scholarly journals A possible protective role for Bacillus Calmette-Guérin therapy in urinary bladder cancer in the era of COVID-19: a brief report

2021 ◽  
Vol 10 (2) ◽  
pp. 191
Author(s):  
Solmaz Ohadian Moghadam ◽  
Behzad Abbasi ◽  
Ali Nowroozi ◽  
Erfan Amini ◽  
Mohammad Reza Nowroozi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Urinary Bladder Cancer ◽  
Protective Role ◽  
Bacillus Calmette Guerin

A case of disseminated Mycobacterium bovis 2 years post-intravesicular Bacillus Calmette-Guérin therapy for superficial urinary bladder cancer

2017 ◽  
Vol 47 (7) ◽  
pp. 820-823 ◽  
Author(s):  
Alexander R. L. Robinson ◽  
Rajeswari Radhakrishnan ◽  
Robert Horvath ◽  
Sushil Pandey
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Mycobacterium Bovis ◽  
Urinary Bladder Cancer ◽  
Bacillus Calmette Guerin

scholarly journals Tuberculosis Complications After BCG Treatment for Urinary Bladder Cancer

Medicina ◽  
2012 ◽  
Vol 48 (11) ◽  
pp. 82 ◽  
Author(s):  
Albinas Naudžiūnas ◽  
Rūta Juškaitė ◽  
Indrė Žiaugrytė ◽  
Alvydas Unikauskas ◽  
Eglė Varanauskienė ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bladder Cancer ◽  
Surgical Treatment ◽  
Urinary Bladder ◽  
Urinary Bladder Cancer ◽  
Pulmonary Diseases ◽  
Bacillus Calmette Guerin ◽  
History Of ◽  
Muscle Invasive ◽  
Bcg Instillation

Bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis that has been effectively used in the treatment of non-muscle invasive bladder carcinoma. The complications of this treatment are uncommon, and the causes of dissemination are still discussed. We report a case of disseminated tuberculosis in a 66-year-old smoking man without a history of pulmonary diseases, who underwent immunotherapy with BCG after the initial surgical treatment of bladder cancer. After the last BCG instillation, he developed a fever. The diagnosis of sepsis was not confirmed, and miliary pulmonary tuberculosis was suspected. The diagnosis was confirmed by clinical manifestation, computed tomography of the lungs, and histological examination.

scholarly journals Serum level and single-nucleotide polymorphisms of toll-like receptor-7 among urinary bladder cancer Iraqi patients

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Rasha M. A. Al-Humairi ◽  
Muna T. Al-Musawi ◽  
Ali H. Ad’hiah
Keyword(s):  
Bladder Cancer ◽  
Serum Level ◽  
Urinary Bladder ◽  
Single Nucleotide Polymorphisms ◽  
Mitomycin C ◽  
Urinary Bladder Cancer ◽  
Nucleotide Polymorphisms ◽  
Bacillus Calmette Guerin ◽  
Toll Like Receptor ◽  
Single Nucleotide

Abstract Background Toll-like receptor 7 (TLR7), a member of TLR family, plays a pivotal role in pathogenesis of different malignancies. Among these is urinary bladder cancer (UBC), which has not been extensively studied. Therefore, it was aimed to determine TLR7 serum level in UBC patients and evaluate its association with some demographic and clinicopathological characteristics. In addition, four TLR7 single-nucleotide polymorphisms (SNPs: rs179018, rs179019, rs179020, and rs179021) were investigated to determine their susceptibility role in UBC and inspect SNP’s impact on TLR7 level. Sixty-six UBC Iraqi patients were enrolled in this case-control study. Two control samples were also involved, 40 urinary tract infection (UTI) patients, and 48 healthy control subjects. Results Male gender, older age, and cigarette-smoking are risk factors for UBC. TLR7 level showed a significant decreased median in UBC patients compared to UTI patients or control (1.4 vs. 8.1 and 9.5 ng/ml, respectively; p < 0.001). The decrease was more pronounced in males, age group ≥ 48 years, cigarette-smokers, alcohol non-consumers, clinical stages I–II, and superficial tumor, as well as patients with family history of cancer and untreated patients. Mitomycin C and Bacillus Calmette–Guérin therapies tended to increase TLR7 level. Among the four investigated SNPs, only rs179019 C allele showed significantly uncorrected increased frequency in UBC males compared to control males (p = 0.038), while among UTI females, C allele frequency maintained a significantly corrected decreased frequency compared to control females (p = 0.005). Some SNPs influenced serum level of TLR7, but a significant impact was recorded for rs179019 in UTI females (p = 0.006). Conclusions Downregulation of TLR7 is suggested to have a role in etiology and pathogenesis of UBC, especially the male, elderly and smoker patients. Mitomycin C and Bacillus Calmette–Guérin may enhance TLR7 production in the blood of UBC patients. TLR7 SNPs are suggested to influence susceptibility to develop UBC, and their potential in impacting TLR7 serum level is augmented.

777: Tissue Microarray Analysis of pAkt, PTEN and L-Plastin in Urinary Bladder Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 211-211
Author(s):  
Loleta D. Harris ◽  
Tomasz Tuziak ◽  
Jorge De Lo Cerda ◽  
Anita L. Sabichi ◽  
Ying Yang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Tissue Microarray ◽  
Microarray Analysis ◽  
Urinary Bladder Cancer ◽  
Tissue Microarray Analysis
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