scholarly journals DEVELOPMENT AND VALIDATION OF NEW FT-IR SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND CETIRIZINE HYDROCHLORIDE IN COMBINED PHARMACEUTICAL SOLID TABLET DOSAGE FORM

2019 ◽  
Vol 10 (3) ◽  
pp. 110-114
Author(s):  
Sailesh J Wadher ◽  
Bhagwan B Supekar ◽  
Shivraj S Shivpuje
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Simultaneous Estimation ◽  
Cetirizine Hydrochloride ◽  
Ft Ir ◽  
Ambroxol Hydrochloride ◽  
Development And Validation ◽  
Tablet Dosage

scholarly journals Simultaneous Estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in Pharmaceutical Tablet Dosage Form by Simultaneous Equation Spectrophotometric Method: A Quality Control Tool for Dissolution Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Deepak Sharma ◽  
Mankaran Singh ◽  
Dinesh Kumar ◽  
Gurmeet Singh
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Simultaneous Equation ◽  
Drug Formulation ◽  
Simultaneous Estimation ◽  
Validation Parameters ◽  
Quality Control Tool ◽  
Cetirizine Hydrochloride ◽  
Ambroxol Hydrochloride ◽  
Tablet Dosage

Ambroxol Hydrochloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. A simple, economical, accurate, and precise method for simultaneous estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in tablet dosage form has been developed. Simultaneous equation method based on measurement of absorbance at two wavelengths, that is, 244 nm and 230 nm, λmax of Ambroxol Hydrochloride and Cetirizine Hydrochloride in pH 6.8 phosphate buffer. Both of these drugs obeyed Beer-Lambert’s law in the concentration range of 2–18 µg/mL for Ambroxol Hydrochloride and 2–20 µg/mL for Cetirizine Hydrochloride. The high values of correlation coefficient (R) indicated good linearity of calibration curve for both the drugs. The accuracy and precision of method were determined and the method was validated statistically. Result of percentage recovery study confirms the accuracy of proposed method. As per the ICH guidelines, the method validation parameters checked were linearity, accuracy, precision, and assay of drug formulation. Based on the results obtained, it can be concluded that the proposed simultaneous equation spectrophotometric method for simultaneous estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride is rapid, economical, accurate, precise, and reproducible. Hence, the proposed method can be employed for quantitative estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride from their tablet dosage form.

scholarly journals Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Hesperidin and Diosmin in the Pharmaceutical Dosage Form

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Doddi Srilatha ◽  
Mahesh Nasare ◽  
Borra Nagasandhya ◽  
Valluri Prasad ◽  
Prakash Diwan
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Cost Effective ◽  
Simultaneous Estimation ◽  
Good Reproducibility ◽  
Pharmaceutical Dosage Form ◽  
Quality Control Tool ◽  
Development And Validation ◽  
Tablet Dosage ◽  
Control Tool

A simple, rapid, precise and highly selective spectrophotometric method was developed for simultaneous estimation of Hesperidin and Diosmin in tablet dosage form. This method, involves the measurement of absorbances of Hesperidin and Diosmin at the wavelengths of 285 nm (λmax of Hesperidin) and 268 nm (λmax, of Diosmin). The UV spectra’s of Hesperidin and Diosmin prepared in different solvents water, methanol, and acetonitrile and 0.2 N sodium hydroxide were recorded. These two drugs showed good absorbances when dissolved in 0.2 N NaOH. Hence 0.2 N NaOH was selected as the solvent for the method. Two wavelengths 285 and 268 nm were selected which are λmax of two drugs Hesperidin and Diosmin, respectively. Different concentrations of Hesperidin (5–50 μg/mL) and Diosmin (2–24 μg/mL) and a mixture of Hesperidin and Diosmin were prepared, scanned and absorbances were noted at the two wavelengths were fixed for the study. The method showed good reproducibility and recovery with % RSD less than 2. The LOD of Hesperidin and Diosmin was found to be 0.139 μg/mL and 0.048 μg/ml and LOQ of Hesperidin and Diosmin was found to be 0.42 μg/mL and 0.147 μg/mL, respectively. Thus the proposed method was found to be rapid, specific, precise, accurate and cost effective quality control tool for the routine analysis of Hesperidin and Diosmin in bulk and combined dosage form.

scholarly journals Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Metformin and Glipizide in Tablet Dosage Form

2016 ◽  
Vol 1 (02) ◽  
pp. 56-59
Author(s):  
D. Sireesha ◽  
K. Ganesh ◽  
G. Nikitha ◽  
B. Vasudha
Keyword(s):  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Dosage Form ◽  
Limit Of Detection ◽  
Simultaneous Equation ◽  
Simultaneous Estimation ◽  
Beer’S Law ◽  
Development And Validation ◽  
Tablet Dosage ◽  
Detection And Quantification

A simple, rapid and precise spectrophotometric method has been developed for simultaneous estimation of Metformin and Glipizide. The method involved estimation of Metformin and Glipizide by simultaneous equation at 272nm and 232nm respectively in their solution in water. This method was validated with respect to linearity, accuracy, precision, LOD and LOQ. Beer’s law obeyed in the concentration range of 5-25μg/ml and 20-50μg/ml for Metformin and Glipizide respectively with the correlation coefficient of above 0.99. Limit of detection and quantification values were determined to be 0.214μg/ml and 0.649μg/ml for Metformin and 0.608μg/ml and 1.854μg/ml for Glipizide respectively. Mean recovery of Metformin and Glipizide were found to be in the range of 98-102% signifies the accuracy of the method. The method was found to be precise as %RSD was less than 2.

scholarly journals Development and Validation of Dual Wavelength UV Spectrophotometric Method for simultaneous estimation of Cilnidipine and Olmesartan Medoxomil in Tablet dosage form

2014 ◽  
Vol 2 (01) ◽  
pp. 76-81
Author(s):  
Isha J. Soni ◽  
Hiral J. Panchal
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Drug Product ◽  
Olmesartan Medoxomil ◽  
Dual Wavelength ◽  
Simultaneous Estimation ◽  
Combination Drug ◽  
Absorbance Difference ◽  
Development And Validation ◽  
Tablet Dosage

A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of Cilnidipine and Olmesartan Medoxomil in their tablet dosage form. The principle for dual wavelength method is “the absorbance difference between two points on the overlain spectra is directly proportional to the concentration of the component of interest”. From the UV absorption spectrum of Cilnidipine, three wavelengths were selected, which were 282.99, 337.85 and 352.92 nm. At 352.92 nm only Cilnidipine has reasonable absorbance, so it was selected for the estimation of it from combination drug product. At these two wavelengths absorbance for Cilnidipine was found to be same i.e. absorbance difference was zero for any concentration, while for Olmesartan Medoxomil concomitantly increase in absorbance difference with increase in its concentration. So, 282.99 and 337.85 nm wavelengths were selected for the estimation of Olmesartan Medoxomil from its combination drug product. The method involved solving of an equation based on measurement of absorbances at two wavelengths 282.99 and 337.85 nm. Regression analysis of Beer’s plots showed good correlation in concentration range of 10-60 μg/ml for Cilnidipine and 20-120 μg/ml for Olmesartan Medoxomil. The suitability of this method was for quantitative determination of Cilnidipine and Olmesartan Medoxomil was proved by validation and recovery study. The proposed method was found to be simple, rapid, economical, accurate and reproducible for the routine analysis of both drugs in tablet dosage forms.

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF FAMOTIDINE, DICLOFENAC AND PARACETAMOL IN THEIR COMBINED DOSAGE FORM

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (09) ◽  
pp. 60-64
Author(s):  
P. P Desai ◽  
◽  
N. R. Patel ◽  
H. G Bhatt
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Simultaneous Equation ◽  
Simultaneous Estimation ◽  
Absorbance Measurement ◽  
Validation Parameters ◽  
Stock Solutions ◽  
Development And Validation ◽  
Tablet Dosage

Famotidine (FAM), Diclofenac (DCF) and Paracetamol (PCM) are used in combination for musculoskeletal disorders. A simple, sensitive, rapid, precise, reproducible and accurate spectrophotometric method for simultaneous determination of FAM, DCF and PCM was developed. The method was based on UV spectrophotometric determination of three drugs using simultaneous equation method. The stock solutions were prepared in methanol AR. Absorbance measurement was carried out at 288.4 nm, 281.2nm and 248.2 nm for FAM, DCF and PCM respectively. Beer Lambert law was obeyed in the concentration range of 1-30μg/mL for FAM, 2-40μg/mL for DCF and 1-20μg/mL for PCM. The results of the analysis were tested and validated for various validation parameters statistically and by recovery studies according to the International Conference on Harmonization Q2B guidelines. The utility of the developed method has been demonstrated by analysis of commercially available tablet dosage form.

scholarly journals Development and Validation of UV Spectrophotometric Method for the Estimation of Cilnidipine and Valsartan in Bulk and Pharmaceutical Formulations

2019 ◽  
Vol 12 (4) ◽  
pp. 35-42
Author(s):  
Deshmukh Madhuri D ◽  
Deshmukh Supriya D
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Low Cost ◽  
Pharmaceutical Formulations ◽  
Simultaneous Equation ◽  
Simultaneous Estimation ◽  
Coefficient Of Correlation ◽  
Development And Validation ◽  
Tablet Dosage ◽  
Complex Extraction

A simple, rapid, accurate, precise, specific and economical spectrophotometric method for simultaneous estimation of Cilnidipine and Valsartan in combined tablet dosage form has been developed. Its employs Formation and solving of simultaneous equation using two wavelengths 240.20nm and 250nm using methanol as solvent. This method obeys Beers law in the employed concentration range 2-12μg /mL and 8-40 μg /mL for Cilnidipine and Valsartan respectively. Coefficient of correlation (R2) was 0.999for Cilnidipine and 0.999 for Valsartan. This method can be adopted in routine analysis of Cilnidipine and Valsartan in bulk and tablet dosage form and it involves relatively low cost solvent and no complex extraction technique.

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