Malignant Degeneration to Leiomyosarcoma of the Anorectal Junction Invading the Prostate

We tested the hypothesis that proton magnetic resonance spectroscopic imaging (1H-MRSI) can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing as a result of either low-to-high grade malignant transformation or of post-therapeutic recurrence. Twenty-seven patients with histologically verified cerebral gliomas were studied repeatedly with 1H-MRSI over a period of 3.5 years. At the time of each 1H-MRSI study, clinical examination, MRI, positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG), and biopsy findings (when available) were used to categorize each patient as being either «stable» or «progressive». Measures of the between-studies percent changes in the choline 1H-MRSI signal intensity, obtained without knowledge of the clinical categorization, segregated the groups with a high degree of statistical significance. All progressive cases showed a between-studies choline signal increase of more than 45%, while all stable cases showed an elevation of less than 35%, no change, or even a decreased signal. We conclude that increased choline coincides with malignant degeneration of cerebral gliomas, and therefore, may possibly be used as a supportive indicator of malignant degeneration of these neoplasms.

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Porokeratosis with an Invasive Squamous Cell Carcinoma: A Case Report and Review of Literature

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v32i1.21035 ◽

2014 ◽

Vol 32 (1) ◽

pp. 31-36

Author(s):

M Nessa ◽

L Khondker ◽

MA Bari ◽

MSI Khan ◽

M Rahman ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Granular Layer ◽

Malignant Degeneration ◽

Invasive Squamous Cell Carcinoma ◽

Review Of Literature ◽

Large Plaque ◽

Cornoid Lamella ◽

Multiple Nodules

Porokeratosis is a clonal disorder of epidermal keratinization, which is characterized by hyperkeratotic papules or plaques that are surrounded by a thread-like elevated border. The histopathologic hallmark of porokeratosis is the cornoid lamella, which is a thin column of parakeratosis that overlies a thin or absent granular layer and that corresponds to the raised, hyperkeratotic border. Porokeratosis has five clinical types and malignant degeneration has been described in all forms of porokeratosis. We report a forty five year old farmer with a large plaque in chest for 30 years and multiple nodules within the large plaque for 2 years. A section of skin from margin of the plaque reveals histopathological features of porokeratosis and section from nodules reveals an invasive squamous cell carcinoma. To the best of our knowledge, this is the first reported case of porokeratosis transformed to squamous cell carcinoma on Bangladesh. DOI: http://dx.doi.org/10.3329/jbcps.v32i1.21035 J Bangladesh Coll Phys Surg 2014; 32: 31-36

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SEBACEOUS MALIGNANT DEGENERATION.

The Lancet ◽

10.1016/s0140-6736(02)67816-x ◽

1858 ◽

Vol 71 (1807) ◽

pp. 388

Keyword(s):

Malignant Degeneration

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Giant Cell Tumor of Bone, current treatments, and potential therapeutic alternatives

American Journal of Cancer Research and Reviews ◽

10.28933/ajocrr-2020-10-0205 ◽

2020 ◽

pp. 13

Author(s):

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Research Work ◽

Cell Tumor ◽

Treatment Modalities ◽

Malignant Degeneration ◽

Primary Malignancy ◽

Primary Bone Tumor ◽

Advantages And Disadvantages ◽

Therapeutic Alternatives

Giant cell tumor of bone (GCTB) is a primary bone tumor, locally aggressive. For many, a GCTB is considered a tumor with an unpredictable behavior, particularly regarding recurrences, pulmonary implants, and the possibility of primary malignancy. In terms of risk of recurrence, it is known that it is associated with the type of treatment used initially for the GCTB. The greater the number or recurrences, the greater the risk of pulmonary implants, and the greater the risk of malignant degeneration. Therefore, much of the prognosis of this tumor could be related to the type of initial treatment. Hence the importance of the treatment theme. This review includes a comparison between the various modalities for treatment in GCTB, considering the advantages and disadvantages of each one. Existing GCTB treatments are not 100% safe and effective at the same time. and this is the reason why the search for other treatment modalities should continue to offer a better oncologic and functional outcome to patients. In the end of this review, based on research work, we also mention other possible therapeutic options that could be explored and used in the future for GCT treatment.

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Cystic cervical metastasis: A diagnostic dilemma

IP Journal of Otorhinolaryngology and Allied Science ◽

10.18231/j.ijoas.2021.015 ◽

2021 ◽

Vol 4 (2) ◽

pp. 75-78

Author(s):

Manish Gupta ◽

Anshul Singh ◽

Cynthia Kaur ◽

Akanksha Gupta

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Benign Lesion ◽

Tongue Base ◽

Malignant Degeneration ◽

Neck Swelling ◽

Cervical Metastasis ◽

Diagnostic Dilemma ◽

Branchial Cleft

Metastasis of head neck squamous cell carcinoma to regional deep cervical nodes is a common and usually are bony hard, solid. But sometimes they may present as a cystic mass which makes it a diagnostic challenge, in absence of evident primary, for the treating doctor. Previously they have been labeled as cancers of branchial cleft cysts which have undergone malignant degeneration. With the advancement in understanding of tumor pathophysiology most researchers now have concluded that these are tumors from tissue of waldeyer’s ring which have the potential of producing cystic cervical metastasis. : A 57-year-old male presented to our department with a right side slow growing neck swelling for 2 years. The rest of ear, nose, throat examination was normal. The fine needle aspiration cytology revealed clear fluid. The diagnosis of branchial cleft cyst was made and patient counselled for surgery for benign lesion. After a period of one month the patient presented with change in voice, difficulty in swallowing and another swelling on left side of the neck. FNAC from the left side swelling revealed metastatic squamous cell carcinoma and PET-CT revealed a tongue base growth. Patient underwent an excision of growth from tongue base and neck dissection on both sides. Even for cystic neck swelling in an adult over 40 years of age, the possibility of malignancy should be kept, until proven otherwise.

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