Comparison of the Effectiveness of Monitoring Cisplatin-Induced Ototoxicity with Extended High-Frequency Pure-Tone Audiometry or Distortion-Product Otoacoustic Emission

AbstractObjectives:This study aimed to: understand the effect that high intensity noise associated with drilling (during otological surgery) has on hearing in the contralateral ear; determine the nature of hearing loss, if any, by establishing whether it is temporary or persistent; and examine the association between hearing loss and various drill parameters.Methods:A prospective clinical study was carried out at a tertiary centre. Thirty patients with unilateral cholesteatoma and normal contralateral hearing were included. Patients were evaluated pre-operatively and for five days following surgery using high frequency pure tone audiometry, and low and high frequency transient evoked and distortion product otoacoustic emission testing.Results:The findings revealed statistically significant changes in distortion product otoacoustic emissions at high frequencies (p = 0.016), and in transient evoked otoacoustic emissions at both low and high frequencies (p = 0.035 and 0.021, respectively). There was a higher statistical association between otoacoustic emission changes and cutting burrs compared with diamond burrs.Conclusion:Drilling during mastoid surgery poses a threat to hearing in the contralateral ear due to noise and vibration conducted transcranially.

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Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure

The Journal of Laryngology & Otology ◽

10.1017/s0022215115002790 ◽

2015 ◽

Vol 129 (12) ◽

pp. 1174-1181 ◽

Cited By ~ 4

Author(s):

N Wooles ◽

M Mulheran ◽

P Bray ◽

M Brewster ◽

A R Banerjee

Keyword(s):

Otoacoustic Emissions ◽

Pure Tone ◽

Noise Exposure ◽

Outer Hair Cell ◽

Cell Function ◽

Pure Tone Audiometry ◽

Otoacoustic Emission ◽

Distortion Product Otoacoustic Emissions ◽

Distortion Product Otoacoustic Emission ◽

Distortion Product

AbstractObjective:To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit.Methods:A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obtained sequentially during mandatory screening of brickyard workers (n = 16). Individual pure tone audiometry thresholds were compared with distortion product otoacoustic emission amplitudes, and a correlation of these measurements was conducted.Results:Pure tone audiometry threshold elevation was identified in 13 out of 16 workers. When distortion product otoacoustic emission amplitudes were compared with pure tone audiometry thresholds at matched frequencies, no evidence of a robust relationship was apparent. Seven out of 16 workers had substantial distortion product otoacoustic emissions with elevated pure tone audiometry thresholds.Conclusion:No clinically relevant predictive relationship between distortion product otoacoustic emission amplitude and pure tone audiometry threshold was apparent. These results do not support the replacement of pure tone audiometry with distortion product otoacoustic emissions in screening. Distortion product otoacoustic emissions at frequencies associated with elevated pure tone audiometry thresholds are evidence of intact outer hair cell function, suggesting that sites distinct from these contribute to auditory deficit following ototrauma.

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High-Frequency Cochlear Amplifier Dysfunction: A Dominating Contribution to the Cognitive-Ear Link

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.767570 ◽

2022 ◽

Vol 13 ◽

Author(s):

Yao Wang ◽

Xiao Li ◽

Fuxin Ren ◽

Siqi Liu ◽

Wen Ma ◽

...

Keyword(s):

Linear Regression ◽

High Frequency ◽

Regression Models ◽

Pure Tone ◽

Otoacoustic Emission ◽

Cochlear Amplifier ◽

Linear Regression Models ◽

Distortion Product Otoacoustic Emission ◽

Distortion Product ◽

Multiple Linear Regression Models

Objective: The objective of this study was to investigate the role of the high-frequency cochlear dysfunction in the cognitive-ear link.Methods: Seventy-four presbycusis patients (PC group) and seventy-one age-, sex-, and education-level matched normal hearing controls (NH group) were recruited in this study. Participants underwent a battery of cognitive tests estimated by Montreal Cognitive Assessment (MoCA), Stroop Color-Word Interference Test (Stroop), Symbol Digit Modalities Test (SDMT), Auditory Verbal Learning Test (AVLT), and Trail-Making Test (TMT-A and B), as well as auditory tests including distortion product otoacoustic emission (DPOAE), pure tone (PT) thresholds, and speech reception thresholds (SRT). Data were analyzed using the factor analysis, partial correlation analysis, multiple linear regression models, and mediation models.Results: Distortion product otoacoustic emission detection amplitudes and PT thresholds performed worse gradually from low to high frequencies in both the NH and PC groups. High-frequency DPOAE (H-DPOAE) was significantly correlated with cognitive domains in the PC group (AVLT: r = 0.30, p = 0.04; SDMT: r = 0.36, p = 0.01; Stroop: r = –0.32, p = 0.03; TMT-A: r = –0.40, p = 0.005; TMT-B: r = –0.34, p = 0.02). Multiple linear regression models showed that H-DPOAE predicted cognitive impairment effectively for aspects of memory (R2 = 0.27, 95% CI, 0.03 to 1.55), attention (R2 = 0.32, 95% CI, –6.18 to –0.40), processing speed (R2 = 0.37, 95% CI, 0.20 to 1.64), and executive function (TMT-A: R2 = 0.34, 95% CI, –5.52 to 1.03; TMT-B: R2 = 0.29, 95% CI, –11.30 to –1.12). H-DPOAE directly affected cognition and fully mediated the relationship between pure tone average (PTA)/SRT and cognitive test scores, excluding MoCA.Conclusion: This study has demonstrated that the high-frequency cochlear amplifier dysfunction has a direct predictive effect on the cognitive decline and makes a large contribution to the cognitive-ear link.

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Effects of Oxaliplatin, Carboplatin, and Cisplatin Across Treatment on High-Frequency Objective and Subjective Auditory Measures in Adults

Perspectives of the ASHA Special Interest Groups ◽

10.1044/persp2.sig6.17 ◽

2017 ◽

Vol 2 (6) ◽

pp. 17-38 ◽

Cited By ~ 6

Author(s):

Laura Dreisbach ◽

Melissa Ho ◽

Erin Reid ◽

Jonathan Siegel

Keyword(s):

High Frequency ◽

Otoacoustic Emission ◽

Distortion Product Otoacoustic Emission ◽

Chemotherapy Treatment ◽

Auditory Function ◽

Distortion Product ◽

Behavioral Thresholds ◽

Group Data ◽

Platinum Chemotherapy ◽

Early Damage

Platinum chemotherapies are often ototoxic, initially affecting the basal end of the cochlea. Thus, monitoring high-frequency auditory function is advised to reveal early damage. Objective measures of high-frequency auditory function are repeatable over time, but the sensitivity of these measures for monitoring patients receiving platinum derivatives have not been established. We monitored 13 patients across oxaliplatin, carboplatin, or cisplatin treatment using the highest frequencies with responses for each individual. Behavioral thresholds and distortion product otoacoustic emission (DPOAE) gross frequency (f2=16–2 kHz) and concentrated frequency (1/48 octave steps at the highest frequency with a present DPOAE) sweeps were monitored. DPOAE results indicated changes during treatment within individuals using absolute change criteria, as well as statistically significant differences across trial when analyzing group data. Changes varied depending on the drug administered. Behavioral thresholds changed less often than DPOAE measures and when changes were noted, they initially occurred at the highest frequencies monitored. Often, DPOAE changes occurred at frequencies which conventional equipment could not monitor (>8 kHz). Additionally, some changes were characterized by DPOAE level enhancements at conventional frequencies (<8 kHz), while levels at higher frequencies were reduced. Overall, objective high-frequency measures were sensitive to auditory changes in adults undergoing platinum chemotherapy treatment.

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Electrocochleography is More Sensitive than Distortion-Product Otoacoustic Emission Test for Detecting Noise-Induced Temporary Threshold Shift

Otolaryngology ◽

10.1016/j.otohns.2005.06.012 ◽

2005 ◽

Vol 133 (4) ◽

pp. 619-624 ◽

Cited By ~ 11

Author(s):

Jin Sook Kim ◽

Eui-Cheol Nam ◽

Sung Il Park

Keyword(s):

Sensitivity And Specificity ◽

Pure Tone Audiometry ◽

Otoacoustic Emission ◽

Threshold Shift ◽

Specific Information ◽

Temporary Threshold Shift ◽

Distortion Product Otoacoustic Emission ◽

Distortion Product ◽

Summating Potential ◽

A Prospective Study

OBJECTIVE: We investigated and compared the usefulness of the electrocochleography and distortion product otoacoustic emission tests for detecting the earliest noise-induced damage by analyzing the sensitivity and specificity of the 2 tests. STUDY DESIGN: A prospective study. METHODS: After listening to music at 90.3 ± 4.2 dB in the same night-club for 2 hours continuously, 23 healthy normal ears experienced a temporary threshold shift exceeding 5 dB. Pure-tone audiometry, the distortion product otoacoustic emission test, and electrocochleography were performed before, immediately after, and 24 hours after the exposure. RESULTS: Before exposure, the measured distortion product/noise floor was 9.8 ± 10.4, 23.5 ± 6.4, 18.7 ± 6.4, and 19.1 ± 5.6 dB sound pressure level (SPL) at frequencies of 1, 2, 3, and 4 kHz, respectively. Immediately after exposure, it decreased significantly at 2, 3, and 4 kHz to 16.6 ± 7.6, 12.5 ± 6.8, and 14.8 ± 7.7 dB SPL, respectively. Marked increases in the amplitude of the summating potential and summating potential/action potential ratio were recorded from 0.15 ± 0.06 to 0.32 ± 0.11 and 0.23 ± 0.06 to 0.44 ± 0.08, respectively. The respective sensitivity and specificity of electrocochleography were 76.7% to 88.5% and 91.0% to 100%. Those of the distortion product otoacoustic emission test were 54.8% to 62.2% and 75.5% to 87.0%, respectively. CONCLUSION: Electrocochleography appears to provide more sensitive and specific information than the distortion product otoacoustic emission test for detecting a noise-induced temporary threshold shift.

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Pemeriksaan Otoacoustic Emission (OAE) untuk menilai keberhasilan terapi metilprednisolon

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v49i1.285 ◽

2019 ◽

Vol 49 (1) ◽

pp. 1

Author(s):

Brastho Bramantyo ◽

Jenny Bashiruddin ◽

Widayat Alviandi ◽

Risdawati Risdawati

Keyword(s):

Systematic Review ◽

Pure Tone ◽

Signal To Noise Ratio ◽

Hearing Threshold ◽

Otoacoustic Emission ◽

Sudden Deafness ◽

Distortion Product Otoacoustic Emission ◽

Signal To Noise ◽

Cochrane Systematic Review ◽

Distortion Product

Latar belakang: Penatalaksanaan tuli mendadak menggunakan steroid sebagai terapi utama merupakan hasil konsensus terapi tuli mendadak tahun 2010 di Madrid-Spanyol dan Cochrane systematic review tahun 2009, yang saat ini diterapkan di Divisi Neurotologi Departemen Telinga Hidung Tenggorok-Kepala Leher Rumah Sakit Cipto Mangunkusumo. Evaluasi hasil pengobatan dilakukan dengan pemeriksaan audiometri dan Distortion Product Otoacoustic Emission (DPOAE). Pasien yang mengalami kesembuhan akan memperlihatkan peningkatan ambang dengar dan nilai Signal to Noise Ratio (SNR) emisi otoakustik. Tujuan: Mengevaluasi hasil terapi metilprednisolon dosis terbaru pada tuli mendadak dengan pemeriksaan DPOAE dan audiometri nada murni. Metode: Penelitian ini menggunakan desain pre dan post eksperimental. Diberikan terapi metilprednisolon 1 mg/kgBB dengan tapering off 20 mg setiap 5 hari. Dilakukan pemeriksaan DPOAE dan audiometri sebelum dan setelah terapi. Hasil: Total sampel yang diolah adalah 22 subjek. Penelitian ini mendapatkan perubahan yang bermakna nilai audiometri nada murni sebelum dan sesudah terapi pada semua frekuensi. Nilai SNR pada OAE sebelum dan setelah terapi rata-rata mengalami perubahan nilai pass, dengan perubahan nilai SNR pass terbanyak adalah pada frekuensi 8000 Hz (6 subjek). Tingkat perubahan ambang dengar sesudah terapi yang mengalami perbaikan paling banyak pada frekuensi 2000 Hz, 3000 Hz, 6000 Hz dengan masing-masing 16 subjek. Perbaikan emisi terjadi lebih awal dibandingkan perbaikan ambang dengar. Kesimpulan: Pada penelitian ini terdapat perubahan bermakna nilai audiometri, dan nilai DPOAE. Didapatkan hubungan bermakna perubahan SNR pada OAE dengan tingkat perubahan ambang dengar frekuensi 8000 Hz dan 10.000 Hz, setelah pengobatan metilprednisolon sesuai protokol penelitian ini. Background: Methylprednisolone as a drug of choice in sudden deafness was consented in Madrid, Spain 2010 and in Cochrane systematic review in 2009, and already applied in Neurotology Division, ENT Department Cipto Mangunkusumo Hospital. Sudden deafness treatment evaluation conducted by audiometry and Distortion Product Otoacoustic Emission (DPOAE) examinations. Hearing recovery could be assessed from the improvement of hearing threshold and Signal to Noise Ratio (SNR) of otoacoustic emission (OAE). Objective: To evaluate the current dose of methylprednisolone therapy for sudden deafness, by DPOAE and pure tone audiometry. Methods: This was a pre-post experimental study using methylprednisolone 1 mg/kg body weight tapered off 20 mg in every 5 days. DPOAE and audiometry examination were conducted pre and post therapy. Result: Total sample were 22 subjects. Significant improvement was seen in overall frequencies of audiometry examination. Pass result in SNR of OAE showed remarkable improvement in 8000 Hz (6 subjects). The level of pure tone threshold mainly increased in frequencies of 2000 Hz, 3000 Hz, and 6000 Hz, each 16 subjects. Improvement of the emision level occurred earlier than the hearing threshold. Conclusion: This study revealed significant improvement of audiometry threshold and OAE level. Significant correlation was found between SNR of OAE improvement with increased pure tone level in 8000 Hz and 10.000 Hz after methylprednisolone therapy according to the protocol of this study.

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Correlation between schroeder-phase effect and distortion product otoacoustic emission findings

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v15i1.1230 ◽

2016 ◽

Vol 15 (1) ◽

Author(s):

Nur Baizura Salahuddin ◽

Sarah Rahmat

Keyword(s):

Pure Tone Audiometry ◽

Otoacoustic Emission ◽

Outer Hair Cells ◽

Output Function ◽

Distortion Product Otoacoustic Emission ◽

Input Output ◽

Phase Effect ◽

Cochlear Function ◽

Distortion Product ◽

Effect Mechanism

Introduction: Schroeder-phase masking has been proven to be more sensitive than pure tone audiometry in detecting changes in cochlear function. Schroeder harmonic complexes with different phases have been observed to excite basilar membranes differently and give different masking abilities (‘phase effect’) when used as maskers. Previous theory suggested that phase effect was contributed by cochlear non-linearity of outer hair cells (OHC); however the theory was derived from behavioral observation alone. Therefore, this study aims to further investigate the cochlear non-linearity involvement in phase effect mechanism by measuring the Schroeder phase effect together with another electrophysiological test that measures the cochlear non-linearity function, i.e. Distortion Product Otoacoustic Emission (DPOAE). Methods: Twelve normal hearing and four sensorineural hearing loss subjects were recruited. Schroeder phase masking test was conducted and phase effect (using 75 dB A masker) at 1kHz and 2 kHz was measured. DPOAE was recorded at multiple intensities (45-75 dB SPL) for 1 kHz and 2 kHz, and slope of DPOAE input output function was measured. Correlation analysis was performed to find correlation between phase effect and slope of DPOAE input output function. Results: Result showed no significant correlation (p > 0.05) between phase effect and slope of DPOAE input output function. Conclusions: This findings suggest that Schroeder-phase effect may not be/ may not only be contributed by OHC’s cochlear non-linearity. This finding opens the possibility of other auditory functions’ involvement in phase effect mechanism, and contribute to better understanding towards auditory perceptions.

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High Frequency Pure Tone Audiometry and High Frequency Distortion Product Otoacoustic Emissions: A Correlational Analysis

10.15760/etd.1688 ◽

2000 ◽

Author(s):

Kimberly Lavoie

Keyword(s):

High Frequency ◽

Otoacoustic Emissions ◽

Pure Tone ◽

Pure Tone Audiometry ◽

Correlational Analysis ◽

Distortion Product Otoacoustic Emissions ◽

Distortion Product

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High-Frequency Distortion-Product Otoacoustic Emission Repeatability in a Patient Population

Ear and Hearing ◽

10.1097/aud.0000000000000465 ◽

2018 ◽

Vol 39 (1) ◽

pp. 85-100 ◽

Cited By ~ 9

Author(s):

Laura Dreisbach ◽

Erika Zettner ◽

Margaret Chang Liu ◽

Caitlin Meuel Fernhoff ◽

Imola MacPhee ◽

...

Keyword(s):

High Frequency ◽

Patient Population ◽

Otoacoustic Emission ◽

Distortion Product Otoacoustic Emission ◽

Distortion Product

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The Immediate and Long-Term Impact of Military Aircraft Noise on Hearing: A Cross-Sectional Comparison of Fighter Pilots and Ground Staff

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18062982 ◽

2021 ◽

Vol 18 (6) ◽

pp. 2982

Author(s):

Chao-Yin Kuo ◽

Chia-Lien Hung ◽

Hsin-Chien Chen ◽

Cheng-Ping Shih ◽

Rou-Huei Lu ◽

...

Keyword(s):

High Frequency ◽

Noise Exposure ◽

Pure Tone Audiometry ◽

Aircraft Noise ◽

Distortion Product Otoacoustic Emission ◽

Military Aircraft ◽

Cross Sectional ◽

Distortion Product ◽

Hearing Thresholds

We examined the immediate and long-term impacts of military aircraft noise exposure on noise-induced hearing loss (NIHL) in fighter pilots and ground staff. We recruited 40 pilots, 40 ground staff, and 136 age-matched controls; all participants underwent hearing tests, including conventional pure-tone audiometry (PTA) (0.25–8.0 kHz), extended high-frequency (EHF) audiometry (9.0–18.0 kHz), and distortion-product otoacoustic emission (DPOAE) as a recent reference. A subsequent hearing test immediately after flight-mission noise exposure was requested. The results revealed higher recent hearing thresholds in pilots and ground staff than in controls. Threshold shifts at many octave band frequencies were also significantly elevated in ground staff. The grouped frequency threshold was significantly elevated in the 4–8 kHz high-frequency range. After a single flight-mission noise exposure, both ground staff and pilots showed decreased signal-to-noise ratios for DPOAE (1–8 kHz), whereas only ground staff showed significantly elevated left-ear hearing thresholds at 3, 11.2, and 12.5 kHz by conventional and EHF PTA. Fighter pilots and ground staff serve in hazardous noise-exposed environments that cause hearing damage and subsequent NIHL, but ground staff may be more vulnerable. A comprehensive hearing conservation program should be implemented to protect high-risk service members, and especially ground staff, from high-intensity noise exposure.

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