A Case Study on Giant Malignant Phyllodes Tumor of the Breast

Abstract The paper aims to introduce the case of an extensive breast malignancy – phyllodes tumor. This type of breast neoplasm is relatively rare. Indeed, it accounts for only 0.3-1% of all breast malignant tumours. In the paper, patient, disease, and treatment methods were described and evaluated. The efficacy of surgical treatment and adjuvant therapy (radiotherapy and chemotherapy) was assessed based on literature data. The authors concluded that late diagnosis of phyllodes tumor causes the necessity of mastectomy and radiotherapy and aggravates the prognosis.

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Kiss Flaps to Repair Large Skin Defect After Excision of Giant Malignant Phyllodes Tumor of the Breast: A Case Report and Literature Review

10.21203/rs.3.rs-461534/v1 ◽

2021 ◽

Author(s):

Yuwei Luo ◽

Chang Zou ◽

Jintao Hu ◽

Pan Zhao ◽

Yayuan Zhang ◽

...

Keyword(s):

Phyllodes Tumor ◽

Surgical Excision ◽

Primary Treatment ◽

Surgical Margins ◽

Skin Defect ◽

Case Presentation ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

Large Skin

Abstract Background: Malignant phyllodes tumors of the breast are fairly rare and fast-growing tumors. They do not respond to chemotherapy or hormonal therapy except in malignant phyllodes tumors. Therefore, the primary treatment for malignant phyllodes tumors is wide surgical excision. Case presentation: Herein, we report a case study which featured a 26-year-old woman presented with a giant malignant phyllodes tumor measuring 20 × 17 × 13 cm. In order to reduce the chance of local recurrence, treatment for these types of tumors usually involves extensive excision with at least 1 cm of surgical margins. The patient underwent extended lumpectomy with 1-3 cm surgical margins, which left a large skin defect of 25 × 15 cm. Repair of such a large skin defect is a challenge to breast surgeons. This is the first reported case in which a “kiss” flap was successfully used to repair the skin defect created after resection of a giant malignant phyllodes tumor.Conclusions: The kiss flap could be considered as an effective method to repair large chest wall defects after resection of giant phyllodes tumors.

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Recurrent Malignant Phyllodes Tumor of the Breast: A Rare Occurrence in a Young Nulliparous Woman

RECENT ADVANCES IN PATHOLOGY AND LABORATORY MEDICINE ◽

10.24321/2454.8642.201707 ◽

2017 ◽

Vol 03 (04) ◽

pp. 8-11

Author(s):

Sonam Sharma ◽

Keyword(s):

Phyllodes Tumor ◽

Nulliparous Woman ◽

Rare Occurrence ◽

Malignant Phyllodes Tumor

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Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Breast Care ◽

10.1159/000448236 ◽

2016 ◽

Vol 11 (4) ◽

pp. 291-294 ◽

Cited By ~ 1

Author(s):

Canan Kelten ◽

Ceren Boyaci ◽

Cem Leblebici ◽

Kemal Behzatoglu ◽

Didem C. Trabulus ◽

...

Keyword(s):

Case Report ◽

Bone Cyst ◽

Clinical Breast Examination ◽

Phyllodes Tumor ◽

Breast Cancer Diagnosis ◽

Left Breast ◽

Malignant Phyllodes Tumor ◽

Her Family ◽

Simple Mastectomy ◽

Clinical Breast

Background: Malignant phyllodes tumors of the breast are rare biphasic neoplasms. Only few cases related to pregnancy have been reported. Case Report: A 37-year-old woman presented with swelling and pain in her left breast as well as hyperemia on the breast skin, 4 weeks after labor. In her family history, her aunt and maternal cousin had had a breast cancer diagnosis. Clinical evaluation of the patient was consistent with a breast abscess. Therefore, abscess drainage and biopsy from the cavity wall were performed. However, the biopsy was diagnosed as malignant phyllodes tumor. An evaluation by ultrasonography showed a well-defined hypoechoic mass with many cystic spaces covering the entire breast tissue. Therefore, a simple mastectomy was performed. Microscopic examination revealed a high-grade malignant phyllodes tumor. Additionally, bone cyst-like areas in the form of sponge-like blood-filled non-endothelialized spaces were observed. Conclusions: Since the breasts become larger due to the physiological changes during pregnancy, any underlying breast lesions may be obscured. Therefore, clinical breast examination in the first visit of pregnancy is important.

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Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

Surgical Case Reports ◽

10.1186/s40792-021-01113-x ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Kimihisa Mizoguchi ◽

Kazuhisa Kaneshiro ◽

Makoto Kubo ◽

Yoshihiko Sadakari ◽

Yoshizo Kimura ◽

...

Keyword(s):

Rare Case ◽

Phyllodes Tumor ◽

Left Breast ◽

Lymph Node Biopsy ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Malignant Phyllodes Tumor ◽

Csf Levels ◽

Wbc Count ◽

Stimulating Factor

Abstract Background Granulocyte-colony stimulating factor (G-CSF)-producing tumors can cause leukocytosis despite an absence of infection. G-CSF-producing tumors have been reported in various organs such as the lung, esophagus, and stomach but rarely in the breast. We report a case of G-CSF-producing malignant phyllodes tumor of the breast. Case presentation An 84-year-old woman visited our hospital complaining of a lump in her left breast without fever and pain. Laboratory tests revealed elevated white blood cell (WBC) count and G-CSF levels. A malignant tumor of the breast was diagnosed by core needle biopsy. We performed a total mastectomy and sentinel lymph node biopsy. The tumor was identified as a G-CSF-producing malignant phyllodes tumor. Within 7 days after surgery, the patient’s WBC count and G-CSF level had decreased to normal levels. She is alive without recurrence 13 months after surgery. Conclusions We encountered a rare case of G-CSF-producing malignant phyllodes tumor of the breast. PET–CT revealed diffuse accumulation of FDG in the bone. Phyllodes tumors need to be differentiated from bone metastasis, lymphoma, and leukemia. We must be careful to not mistake this type of tumor for bone marrow metastasis.

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Malignant Phyllodes Tumor With Liposarcomatous Differentiation

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-421-mptwld ◽

2005 ◽

Vol 129 (3) ◽

pp. 421-422

Author(s):

Phillip A. Isotalo ◽

Ralph L. George ◽

Ross Walker ◽

Sandip K. SenGupta

Keyword(s):

Phyllodes Tumor ◽

Malignant Phyllodes Tumor

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Phyllodes Tumor Metastatic to Thyroid HürthleCell Adenoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-1233-ptmtth ◽

2002 ◽

Vol 126 (10) ◽

pp. 1233-1236

Author(s):

Tamar Giorgadze ◽

Richard M. Ward ◽

Zubair W. Baloch ◽

Virginia A. LiVolsi

Keyword(s):

Tumor Metastasis ◽

Unusual Case ◽

Cellular Proliferation ◽

Phyllodes Tumor ◽

Thyroid Tumor ◽

Cell Adenoma ◽

Malignant Phyllodes Tumor ◽

Hürthle Cell ◽

Thyroid Mass ◽

Tumor To Tumor Metastasis

Abstract We present a case of a malignant phyllodes tumor metastasizing to a Hürthle cell adenoma of the thyroid. A 55-year-old woman underwent mastectomy for a malignant phyllodes tumor. Two years later, she presented with a left thyroid mass, which was a single, circumscribed, soft, deep red-brown nodular lesion with an eccentric area of firmer consistency. Histologically, the thyroid tumor was composed of 2 distinct types of cellular proliferation. Atypical spindle cells were infiltrating between the Hürthle cell cords and follicles in a fibrosarcomatous pattern. A battery of immunohistochemical stains was applied to both the thyroid and breast tumors for comparison. Based on the histologic and immunophenotypic features of the fibrosarcomatous components of both the breast and thyroid tumors, we rendered a diagnosis of cystosarcoma phyllodes metastatic to Hürthle cell adenoma. To the best of our knowledge, this unusual case is a first report of tumor-to-tumor metastasis of a sarcoma to a primary thyroid neoplasm.

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