scholarly journals Sepsis Mortality in Critical Care and Prior Statin Therapy: A Retrospective Cohort Study in Central Argentina

Author(s):  
Liberth Incahuanaco Paricahua
2021 ◽  
Vol 10 ◽  
pp. 204800402110310
Author(s):  
Joseph A Nardolillo ◽  
Joel C Marrs ◽  
Sarah L Anderson ◽  
Rebecca Hanratty ◽  
Joseph J Saseen

Objective To compare statin prescribing rates between intermediate-risk people living with human immunodeficiency virus (HIV; PLWH) and intermediate-risk patients without a diagnosis of HIV for primary prevention of atherosclerotic cardiovascular disease (ASCVD). Methods Retrospective cohort study . Electronic health record data were used to identify a cohort of PLWH aged 40–75 years with a calculated 10-year ASCVD risk between 7.5%-19.9% as determined by the Pooled Cohort Equation (PCE). A matched cohort of primary prevention non-HIV patients was identified. The primary outcome was the proportion of PLWH who were prescribed statin therapy compared to patients who were not living with HIV and were prescribed statin therapy Results 81 patients meeting study criteria in the PLWH cohort were matched to 81 non-HIV patients. The proportion of patients prescribed statins was 33.0% and 30.9% in the PLWH and non-HIV cohorts, respectively (p = 0.74). Conclusion and relevance: This study evaluated statin prescribing in PLWH for primary prevention of ASCVD as described in the 2018 AHA/ACC/Multisociety guideline. Rates of statin prescribing were similar, yet overall low, among intermediate-risk primary prevention PLWH compared to those not diagnosed with HIV.


2020 ◽  
Vol 4 (4) ◽  
pp. 123
Author(s):  
Abdulmajeed Alhaidari ◽  
Maram Busuhail ◽  
Sara Alsultan ◽  
Sultan Alshammari ◽  
Abdullah Alshimemeri

2019 ◽  
Vol 39 (4) ◽  
pp. 13-19 ◽  
Author(s):  
Jenny Alderden ◽  
Yunchuan Lucy Zhao ◽  
Donna Thomas ◽  
Ryan Butcher ◽  
Brenda Gulliver ◽  
...  

2021 ◽  
Vol 331 ◽  
pp. e257
Author(s):  
S. Greco ◽  
F. Luciani ◽  
E. Giorgini ◽  
A. D'Amuri ◽  
M. Lopreiato ◽  
...  

2012 ◽  
Vol 15 (7) ◽  
pp. A568
Author(s):  
H. Amital ◽  
D. Weitzman ◽  
G. Chodick ◽  
V. Shalev

Critical Care ◽  
2011 ◽  
Vol 15 (4) ◽  
pp. R171 ◽  
Author(s):  
Armand Mekontso Dessap ◽  
Islem Ouanes ◽  
Nerlep Rana ◽  
Beatrice Borghi ◽  
Christophe Bazin ◽  
...  

Critical Care ◽  
2014 ◽  
Vol 18 (3) ◽  
pp. R112 ◽  
Author(s):  
Varinder Randhawa ◽  
Syed Sarwar ◽  
Sandra Walker ◽  
Marion Elligsen ◽  
Lesley Palmay ◽  
...  

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A669
Author(s):  
Timothy Kable ◽  
Iaswarya Ganapathiraju ◽  
Samuel DuMontier ◽  
Rebecca Sabates ◽  
Jonathan Wadle ◽  
...  

2016 ◽  
Vol 44 (12) ◽  
pp. 215-215
Author(s):  
Dipayan Chaudhuri ◽  
Kwadwo Kyeremanteng ◽  
Gianni D’Egidio

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Nader Habib Bedwani ◽  
William English ◽  
Christopher Smith ◽  
Shailendra Singh ◽  
Paul Vulliamy ◽  
...  

Abstract Aims A better understanding of patient monitoring and outcomes is required following emergency laparotomy. We aimed to evaluate recovery following emergency laparotomy during the ‘first wave’ of the COVID-19 pandemic and assess for COVID-19-associated coagulopathy in this group. Methods We performed a single-centre, retrospective cohort study on adult patients undergoing emergency laparotomy from 23rdMarch – 16thMay 2020 comparing patients with or without suspected or confirmed SARS-CoV-2. Main outcome measures included; 30-day mortality, post-operative respiratory failure, ARDS and other complications, critical care admission and length of stay (CCLOS) and total length of stay (LOS). Laboratory results were collected for three days post-operatively including platelet counts and clotting screen. Results 33 patients undergoing 36 emergency laparotomies were included, of which 9 had confirmed or suspected COVID-19. Patients with COVID-19 were more likely to have severe complications (Clavien-Dindo grade ≥3) (9/9 vs 5/24; p < 0.001), post-operative respiratory failure (9/9 vs 2/24; p < 0.001), ARDS (3/9 vs 0/24; p = 0.015) and need for critical care stay (9/9 vs 12/24; p = 0.012) with a longer LOS and CCLOS (17 vs 7 days; p = 0.004 and 6 vs 1 day; p < 0.001 respectively). Platelet counts were consistently lower on all peri-operative days and patients had a higher incidence of coagulopathy (7/11 vs 3/17; p = 0.020). Conclusions Emergency laparotomy is associated with increased post-operative morbidity in patients with confirmed or suspected COVID-19 with increased respiratory complications and critical care stay. Post-operative patients with COVID-19 show mildly reduced platelet counts and deranged clotting that may be part of a COVID-19-associated coagulopathy.


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