Leptin activates maturation promoting factor through protein 34 cell devision cycle 2 phosphorilation by cell devision cycle 25A

2013 ◽  
Vol 4 (1) ◽  
pp. 42-50
Author(s):  
Pieter Kakisina ◽  
Gatot Ciptadi ◽  
Rasjad Indra ◽  
Sasmito Djati ◽  
Sutiman B. Sumitro
Keyword(s):  
Maturation Promoting Factor

c-erbB2andc-mybinduce oocyte maturationviaactivation of maturation promoting factor (MPF)

2010 ◽  
Vol 34 (8) ◽  
pp. S15-S15
Author(s):  
Yue Hui Zheng ◽  
Li‑Ping Zheng ◽  
Fang Li ◽  
Jian Huang ◽  
Lei Wu
Keyword(s):  
Maturation Promoting Factor

scholarly journals Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes.

1994 ◽  
Vol 269 (31) ◽  
pp. 20201-20207 ◽  
Author(s):  
O. Mulner-Lorillon ◽  
O. Minella ◽  
P. Cormier ◽  
J.P. Capony ◽  
J.C. Cavadore ◽  
...  
Keyword(s):  
Xenopus Oocytes ◽  
Elongation Factor ◽  
Maturation Promoting Factor

scholarly journals Cell Coupling and Maturation-Promoting Factor Activity in In Vitro-Matured Prepubertal and Adult Sheep Oocytes1

2001 ◽  
Vol 65 (1) ◽  
pp. 247-252 ◽  
Author(s):  
S. Ledda ◽  
L. Bogliolo ◽  
G. Leoni ◽  
S. Naitana
Keyword(s):  
Factor Activity ◽  
Cell Coupling ◽  
Adult Sheep ◽  
Maturation Promoting Factor

scholarly journals Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

Cell ◽  
1993 ◽  
Vol 73 (7) ◽  
pp. 1393-1402 ◽  
Author(s):  
Sandra L. Holloway ◽  
Michael Glotzer ◽  
Randall W. King ◽  
Andrew W. Murray
Keyword(s):  
Maturation Promoting Factor

Maturation promoting factor in ascidian oocytes is regulated by different intracellular signals at meiosis I and II

Development ◽  
1996 ◽  
Vol 122 (7) ◽  
pp. 1995-2003 ◽  
Author(s):  
G.L. Russo ◽  
K. Kyozuka ◽  
L. Antonazzo ◽  
E. Tosti ◽  
B. Dale
Keyword(s):  
Kinase Activity ◽  
Phase 1 ◽  
Polar Body ◽  
Calcium Transients ◽  
Phase 2 ◽  
Phase 3 ◽  
First Polar Body ◽  
Second Polar Body ◽  
Polar Body Extrusion ◽  
Maturation Promoting Factor

Using the fluorescent dye Calcium Green-dextran, we measured intracellular Ca2+ in oocytes of the ascidian Ciona intestinalis at fertilization and during progression through meiosis. The relative fluorescence intensity increased shortly after insemination in a single transient, the activation peak, and this was followed by several smaller oscillations that lasted for approximately 5 minutes (phase 1). The first polar body was extruded after the completion of the phase 1 transients, about 9 minutes after insemination, and then the intracellular calcium level remained at baseline for a period of 5 minutes (phase 2). At 14 minutes postinsemination a second series of oscillations was initiated that lasted 11 minutes (phase 3) and terminated at the time of second polar body extrusion. Phases 1 and 3 were inhibited by preloading oocytes with 5 mM heparin. Simultaneous measurements of membrane currents, in the whole-cell clamp configuration, showed that the 1–2 nA inward fertilization current correlated temporally with the activation peak, while a series of smaller oscillations of 0.1-0.3 nA amplitude were generated at the time of the phase 3 oscillations. Biochemical characterization of Maturation Promoting Factor (MPF) in ascidian oocytes led to the identification of a Cdc2-like kinase activity. Using p13suc1-sepharose as a reagent to precipitate the MPF complex, a 67 kDa (67 × 10(3) Mr) protein was identified as cyclin B. Histone H1 kinase activity was high at metaphase I and decreased within 5 minutes of insemination reaching a minimum level during phase 2, corresponding to telophase I. During phase 3, H1 kinase activity increased and then decayed again during telophase II. Oocytes preloaded with BAPTA and subsequently inseminated did not generate any calcium transients, nonetheless H1 kinase activity decreased 5 minutes after insemination, as in the controls, and remained low for at least 30 minutes. Injection of BAPTA during phase 2 suppressed the phase 3 calcium transients, and inhibited both the increase in H1 kinase activity normally encountered at metaphase II and second polar body extrusion.

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