scholarly journals Dexmedetomidine and Fentanyl for Postoperative Analgesia in Patients Undergoing Abdominal Surgery: Randomised Controlled Trial

2021 ◽  
Author(s):  
Prashant Sachan ◽  
Prem Raj Singh ◽  
Sateesh Verma ◽  
Brij Bihari Kushwaha
Keyword(s):  
Postoperative Pain ◽  
Randomised Controlled Trial ◽  
Abdominal Surgery ◽  
Postoperative Analgesia ◽  
Pain Control ◽  
Controlled Trial ◽  
Haemodynamic Stability ◽  
Group A ◽  
Group B ◽  
Randomised Controlled

Introduction: Pain control is an important factor for postoperative recovery. Many drugs have been studied for effectiveness of postoperative analgesia. Fentanyl is a conventional drug and dexmedetomidine is one of the emerging drugs used for analgesia and postoperative pain control. Aim: To compare the effect of fentanyl and dexmedetomidine on pain control and haemodynamic stability. Materials and Methods: A randomised controlled trial was conducted on 60 patients (30 each group) undergoing for abdominal surgery, between January 2019 to January 2020. Group A received fentanyl loading dose 2 μg/kg I.V. followed by 0.5 μg/kg/hr infusion and group B received dexmedetomidine loading 1 μg/kg over 10 minutes followed by maintenance 0.5 μg/kg/hr infusion. Infusion was continued up to four hours during surgery and till eight hours of postoperative in both groups. Haemodynamic parameters {Heart Rate (HR), Mean Arterial Pressure (MAP)} were recorded after start of study drug infusion, after intubation, then every 15 minutes till 1 hour, then every 30 minutes till end of surgery and after extubation. In postoperative period, HR and MAP were recorded at interval of one hour till eight hours after extubation and postoperative analgesia was assessed by Visual Analogue Scale (VAS) at interval of one hour till eight hours. Present study used descriptive statistical analysis for data analysis. Analysis of variance (ANOVA) was used to compare data between two groups. Chi-square test was used to find the significance of difference on categorical scale between two groups. Results: This study showed that group-B had significantly less VAS score most of time in recovery period as compared to group-A (1.97±0.18 vs 2.10±0.31 at eight hours postoperative). HR, MAP was found significantly less all the time during surgery and most of the time postoperatively in group-B (p-value <0.05). Conclusion: Intravenous infusion of dexmedetomidine can be better for controlling postoperative pain and perioperative haemodynamic stability as compared to infusion of fentanyl in patients undergoing abdominal surgeries.

scholarly journals Role of Saccharomyces boulardii and Bacillus clausii in reducing the duration of diarrhea: a three-armed randomised controlled trial

2018 ◽  
Vol 5 (5) ◽  
pp. 1811 ◽  
Author(s):  
Vidjeadevan D. ◽  
Vinoth S. ◽  
Ramesh S.
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Saccharomyces Boulardii ◽  
Major Public Health Problem ◽  
Duration Of Stay ◽  
Bacillus Clausii ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Randomised Controlled

Background: Diarrhea is a major public health problem. Probiotics have been recommended as an add-on therapy for the treatment of diarrhea. Recently Saccharomyces boulardii and Bacillus clausii, yeast and spore forming bacilli are among the probiotics in use for diarrheal disorder.Methods: This was a three armed randomised controlled trial conducted in pediatrics department, in a tertiary level care at Chidambaram. The randomisation was done using permuted blocks method. Of the three groups, Group A received ORS and zinc; Group B ORS, zinc and S. boulardii and Group C ORS, zinc and B. clausii. The outcome variables included duration of diarrhea and duration of stay in hospital.Results: The duration of diarrhea decreased significantly in Group B and C than Group A. Both the probiotics had similar effect in reducing the duration of diarrhea. There was no significant difference in duration of stay at hospital between the groups.Conclusions: Addition of probiotics as an add-on therapy would aid in decreasing the duration of diarrhea rather than giving ORS and zinc alone. The duration of stay in hospital was unaffected by the change in regimen of treatment.

Effectiveness of local anesthetic application methods in postoperative pain control in laparoscopic cholecystectomies; a randomised controlled trial

2021 ◽  
Vol 95 ◽  
pp. 106134
Author(s):  
Anil Ergin ◽  
Mehmet Timuçin Aydin ◽  
Hüseyin Çiyiltepe ◽  
Aziz Bora Karip ◽  
Mehmet Mahir Fersahoğlu ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Randomised Controlled Trial ◽  
Local Anesthetic ◽  
Pain Control ◽  
Controlled Trial ◽  
Postoperative Pain Control ◽  
Application Methods ◽  
Randomised Controlled

scholarly journals Normal saline flushes performed once daily maintain peripheral intravenous catheter patency: a randomised controlled trial

2015 ◽  
Vol 100 (7) ◽  
pp. 700-703 ◽  
Author(s):  
Silvana Schreiber ◽  
Chiara Zanchi ◽  
Luca Ronfani ◽  
Anna Delise ◽  
Alessandra Corbelli ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Normal Saline ◽  
Controlled Trial ◽  
Nursing Time ◽  
Catheter Patency ◽  
Registration Number ◽  
Peripheral Intravenous Catheter ◽  
Group A ◽  
Group B ◽  
Randomised Controlled

ObjectiveRecent evidence supports the use of normal saline flushes in place of heparin to maintain the patency of peripheral intravenous locks (IVLs); however, there are no data regarding the recommended flush frequency.Study designThis was an open, non-inferiority, randomised controlled trial. Children with IVLs, aged 1–17 years, were randomly assigned to receive saline flushing every 12 h (group A) or every 24 h (group B). The main outcome was the maintenance of catheter patency.ResultsFour hundred patients were randomised; 198 subjects were analysed in the 12 h group and 199 in the 24 h group (three patients were lost at follow-up). Occlusion occurred in 15 children (7.6%) in group A versus 9 (4.5%) in group B (p=0.21). The difference in catheter patency was +3.1% in favour of the 24 h group (95% CI −1.6% to 7.7%), showing the non-inferiority of the 24 h procedure (the non-inferiority margin was set at −4%). Catheter-related complications were not different between the two groups (12.1% in group A vs 9.5% in group B; p=0.42).ConclusionsA flushing procedure with one flush per day allows maintenance of catheter patency without an increase in catheter-related complications. We propose a simplification of the flushing procedure with only one flush per day, thereby reducing costs (materials use and nursing time), labour and unnecessary manipulation of the catheters which can cause distress in younger children and their parents.Trial registration numberThe study is registered in the international database ClinicalTrial.gov under registration number NCT02221024.

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