scholarly journals Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: a retrospective cohort study

Critical Care ◽  
2011 ◽  
Vol 15 (4) ◽  
pp. R171 ◽  
Author(s):  
Armand Mekontso Dessap ◽  
Islem Ouanes ◽  
Nerlep Rana ◽  
Beatrice Borghi ◽  
Christophe Bazin ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Cohort Study ◽  
Statin Therapy ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Sepsis And Septic Shock

Prognostic value of lactate levels and lactate clearance in sepsis and septic shock with initial hyperlactatemia: a retrospective cohort study according to the Sepsis-3 definitions

2020 ◽  
Author(s):  
Seong Geun Lee ◽  
Juhyun Song ◽  
Han-jin Cho ◽  
Sungwoo Moon ◽  
Dae Won Park ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Prognostic Value ◽  
Area Under The Curve ◽  
Lactate Clearance ◽  
Prediction Of Mortality ◽  
Lactate Levels ◽  
Sepsis And Septic Shock

Abstract Background: This study evaluated the prognostic value of lactate levels and lactate clearance for the prediction of mortality in sepsis and septic shock patients.Methods: We performed a retrospective cohort study of sepsis and septic shock patients with initial lactate levels of ≥2 mmol/L. All patients met the Sepsis-3 definitions. The prognostic value of 6-hour lactate levels, lactate clearance, 6-hour lactate metrics (≥2 mmol/L), and lactate clearance metrics (<10%, <20%, and <30%) was evaluated. We compared the sensitivity and specificity between metrics.Results: Of the 363 sepsis and septic shock patients, 148 died (30-day mortality: 40.8%). Nonsurvivors had significantly higher 6-hour lactate levels and lower lactate clearance than those of survivors. Six-hour lactate levels and lactate clearance were associated with 30-day mortality after adjusting for potential confounders (odds ratio, 1.191 [95% confidence interval (CI), 1.097–1.294] and 0.989 [0.983–0.995], respectively). Six-hour lactate levels had better prognostic value than lactate clearance (area under the curve, 0.720 [95% CI, 0.670–0.765] vs. 0.656 [0.605–0.705]; p = 0.018). A 6-hour lactate level of ≥3.5 mmol/L and a lactate clearance of <24.4% were the optimal cutoff values in predicting the 30-day mortality. The prognostic value of 6-hour lactate metrics and lactate clearance metrics did not differ. Six-hour lactate levels (≥2 mmol/L) had the highest sensitivity (89.2%).Conclusions: Six-hour lactate levels proved to be more accurate in predicting 30-day mortality than lactate clearance.

Do Sepsis-3 Criteria Facilitate Earlier Recognition of Sepsis and Septic Shock? A Retrospective Cohort Study

Shock ◽  
2019 ◽  
Vol 51 (3) ◽  
pp. 306-311 ◽  
Author(s):  
Christian S. Scheer ◽  
Sven-Olaf Kuhn ◽  
Christian Fuchs ◽  
Marcus Vollmer ◽  
Arnd Modler ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Sepsis And Septic Shock

Body Habitus and Risk of Mortality in Pediatric Sepsis and Septic Shock: A Retrospective Cohort Study

2019 ◽  
Vol 210 ◽  
pp. 178-183.e2 ◽  
Author(s):  
Patrick A. Ross ◽  
Margaret J. Klein ◽  
Tuan Nguyen ◽  
Dennis Leung ◽  
Robinder G. Khemani ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Body Habitus ◽  
Risk Of Mortality ◽  
Pediatric Sepsis ◽  
Sepsis And Septic Shock

scholarly journals The clinical outcomes and biomarker features of severe sepsis/ septic shock with severe neutropenia: a retrospective cohort study

2021 ◽  
Vol 10 (3) ◽  
pp. 464-473
Author(s):  
Fan Yin ◽  
Yue-Ling Xi ◽  
Ying Wang ◽  
Bi-Ru Li ◽  
Juan Qian ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Cohort Study ◽  
Clinical Outcomes ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Severe Neutropenia
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