Comparison of Pregabalin Versus Placebo in Reduction of Pain due to Lumber Disc Herniation

✓ The authors review 531 consecutive operations for lumbar disc herniation performed on 496 patients by one neurosurgeon to determine the effect of prophylactic antibiotics upon postoperative wound infections. In this retrospective analysis 16 instances of sepsis were found, 11 considered to be major and five minor. In the 128 cases in which no antibacterial agents were given, 11 major and 1 minor infection occurred. Four minor infections developed in the 402 occasions when antibiotics were given in the perioperative period. Men had a significantly greater risk of developing infection than women. These data suggest that pre- and postoperative antibiotic therapy directed at a narrow spectrum of microorganisms reduced the incidence of significant wound infections in patients undergoing laminectomy for lumbar disc herniation.

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Hyperexcitability and sensitization of sodium channels of dorsal root ganglion neurons in a rat model of lumber disc herniation

European Spine Journal ◽

10.1007/s00586-015-4171-z ◽

2015 ◽

Vol 25 (1) ◽

pp. 177-185 ◽

Cited By ~ 13

Author(s):

Jun Yan ◽

Kang Zou ◽

Xiaofeng Liu ◽

Shufen Hu ◽

Qianliang Wang ◽

...

Keyword(s):

Dorsal Root Ganglion ◽

Sodium Channels ◽

Disc Herniation ◽

Rat Model ◽

Dorsal Root ◽

Dorsal Root Ganglion Neurons ◽

Lumber Disc Herniation ◽

Ganglion Neurons

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Feasibility and Efficacy of Percutaneous Lateral Lumbar Discectomy in the Treatment of Patients with Lumbar Disc Herniation: A Preliminary Experience

BioMed Research International ◽

10.1155/2015/378612 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6

Author(s):

Wenjin Jiang ◽

Bolin Sun ◽

Qirui Sheng ◽

Xuepeng Song ◽

Yanbo Zheng ◽

...

Keyword(s):

Lumbar Disc Herniation ◽

Disc Herniation ◽

Lumbar Disc ◽

Japanese Orthopaedic Association ◽

Japanese Orthopaedic Association Score ◽

Lumbar Discectomy ◽

Analog Scale ◽

Association Score ◽

Lumber Disc Herniation

Objective. This study was aimed at evaluating the effectiveness and safety of percutaneous lateral lumbar discectomy (PLLD) in treating patients with lumber disc herniation.Methods. A total of 183 patients with lumbar disc herniation were recruited to receive PLLD surgery from April 2006 to October 2011. All the adverse effects were recorded during the follow-up at 1, 3, 6, and 12 months after PLLD. The clinical outcomes were determined by visual analog scale and Japanese Orthopaedic Association score.Results. The surgery was performed successfully in all patients (102 males and 81 females aged from 21 to 66 years) with a mean 16.6-month follow-up (range from 26 to 65 months). No postoperative complications, including intestinal and vascular complications, nerve injuries, and postoperative infections, were associated with PLLD. At one month after surgery, visual analog scale (3.12±1.44versus6.76±2.31,P<0.05) was significantly lower than the baseline and was sustained until 24 months after surgery (3.25±1.78versus6.76±2.31,P<0.05). Besides that, Japanese Orthopaedic Association score (25.25±3.21versus11.78±2.38,P<0.05) was increased when compared to the baseline.Conclusions. PLLD was a promising, mini-invasive, and effective treatment for lumber disc herniation.

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Comparing the results of intradiscal ozone injection to treat different types of intervertebral disc herniation based on MSU classification

Interventional Neuroradiology ◽

10.1177/1591019918800458 ◽

2018 ◽

Vol 25 (1) ◽

pp. 111-116 ◽

Cited By ~ 1

Author(s):

Behnam Hosseini ◽

Mehrdad Taheri ◽

Kourosh Sheibani

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Intervertebral Disc ◽

Disc Herniation ◽

Intervertebral Disc Herniation ◽

Low Back ◽

Significant Difference ◽

Different Types ◽

Reduction Of Pain ◽

Ozone Injection

Purpose To evaluate the therapeutic efficacy of intradiscal ozone injection in reducing pain and improving patients’ performance in different types of intervertebral disc herniation based on Michigan State University (MSU) classification. Patients and methods Consecutive patients with low back pain and radiculopathy treated in our center with ozone chemonucleolysis from May 2017 through to January 2018 entered the study. Patients had a disc herniation classified as group 1-A, 2-A, 1-B, 2-B, 1-C, 2-C, 1-AB or 2-AB based on MSU classification in magnetic resonance imaging. In all patients entering the study the severity of pain was recorded according to the visual analog scale criteria before and one and three months after the end of treatment. Oswestry Low Back Pain Disability Index (ODI) was used to compare patients’ performance before and after the treatment. Results In total 128 patients (60 females and 68 males) with mean age of 40.1 ± 10.7 entered the study. The patients were divided into eight groups based on MSU classification each including 16 patients. The reduction of pain severity and ODI score compared to baseline was statistically significant in all groups both in the first month and the third month after treatment. There was also a statistically significant difference between groups regarding the reduction of pain and ODI score indicating significantly worse treatment outcomes in groups 1-C, 2-C and 2-AB. Conclusion Based on our findings it seems that MSU classification can be used in patients’ selection to achieve the best treatment outcome after intradiscal ozone injection among patients with lumbar disc herniation.

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