Impaired wound healing in patients with diabetes

2001 ◽  
Vol 15 (38) ◽  
pp. 39-45 ◽  
Author(s):  
Laila King
Keyword(s):  
Wound Healing ◽  
Impaired Wound Healing ◽  
Patients With Diabetes

scholarly journals The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

2020 ◽  
Vol 13 (4) ◽  
pp. 60 ◽  
Author(s):  
Simona Federica Spampinato ◽  
Grazia Ilaria Caruso ◽  
Rocco De Pasquale ◽  
Maria Angela Sortino ◽  
Sara Merlo
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Negative Consequences ◽  
Impaired Wound Healing ◽  
Patients With Diabetes ◽  
Reparative Process ◽  
Dipeptidylpeptidase 4 ◽  
Therapeutic Alternatives ◽  
Near Future ◽  
Old Drugs

Chronic wounds often occur in patients with diabetes mellitus due to the impairment of wound healing. This has negative consequences for both the patient and the medical system and considering the growing prevalence of diabetes, it will be a significant medical, social, and economic burden in the near future. Hence, the need for therapeutic alternatives to the current available treatments that, although various, do not guarantee a rapid and definite reparative process, appears necessary. We here analyzed current treatments for wound healing, but mainly focused the attention on few classes of drugs that are already in the market with different indications, but that have shown in preclinical and few clinical trials the potentiality to be used in the treatment of impaired wound healing. In particular, repurposing of the antiglycemic agents dipeptidylpeptidase 4 (DPP4) inhibitors and metformin, but also, statins and phenyotin have been analyzed. All show encouraging results in the treatment of chronic wounds, but additional, well designed studies are needed to allow these drugs access to the clinics in the therapy of impaired wound healing.

scholarly journals Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Wenlong Shang ◽  
Guilin Chen ◽  
Yinxiu Li ◽  
Yujuan Zhuo ◽  
Yuhong Wang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Wound Healing ◽  
Static Magnetic Field ◽  
Macrophage Polarization ◽  
Healing Process ◽  
Critical Role ◽  
Resolution Of Inflammation ◽  
Impaired Wound Healing ◽  
Patients With Diabetes ◽  
Magnetic Therapy

Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although magnetic therapy is known to improve microcirculation, its effect on wound healing remains uncertain. In the present study, we found that 0.6 T static magnetic field (SMF) significantly accelerated wound closure and elevated reepithelialization and revascularization in diabetic mice. Notably, SMF promoted the wound healing by skewing the macrophage polarization towards M2 phenotype, thus facilitating the resolution of inflammation. In addition, SMF upregulated anti-inflammatory gene expression via activating STAT6 and suppressing STAT1 in macrophage. Taken together, our results indicate that SMF may be a promising adjuvant therapeutic tool for treating diabetic wounds.

scholarly journals Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Elena Tsourdi ◽  
Andreas Barthel ◽  
Hannes Rietzsch ◽  
Andreas Reichel ◽  
Stefan R. Bornstein
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Standard Treatment ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Severe Problem ◽  
Impaired Wound Healing ◽  
Patients With Diabetes ◽  
Extensive Debridement

Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care.

scholarly journals Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1445
Author(s):  
Pei-Fang Hsieh ◽  
Cheng-Chia Yu ◽  
Pei-Ming Chu ◽  
Pei-Ling Hsieh
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
High Glucose ◽  
Inhibitory Effect ◽  
Diabetic Patients ◽  
Impaired Wound Healing ◽  
Stress Indicator ◽  
Patients With Diabetes ◽  
Nfκb Pathway ◽  
Oral Wound Healing

Impaired wound healing often occurs in patients with diabetes and causes great inconvenience to them. Aside from the presence of prolonged inflammation, the accumulation of oxidative stress is also implicated in the delayed wound healing. In the present study, we tested the effect of verbascoside, a caffeoyl phenylethanoid glycoside, on the improvement of cell viability and wound healing capacity of gingival epithelial cells under high glucose condition. We showed that verbascoside attenuated the high glucose-induced cytotoxicity and impaired healing, which may be associated with the downregulation of oxidative stress. Our results demonstrated that verbascoside increased the activity of the antioxidant enzyme SOD and reduced the oxidative stress indicator, 8-OHdG, as well as apoptosis. Moreover, verbascoside upregulated the PGC1-α and NRF1 expression and promoted mitochondrial biogenesis, which was mediated by suppression of PKC/HMGB1/RAGE/NFκB signaling. Likewise, we showed the inhibitory effect of verbascoside on oxidative stress was via repression of PKC/HMGB1/RAGE/NFκB activation. Also, our data suggested that the PKC-mediated oxidative stress may lead to the elevated production of inflammatory cytokines, IL-6 and IL-1β. Collectively, we demonstrated that verbascoside may be beneficial to ameliorate impaired oral wound healing for diabetic patients.

scholarly journals Comparative analysis of the effectiveness of the oral mucosa traumatic lesion treatment in patients with a comorbidity

2021 ◽  
Vol 26 (3) ◽  
pp. 229-233
Author(s):  
Yu. A. Makedonova ◽  
S. V. Poroyskiy ◽  
L. M. Gavrikova ◽  
О. Yu. Afanaseva ◽  
S. V. Dyachenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Comparative Analysis ◽  
Oral Mucosa ◽  
Healing Process ◽  
Treatment Protocol ◽  
Wound Healing Process ◽  
Impaired Wound Healing ◽  
Traumatic Lesion ◽  
Patients With Diabetes

Relevance. Patients with diabetes are prone to complications which negatively affect their quality of life. In such patients, several comorbidities may develop. One of the complications of diabetes mellitus is an impaired wound healing. Oral wound healing associated with the constant chronic trauma by sharp edges of teeth and prostheses is not an exception. Such wounds are characterized by a long, persistent, sluggish process of restoring the integrity of the oral mucosa epithelium.Materials and methods. In this paper, a comparative analysis of the effectiveness of wound treatment was carried out in 52 patients with diabetes mellitus. All patients were randomized into two equal groups. In the first group of patients, wounds were treated with traditional methods of pharmacotherapy, while in the second group, the oral mucosa was exposed to ozone and ozonated oil was applied. The patients were monitored and followed up for 14 days and as the reparative function was restored. The area and depth of the wound, the nature and amount of exudate, destruction, the edges of the wound and the surrounding connective tissue were taken into account.Results. The positive wound healing process was noted in both groups during the follow-up period. However, the inclusion of the ozone therapy in the treatment protocol favored faster restoration of the epithelium integrity.Conclusion. The present data will help dentists monitor and treat the wound process, which in turn will prevent malignancy as well as improve the prognosis for patients with diabetes.

The role of angiopoetic factors in wound healing among patients with diabetes treated with negative-pressure wound therapy

Leczenie Ran ◽  
2015 ◽  
Vol 11 (4) ◽  
pp. 171-178
Author(s):  
Beata Mrozikiewicz-Rakowska ◽  
Joanna Kania ◽  
Ewelina Bucior ◽  
Adriana Nowak ◽  
Tomasz Grzela ◽  
...  
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Wound Therapy ◽  
Patients With Diabetes

Short Report: The Moisture Balance with Aloe Vera Gel in Diabetic Wound Healing

2018 ◽  
Vol 1 (1) ◽  
pp. 21-23
Author(s):  
Fahrianto Selamet ◽  
Andi Mayasari Usman ◽  
Rian Adi Pamungkas
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Wound Care ◽  
Aloe Vera ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Short Report ◽  
Bacterial Reduction ◽  
Moisture Balance ◽  
Patients With Diabetes

Diabetic foot ulcer (DF) is a chronic complication of diabetes mellitus (DM), which impact on the morbidity, mortality and quality of patients’ lives.Of those patients with diabetes mellitus, approximately 15% to 25% developed to the foot ulcer. Beside has the infection and debridement of devitalized tissue downloading; the moisture imbalance becomes the factors of recalcitrant to healing. Moist wound healing is often contraindicated to the non-healable wounds. While wound care involves the debridement, bacterial reduction, and moisture balance in order to achieve the good granulation of the tissue development and adequate blood supply.

Sign in / Sign up

Export Citation Format

Share Document