scholarly journals Cystic cervical metastasis: A diagnostic dilemma

2021 ◽  
Vol 4 (2) ◽  
pp. 75-78
Author(s):  
Manish Gupta ◽  
Anshul Singh ◽  
Cynthia Kaur ◽  
Akanksha Gupta
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Tongue Base ◽  
Malignant Degeneration ◽  
Neck Swelling ◽  
Cervical Metastasis ◽  
Diagnostic Dilemma ◽  
Branchial Cleft

Metastasis of head neck squamous cell carcinoma to regional deep cervical nodes is a common and usually are bony hard, solid. But sometimes they may present as a cystic mass which makes it a diagnostic challenge, in absence of evident primary, for the treating doctor. Previously they have been labeled as cancers of branchial cleft cysts which have undergone malignant degeneration. With the advancement in understanding of tumor pathophysiology most researchers now have concluded that these are tumors from tissue of waldeyer’s ring which have the potential of producing cystic cervical metastasis. : A 57-year-old male presented to our department with a right side slow growing neck swelling for 2 years. The rest of ear, nose, throat examination was normal. The fine needle aspiration cytology revealed clear fluid. The diagnosis of branchial cleft cyst was made and patient counselled for surgery for benign lesion. After a period of one month the patient presented with change in voice, difficulty in swallowing and another swelling on left side of the neck. FNAC from the left side swelling revealed metastatic squamous cell carcinoma and PET-CT revealed a tongue base growth. Patient underwent an excision of growth from tongue base and neck dissection on both sides. Even for cystic neck swelling in an adult over 40 years of age, the possibility of malignancy should be kept, until proven otherwise.

scholarly journals Concurrent Inverted Papilloma and Squamous Cell Carcinoma with Intradural Extension Presenting with Frontal Lobe Syndrome

2021 ◽  
Author(s):  
Abdul Jaleel ◽  
Pavithran V. M. ◽  
Shanavas Cholakkal ◽  
Vineeth Kadangot Kuthampulli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Frontal Lobe ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Lateral Wall ◽  
Inverted Papilloma ◽  
Intracranial Extension ◽  
Rare Presentation ◽  
Frontal Lobe Syndrome

Abstract Inverted papilloma is an uncommon tumor mostly arising from the lateral wall of the nasal cavity and displays a benign but locally aggressive behavior. Intracranial extension is an extremely rare presentation of inverted papilloma. Extension occurs either as a benign lesion or due to malignant transformation. We report a case of concurrent inverted papilloma and squamous cell carcinoma presenting with epistaxis and recent-onset altered behavior and memory impairment. After literature review of similar cases having inverted papilloma with intracranial extension, we could identify a total of 12 cases, most of which were recurrences of a primary inverted papilloma that were resected before extension into the cranial cavity. Most cases were of extradural extension, and intradural spread resulted in poor prognosis on follow-up. Concurrent inverted papilloma and squamous cell carcinoma extending into the anterior cranial fossa and frontal lobe is a very rare clinical entity and can present as frontal lobe syndrome.

scholarly journals Porokeratosis with an Invasive Squamous Cell Carcinoma: A Case Report and Review of Literature

2014 ◽  
Vol 32 (1) ◽  
pp. 31-36
Author(s):  
M Nessa ◽  
L Khondker ◽  
MA Bari ◽  
MSI Khan ◽  
M Rahman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Granular Layer ◽  
Malignant Degeneration ◽  
Invasive Squamous Cell Carcinoma ◽  
Review Of Literature ◽  
Large Plaque ◽  
Cornoid Lamella ◽  
Multiple Nodules

Porokeratosis is a clonal disorder of epidermal keratinization, which is characterized by hyperkeratotic papules or plaques that are surrounded by a thread-like elevated border. The histopathologic hallmark of porokeratosis is the cornoid lamella, which is a thin column of parakeratosis that overlies a thin or absent granular layer and that corresponds to the raised, hyperkeratotic border. Porokeratosis has five clinical types and malignant degeneration has been described in all forms of porokeratosis. We report a forty five year old farmer with a large plaque in chest for 30 years and multiple nodules within the large plaque for 2 years. A section of skin from margin of the plaque reveals histopathological features of porokeratosis and section from nodules reveals an invasive squamous cell carcinoma. To the best of our knowledge, this is the first reported case of porokeratosis transformed to squamous cell carcinoma on Bangladesh. DOI: http://dx.doi.org/10.3329/jbcps.v32i1.21035 J Bangladesh Coll Phys Surg 2014; 32: 31-36

scholarly journals Gyulladás vagy daganat?

2021 ◽  
Vol 162 (15) ◽  
pp. 595-600
Author(s):  
Tamás Major ◽  
Krisztina Szarka ◽  
Zsófia Nagy ◽  
Ilona Kovács ◽  
Csaba Balog ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Age At Onset ◽  
Sudden Onset ◽  
Lateral Neck ◽  
Neck Masses ◽  
Branchial Cleft ◽  
Branchial Cleft Cysts

Összefoglaló. A lateralis cysticus nyaki terimék két leggyakoribb oka a branchiogen cysta és a cysticus nyaki áttét. Az átfedő lokalizáció (a leggyakrabban a IIA nyaki régióban), a betegek életkora és az esetenként hirtelen kezdet alapján a két leggyakoribb ok differenciáldiagnózisa nagy kihívást jelenthet. Egy hirtelen fellépő fájdalmas, bal oldali nyaki duzzanattal, dysphagiával és lázzal jelentkező 72 éves férfi esetét ismertetjük. A nyak komputertomográfiás vizsgálata egy 6 cm legnagyobb átmérőjű, vastag falú, többrekeszes cysticus terimét igazolt. Infektív branchiogen cysta lehetőségére gondolva az elváltozást eltávolítottuk. A szövettan azonban p16-pozitív laphámrákot igazolt. A primer tumort végül az ipsilateralis tonsilla palatina állományában sikerült azonosítani. A beteg definitív radioterápiában részesült, és 18 hónappal a diagnózis után tumormentes. A nyaki cystákon, az infektív nyaki cystákon és a cysticus metastasisokon kívül a humán papillómavírussal összefüggő szájgarati laphámrákok infektív cysticus vagy necroticus metastasisait is figyelembe kell venni a lateralis cysticus nyaki terimék differenciáldiagnózisában. Orv Hetil. 2020; 162(15): 595–600. Summary. Branchial cleft cysts and cystic neck metastases are the two most common causes of cystic lateral neck masses. Based on the overlapping location (neck level IIA), patient age at onset and the occasionally sudden onset, their differential diagnosis is challenging. We present a 72-year-old male presenting with a suddenly emerging painful, left-sided neck swelling, dysphagia and fever. Computed tomography showed a 6 cm thick-walled multicystic mass. With the suspected diagnosis of an infected branchial cleft cyst, the lesion was removed. Histology confirmed p16 positive squamous cell carcinoma. Primary tumor was identified in the ipsilateral palatine tonsil. Definive radiotherapy was performed and the patient is free of disease at the 18-month follow-up. Beyond pure and infected branchial cleft cysts and pure cystic metastases, infected cystic or necrotic metastasis of human papillomavirus associated oropharyngeal squamous cell carcinoma should be included in the differential diagnosis of cystic lateral neck lesions. Orv Hetil. 2021; 162(15): 595–600.

Squamous Cell Carcinoma in Solitary Laryngeal Papilloma

1980 ◽  
Vol 88 (6) ◽  
pp. 745-748 ◽  
Author(s):  
Milton G. Yoder ◽  
John G. Batsakis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
White Woman ◽  
Malignant Degeneration ◽  
Malignant Neoplasms ◽  
Laryngeal Papilloma ◽  
Previously Treated ◽  
Squamous Cell Papilloma

This case report of a 20-year-old white woman is the youngest patient with a documented squamous cell carcinoma in a solitary nonirradiated laryngeal papilloma. It is rare for malignant degeneration of solitary squamous cell papilloma to occur in a patient under the age of 40. This case is also unique in that most solitary laryngeal papilloma with or without neoplasm occur in males. Most reported malignant neoplasms in squamous papilloma have been previously treated with irradiation. Because approximately 2% to 3% of solitary laryngeal papilloma have malignant neoplasms, adequate biopsy of the lesion and thorough histologic examination must always be done.

p16 Expression in Keratoacanthomas and Squamous Cell Carcinomas of the Skin: An Immunohistochemical Study

2006 ◽  
Vol 130 (1) ◽  
pp. 69-73
Author(s):  
Emad Kaabipour ◽  
Helen M. Haupt ◽  
Jere B. Stern ◽  
Peter A. Kanetsky ◽  
Victoria F. Podolski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
Squamous Cell Carcinomas ◽  
Diagnostic Dilemma ◽  
Significant Difference ◽  
P16 Expression

Abstract Context.—Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma. Objective.—To determine if p16 expression is useful in the differential diagnosis of SCC and KA. Design.—We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses. Results.—A range of immunohistochemical p16 expression was seen in KAs and SCCs in terms of the thickness of lesional staining and the percentage of cells staining. No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses. Conclusions.—These findings suggest that p16 is not a useful marker to distinguish between KA and SCC, supporting the similarity between the 2 lesions; p16 alterations appear to play a role in the pathogenesis of both KA and SCC.

A HISTOPATHOLOGICAL STUDY OF LIMB LESIONS: RETROSPECTIVE STUDY AT RIMS, RANCHI

2021 ◽  
pp. 13-14
Author(s):  
Suraj Sinha ◽  
Suchitra Kumari ◽  
Rabindra Kumar Singh ◽  
Raj Kishor Kumar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Malignant Neoplasm ◽  
Pyogenic Granuloma ◽  
Epidermal Cyst ◽  
Histopathological Study ◽  
Bony Lesion

Limb lesions of skin, soft tissue and bone are commonly encountered. They include a multitude of non neoplastic, benign and malignant diseases ranging from lipoma to brosarcoma and from epidermal cyst to squamous cell carcinoma. An insight of the pattern of various limb diseases in relation to site, age, and type of lesion assists in better comprehension of differential diagnosis for histopathologists. A retrospective study of histopathologically diagnosed cases of Material & Methods: 47 limb lesion patients from June 2020 to May 2021 was undertaken. A total 47 cases included 28 male and 19 female, Results: 55% of cases belong to age group 21 to 50 years. 13 (28%) cases were of upper extremity and 34 (72%) from lower extremity. 15 (34%) cases were non-neoplastic, 13 (28%) were benign lesion and rest 19 (38%) were malignant lesions. Lower limb lesions are more common than Conclusion: upper limb lesions. Squamous cell carcinoma is the most common malignant neoplasm and lipoma is the most common benign disease of extremity. Pyogenic granuloma and epidermal cyst were found to be the most common non-neoplastic extremity lesions. Fibrosarcoma was the most common type of sarcoma observed in 9% cases. Chronic osteomyelitis was the most common bony lesion.

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