scholarly journals Metabolic impact of weight variations in Icelandic horses

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10764
Author(s):  
Julien Delarocque ◽  
Florian Frers ◽  
Korinna Huber ◽  
Klaus Jung ◽  
Karsten Feige ◽  
...  
Keyword(s):  
Weight Gain ◽  
Linear Models ◽  
Metabolic Response ◽  
Insulin Response ◽  
Oral Glucose ◽  
Insulin Dysregulation ◽  
One Year ◽  
Rotation Set ◽  
The Relationship ◽  
Icelandic Horses

Background Insulin dysregulation (ID) is an equine endocrine disorder, which is often accompanied by obesity and various metabolic perturbations. The relationship between weight variations and fluctuations of the insulin response to oral glucose tests (OGT) as well as the metabolic impact of ID have been described previously. The present study seeks to characterize the concomitant metabolic impact of variations in the insulin response and bodyweight during repeated OGTs using a metabolomics approach. Methods Nineteen Icelandic horses were subjected to five OGTs over one year and their bodyweight, insulin and metabolic response were monitored. Analysis of metabolite concentrations depending on time (during the OGT), relative bodyweight (rWeight; defined as the bodyweight at one OGT divided by the mean bodyweight across all OGTs) and relative insulin response (rAUCins; defined accordingly from the area under the insulin curve during OGT) was performed using linear models. Additionally, the pathways significantly associated with time, rWeight and rAUCins were identified by rotation set testing. Results The results suggested that weight gain and worsening of ID activate distinct metabolic pathways. The metabolic profile associated with weight gain indicated an increased activation of arginase, while the pathways associated with time and rAUCins were consistent with the expected effect of glucose and insulin, respectively. Overall, more metabolites were significantly associated with rWeight than with rAUCins.

scholarly journals The Relationship Between Gestational Weight Gain, Pre-pregnancy BMI, and Prenatal Diet Quality (P18-039-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Haley Parker ◽  
Karen McCurdy ◽  
Alison Tovar ◽  
Maya Vadiveloo
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Diet Quality ◽  
Linear Models ◽  
Maternal Diet ◽  
Normal Weight ◽  
Sensitivity Analyses ◽  
Gestational Weight ◽  
Funding Sources ◽  
The Relationship

Abstract Objectives Gestational weight gain (GWG) may reflect dynamic changes to prenatal diet quality, however, this relationship has been understudied. This study explored the relationship between GWG, pre-pregnancy BMI, and prenatal diet quality. Methods A secondary analysis examined a subset of 1268 women in the longitudinal Infant Feeding Practices Study (IFPS II) with 3rd trimester Diet History Questionnaire data. Diet quality was assessed with the Alternative Health Eating Index for Pregnancy (AHEI-P). Self-reported pre-pregnancy BMI, and total GWG (72% response rate) were used to classify GWG as inadequate (I), adequate (A), and excessive (E) according to the Institute of Medicine's recommendations. Tukey-adjusted generalized linear models, adjusting for sociodemographic factors, Women, Infants, and Children participation, parity, and energy intake, compared GWG groups on mean AHEI-P scores. The interaction between pre-pregnancy BMI and GWG group was tested and if significant, models were stratified by BMI group. Sensitivity analyses using multiply imputed GWG data were conducted. Results On average, AHEI-P scores were 61.3 (of 130), women were 28.9 years, higher socioeconomic status (40% college graduates) and mostly non-Hispanic White (84%). Pre-pregnancy BMI and GWG were inversely associated with AHEI-P scores (P < 0.0001). The association between GWG and diet quality was modified by BMI group (P = 0.04). In stratified adjusted analyses, GWG was associated with AHEI-P scores (P < 0.05) among women with pre-pregnancy underweight (I = 54.4 ± 3.9, A = 59.7 ± 3.6, E = 63.5 ± 3.5), normal weight (I = 59.2 ± 1.5, A = 61.0 ± 1.2, E = 59.3 ± 1.2), overweight (I = 62.3 ± 2.9, A = 60.7 ± 1.6, E = 59.4 ± 1.5), and obesity (I = 59.2 ± 1.8, A = 57.8 ± 2.0, E = 60.6 ± 1.5). However, no significant post-hoc differences between GWG groups were observed among any of the pre-pregnancy BMI groups. Findings from the multiple imputation analysis did not differ from complete case analysis findings. Conclusions GWG and prenatal diet quality differed according to pre-pregnancy BMI in this study. Adherence to GWG recommendations during pregnancy is an important predictor of maternal diet quality and should be examined in conjunction with pre-pregnancy BMI. Funding Sources There are no funding sources to disclose.

scholarly journals Relationship between plasma cortisol level and bodyweight and antler size in farmed fallow deer

2021 ◽  
Vol 51 (3) ◽  
pp. 355-361
Author(s):  
K. Dziki-Michalska ◽  
K. Tajchman ◽  
S. Kowalik ◽  
M. Bogdaszewski
Keyword(s):  
Weight Gain ◽  
Cortisol Level ◽  
Plasma Cortisol ◽  
Age Groups ◽  
Fallow Deer ◽  
Plasma Cortisol Level ◽  
Antler Growth ◽  
Antler Size ◽  
One Year ◽  
The Relationship

The aim of this study was to demonstrate the relationship between the plasma cortisol level and bodyweight and antler size in farmed male fallow deer (Dama dama) of various ages. The study involved 33 animals divided into three age groups: one year old, three years old, and older. Their bodyweight was measured and blood samples were taken twice a year during antler growth (May) and before the rut (September). Whole antlers were collected in September to measure their length and weight. The plasma cortisol concentration was determined with an immunoenzymatic method. The correlations between cortisol level and bodyweight were significant and positive in both May and September (P ≤0.05). There was a negative correlation between weight gain and change in cortisol levels (P ≤0.05). Thus, fallow deer with large seasonal changes in cortisol gained less weight from May to September. The results of the present study indicated that calmer animals with lower cortisol fluctuations should be selected for breeding, which would contribute to greater stability of weight gain.

scholarly journals Weight loss is linearly associated with a reduction of the insulin response to an oral glucose test in Icelandic horses

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Julien Delarocque ◽  
Florian Frers ◽  
Korinna Huber ◽  
Karsten Feige ◽  
Tobias Warnken
Keyword(s):  
Weight Loss ◽  
Insulin Response ◽  
Oral Glucose ◽  
Glucose Test ◽  
Oral Glucose Test ◽  
Icelandic Horses

scholarly journals Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study

2021 ◽  
Vol 5 ◽  
pp. 248
Author(s):  
James M. Njunge ◽  
Gerard Bryan Gonzales ◽  
Moses M. Ngari ◽  
Johnstone Thitiri ◽  
Robert H.J. Bandsma ◽  
...  
Keyword(s):  
Weight Gain ◽  
Hospital Discharge ◽  
Systemic Inflammation ◽  
Acute Illness ◽  
Severe Malnutrition ◽  
Post Discharge ◽  
Soluble Cd14 ◽  
Negatively Associated ◽  
One Year ◽  
The Relationship

Background: Rapid growth should occur among children with severe malnutrition (SM) with medical and nutritional management. Systemic inflammation (SI) is associated with death among children with SM and is negatively associated with linear growth. However, the relationship between SI and weight gain during therapeutic feeding following acute illness is unknown. We hypothesised that growth post-hospital discharge is associated with SI among children with SM. Methods: We conducted secondary analysis of data from HIV-uninfected children with SM (n=98) who survived and were not readmitted to hospital during one year of follow-up. We examined the relationship between changes in absolute deficits in weight and mid-upper-arm circumference (MUAC) from enrolment at stabilisation to 60 days and one year later, and untargeted plasma proteome, targeted cytokines/chemokines, leptin, and soluble CD14 using multivariate regularized linear regression. Results: The mean change in absolute deficit in weight and MUAC was -0.50kg (standard deviation; SD±0.69) and -1.20cm (SD±0.89), respectively, from enrolment to 60 days later. During the same period, mean weight and MUAC gain was 3.3g/kg/day (SD±2.4) and 0.22mm/day (SD±0.2), respectively. Enrolment interleukins; IL17-alpha and IL-2, and serum amyloid P were negatively associated with weight and MUAC gain during 60 days. Lipopolysaccharide binding protein and complement component 2 were negatively associated with weight gain only. Leptin was positively associated with weight gain. Soluble CD14, beta-2 microglobulin, and macrophage inflammatory protein 1 beta were negatively associated with MUAC gain only. Glutathione peroxidase 3 was positively associated with weight and MUAC gain during one year. Conclusions: Early post-hospital discharge weight and MUAC gain were rapid and comparable to children with uncomplicated SM treated in the community. Higher concentrations of SI markers were associated with less weight and MUAC gain, suggesting inflammation negatively impacts recovery from wasting. This finding warrants further research on reducing inflammation on growth among children with SM.

scholarly journals Sex Differences in the Effects of Inhaled Corticosteroids on Weight Gain among Patients with Asthma

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Amanda K. Rizk ◽  
Kim L. Lavoie ◽  
Véronique Pepin ◽  
Alicia Wright ◽  
Simon L. Bacon
Keyword(s):  
Weight Gain ◽  
Weight Change ◽  
Linear Models ◽  
Inhaled Corticosteroids ◽  
Asthmatic Patients ◽  
Oral Corticosteroids ◽  
Baseline Weight ◽  
Underlying Mechanisms ◽  
One Year ◽  
Main Effects

Background. Studies have shown that asthma and asthma exacerbations are related to body weight and that this relationship might be sex-specific. While oral corticosteroids have been associated with weight gain, little is known about the effect of inhaled corticosteroid (ICS) use on short-term weight gain. The purpose of the present study was to examine whether ICSs would be associated with weight gain among asthmatic patients. Methods. A total of 180 adult patients with physician-diagnosed asthma provided details of their medical history and demographic information, along with height and weight at baseline and at one year. Weight change was defined as follow-up minus baseline weight. General linear models were used to assess the relationship between ICS dose (fluticasone propionate equivalent) and sex. Results. Significant main effects of sex (P=.005) and ICS dose (P=.036) and an interaction effect of sex and ICS dose (P=.003) on weight change were observed. Further analysis of the interaction indicated that women had greater weight gain, while men had decreased weight with increased ICS dose. Conclusions. Findings suggest that ICSs may trigger weight gain in females and highlight the need for studies to confirm this relationship and examine the potential underlying mechanisms.

Relationship between insulin response to oral glucose load and creatinine clearance

Diabetes ◽  
1975 ◽  
Vol 24 (12) ◽  
pp. 1066-1071 ◽  
Author(s):  
K. Yasuda ◽  
T. Sato ◽  
T. Furuyama ◽  
K. Yashinaga
Keyword(s):  
Creatinine Clearance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load
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