet the desired drug levels at the end of the session. Our study also concluded that optimizing the liposome concentration is vital to delivering desired drug doses. Additionally, the type of lipids used in the synthesis should be carefully selected to produce stable yet acoustically sensitive liposomes capable of releasing at desired rates.

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Physicochemical properties and in-vitro release study of CFLE-chitosan microsphere beads

Journal of Polymer Research ◽

10.1007/s10965-019-1954-7 ◽

2019 ◽

Vol 26 (12) ◽

Cited By ~ 1

Author(s):

Vandana Suryavanshi ◽

Preeti K. Suresh ◽

Chayan Das ◽

Tungabidya Maharana

Keyword(s):

Physicochemical Properties ◽

In Vitro Release ◽

Chitosan Microsphere ◽

Release Study ◽

Vitro Release

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Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

10.1063/5.0007923 ◽

2020 ◽

Author(s):

R. Rozana ◽

Y. Yulizar ◽

A. Saefumillah ◽

D. O. B. Apriandanu

Keyword(s):

In Vitro Release ◽

Chitosan Nanoparticle ◽

Release Study ◽

Vitro Release

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Characterisation, in vitro release study, and antibacterial activity of montmorillonite-gentamicin complex material

Materials Science and Engineering C ◽

10.1016/j.msec.2016.09.031 ◽

2017 ◽

Vol 70 ◽

pp. 471-478 ◽

Cited By ~ 26

Author(s):

A. Rapacz-Kmita ◽

M.M. Bućko ◽

E. Stodolak-Zych ◽

M. Mikołajczyk ◽

P. Dudek ◽

...

Keyword(s):

Antibacterial Activity ◽

In Vitro Release ◽

Complex Material ◽

Release Study ◽

Vitro Release

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Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

ISRN Pharmaceutics ◽

10.1155/2013/983053 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Elham Khodaverdi ◽

Fatemeh Kheirandish ◽

Farnaz Sadat Mirzazadeh Tekie ◽

Bibi Zahra Khashyarmanesh ◽

Farzin Hadizadeh ◽

...

Keyword(s):

Phase Transition ◽

Transition Temperature ◽

Phase Transition Temperature ◽

Delivery System ◽

In Vitro Release ◽

In Situ Forming ◽

Release Study ◽

Vitro Release

In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration.

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