Colorectal adenomas and malignant degeneration: Post-polipectomy follow up

1995 ◽  
Vol 108 (4) ◽  
pp. A514
Author(s):  
F. Negrini ◽  
U. Bonassi ◽  
F. Svanoni ◽  
A. Malesci ◽  
R. Colombi ◽  
...  
Keyword(s):  
Colorectal Adenomas ◽  
Malignant Degeneration

Colorectal adenomas on follow-up colonoscopy: is the cancer risk unchanged?

The Lancet ◽  
1995 ◽  
Vol 345 (8958) ◽  
pp. 1126-1127 ◽  
Author(s):  
MichaelO. Blackstone
Keyword(s):  
Cancer Risk ◽  
Colorectal Adenomas

scholarly journals Cognitive Functions in Repeated Glioma Surgery

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1077
Author(s):  
Gabriele Capo ◽  
Miran Skrap ◽  
Ilaria Guarracino ◽  
Miriam Isola ◽  
Claudio Battistella ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Inferior Frontal Gyrus ◽  
Insular Cortex ◽  
Malignant Degeneration ◽  
Low Grade ◽  
Normal Range ◽  
Glioma Surgery ◽  
Number Of Patients ◽  
Significant Difference

Low-grade gliomas (LGG) are slow-growing brain tumors infiltrating the central nervous system which tend to recur, often with malignant degeneration after primary treatment. Re-operations are not always recommended due to an assumed higher risk of neurological and cognitive deficits. However, this assumption is relatively ungrounded due to a lack of extensive neuropsychological testing. We retrospectively examined a series of 40 patients with recurrent glioma in eloquent areas of the left hemisphere, who all completed comprehensive pre- (T3) and post-surgical (T4) neuropsychological assessments after a second surgery (4-month follow up). The lesions were most frequent in the left insular cortex and the inferior frontal gyrus. Among this series, in 17 patients the cognitive outcomes were compared before the first surgery (T1), 4 months after the first surgery (T2), and at T3 and T4. There was no significant difference either in the number of patients scoring within the normal range between T3 and T4, or in their level of performance. Further addressing the T1–T4 evolution, there was no significant difference in the number of patients scoring within the normal range. As to their level of performance, the only significant change was in phonological fluency. This longitudinal follow-up study showed that repeated glioma surgery is possible without major damage to cognitive functions in the short-term period (4 months) after surgery.

Impact of colonoscopy screening on individuals at high risk of hereditary nonpolyposis colorectal cancer (HNPCC).

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 384-384
Author(s):  
C. Guillen-Ponce ◽  
C. Martinez-Sevila ◽  
R. Jover ◽  
R. Perea ◽  
M. Molina-Garrido ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Early Stage ◽  
Colorectal Adenomas ◽  
Medical Documentation ◽  
Synchronous Tumors ◽  
Colonoscopy Screening ◽  
Amsterdam Criteria ◽  
The Impact

384 Background: Colonoscopy screening reduces the incidence of, and mortality from, colorectal cancer (CRC) in individuals with HNPCC. The aim of this study was to determine the impact of colonoscopic follow-up in individuals at high risk of HNPCC, in terms of detection of precursor lesions (adenomas) or cancer. Methods: Between 2005-2008, 163 individuals with HNPCC were advised to undergo regular follow-up colonoscopy. Compliance and results of the scans were evaluated annually and were verified with medical documentation. Results: Of the 125 individuals who underwent at least one colonoscopy during the follow-up period of colonoscopy screening, in 33 subjects (26%) at least one colonic adenoma was detected. The median number of adenomas detected per colonoscopy in individuals with polyps was 2. The number of colonoscopies with polyps did not differ between women and men. However, the number of polyps removed by colonoscopy and the total number of polyps removed during the follow-up period was significantly higher in men (p = 0.005, p = 0.05 bilateral, respectively). 5 individuals (4%) were diagnosed with CRC, one of whom had two synchronous tumors. Of these, four individuals had properly followed the screening recommendations with the recommended frequency. In the case where two synchronous tumors were detected, it was the first colonoscopy screening that had been performed on the individual. None had had cancer previously, they were healthy relatives of an index case. All except one belonged to families that fulfilled the Amsterdam criteria I / II. All the tumors were diagnosed at an early stage, except two, which exhibited positive nodes. Conclusions: Colonoscopy screening is effective in diagnosing colorectal adenomas and cancer in individuals with HNPCC. Men with HNPCC have a greater number of colorectal adenomas. Screening allows the detection of colorectal cancer at an early stages. Funded by a young researcher's grant from the Spanish Society of Medical Oncology 2006. No significant financial relationships to disclose.

Risk factors of colorectal adenoma recurrence among individuals under 50 years of age compared to those 50 years of age or older.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1554-1554
Author(s):  
Christine Louise Sardo Molmenti ◽  
Jingyan Yang ◽  
Cynthia A Thomson ◽  
Elizabeth A Hibler ◽  
Gloria Ho ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colorectal Adenoma ◽  
Colorectal Adenomas ◽  
Age Group ◽  
Current Smoking ◽  
Adenoma Recurrence ◽  
Younger Age ◽  
History Of ◽  
Colorectal Adenoma Recurrence

1554 Background: Colorectal cancer incidence and mortality are increasing among individuals < 50 years of age. Data are limited regarding the epidemiology of colorectal adenomas in this younger age group. This study investigated and compared risk factors associated with recurrence of adenomas in individuals under and over 50 years of age. Methods: Pooled analyses from the Wheat Bran Fiber and Ursodeoxycholic Acid phase III, randomized, controlled clinical trials included 1,623 participants, aged 40-80 years. Each completed baseline questionnaires related to family history and lifestyle habits, had one or more colorectal adenomas removed at baseline, and had a follow-up colonoscopy during the trial (mean follow up 36 months). Univariate and multivariate logistic regression modeling estimated the association between age and colorectal adenoma recurrence, and evaluate multiple risk factors, while controlling for confounding factors. Results: A statistically significant increased trend was found for colorectal adenoma recurrence with increasing age ( Ptrend= < 0.001). Multivariate logistic regression revealed that risk factors significantly associated with adenoma recurrence in the ≥50 age group (n = 1,523) included history of previous polyps, characteristics of adenomas removed at baseline (multiple adenomas and villous feature), current smoking, and an increased waist circumference. Although risk profile in the < 50 age group (n = 95) shared similarities with that in the ≥50 age group (e.g., current smoking), there were a few notable differences: history of previous polyps was a more prominent predictor for recurrence for the < 50 (OR< 50 = 4.76 and OR≥50 = 1.33, Pinteraction = 0.042), whereas baseline characteristics of adenomas were more important for the ≥50 (multiple adenomas: OR< 50 = 0.40 and OR≥50 = 2.28, Pinteraction = 0.043). Conclusions: Predisposition to colorectal adenoma is a more important risk factor for recurrence in the < 50 as compared to the ≥50. Future studies need to identify susceptibility factors contributing to the increasing incidence of colorectal cancer in this younger age group.

Argon Plasma Coagulation after Piecemeal Polypectomy of Sessile Colorectal Adenomas: Long-Term Follow-Up Study

Endoscopy ◽  
2003 ◽  
Vol 35 (3) ◽  
pp. 212-218 ◽  
Author(s):  
J. Regula ◽  
E. Wronska ◽  
M. Polkowski ◽  
A. Nasierowska-Guttmejer ◽  
J. Pachlewski ◽  
...  
Keyword(s):  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Colorectal Adenomas ◽  
Plasma Coagulation ◽  
Follow Up Study ◽  
Long Term Follow Up

scholarly journals Endoscopic mucosal resection of flat and sessile colorectal adenomas: Our experience with long-term follow-ups

2014 ◽  
Vol 71 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Sasa Grgov ◽  
Predrag Dugalic ◽  
Ratko Tomasevic ◽  
Tomislav Tasic
Keyword(s):  
Endoscopic Mucosal Resection ◽  
Complete Removal ◽  
Colorectal Adenomas ◽  
Invasive Technique ◽  
En Bloc ◽  
Carcinoma Of The Colon ◽  
Mucosal Resection ◽  
Piecemeal Resection

Bacground/Aim. Endoscopic mucosal resection (EMR) or mucosectomy is a removing method of flat or sessile lesions, laterally spreading tumors and carcinoma of the colon or the rectum limited to mucosa or the surface part of the submucosa. The aim of the study was to estimate the efficacy and safety of EMR in removing flat and sessile colorectal adenomas. Methods. This prospective study involved 140 patients during the period of 8 years. A total of 187 colorectal adenomas were removed using the EMR method ?inject and cut with snare?. Results. The approximate size of mucosectomised adenomas was 13.6 mm (from 8 mm to 60 mm). There was a total of 48 (25.7%) flat adenomas and 139 (74.3%) sessile adenomas, (p < 0.01). Using ?en bloc? and ?piecemeal? resection, 173 (92.5%) and 14 (7.5%) of colorectal adenomas were removed, respectively. In all the cases, a complete removal of colorectal adenomas was achieved. Two (1.4%) patients had adenoma removal with intramucosal carcinoma each. In the average follow-up period of 21.2 ? 17.8 months, 2 (1.4%) patients had adenoma relapse after EMR. Considering complications, there was bleeding in 1 (0.7%) patient with a big rectum adenoma removed with EMR. Furthermore, one (0.7%) patient had a postcoagulation syndrome after cecal adenoma was removed by EMR. Conclusion. EMR is an efficient, safe and minimally invasive technique of removing flat and sessile adenomas in the colon and the rectum, with a very low percentage of adenoma recurrence over a long period of monitoring.

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