Effect of Orally Ebselen (SPI-1005) towards Glutathione and Malondialdehyde Blood Level and Otoacoustic Emissions Result in Soldiers with Acoustic Trauma Risk

2021 ◽  
pp. 47-62
Author(s):  
S. Sasongko ◽  
T. Boesoirie ◽  
I. Parwati ◽  
H. Sastramihardja ◽  
J. Bashirudin
Keyword(s):  
Blood Level ◽  
Otoacoustic Emissions ◽  
Acoustic Trauma

Otoacoustic Emissions and Persistent Tinnitus after Acute Acoustic Trauma

2006 ◽  
pp. 970-975 ◽  
Author(s):  
Jean-Bertrand Nottet ◽  
Annie Moulin ◽  
Nicolas Brossard ◽  
Beno??t Suc ◽  
Agn??s Job
Keyword(s):  
Otoacoustic Emissions ◽  
Acoustic Trauma ◽  
Acute Acoustic Trauma

Transient‐evoked otoacoustic emissions and high‐frequency acoustic trauma in the guinea pig

1995 ◽  
Vol 97 (5) ◽  
pp. 3012-3020 ◽  
Author(s):  
Paul Avan ◽  
Pierre Bonfils ◽  
Drystan Loth ◽  
Michel Elbez ◽  
Manuel Erminy
Keyword(s):  
Guinea Pig ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Acoustic Trauma ◽  
Transient Evoked Otoacoustic Emissions

scholarly journals Frequency tuning of the contralateral medial olivocochlear reflex in humans

2012 ◽  
Vol 108 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Wei Zhao ◽  
Sumitrajit Dhar
Keyword(s):  
Otoacoustic Emissions ◽  
Frequency Tuning ◽  
Acoustic Trauma ◽  
Fixed Frequency ◽  
Sound Perception ◽  
Spontaneous Otoacoustic Emissions ◽  
Functional Roles ◽  
Cochlear Gain ◽  
Medial Olivocochlear

Activation of the medial olivocochlear (MOC) efferents attenuates cochlear gain and reduces the amplitudes of mechanical, electrical, and neural cochlear outputs. The functional roles of the MOC efferents are not fully understood, especially in humans, despite postulations that they are involved in protection against acoustic trauma, facilitation of transient-sound perception, etc. Delineating the frequency tuning properties of the MOC efferents would provide critical evidence to support or refute these postulated functional roles. By utilizing spontaneous otoacoustic emissions (SOAEs), a cochlear measure sensitive to MOC modulation, we systematically demonstrate in humans that the contralateral MOC reflex is tuned to a fixed frequency band between 500 and 1,000 Hz independent of SOAE frequency. Our results question the role of the MOC reflex in protection against acoustic trauma or facilitation of transient-sound perception.

Loss and Recovery of Sound-Evoked Otoacoustic Emissions in Young Chicks following Acoustic Trauma

2005 ◽  
Vol 10 (4) ◽  
pp. 209-219 ◽  
Author(s):  
Ramin Ipakchi ◽  
Tim Kyin ◽  
James C. Saunders
Keyword(s):  
Otoacoustic Emissions ◽  
Acoustic Trauma ◽  
Young Chicks

Effects of acoustic trauma on acoustic enhancement of electrically evoked otoacoustic emissions

2000 ◽  
Vol 107 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Hideko Heidi Nakajima ◽  
Allyn E. Hubbard ◽  
David C. Mountain
Keyword(s):  
Otoacoustic Emissions ◽  
Acoustic Trauma

Efficacy of the Antioxidant N-acetylcysteine (NAC) in Protecting Ears Exposed to Loud Music

2006 ◽  
Vol 17 (04) ◽  
pp. 265-278 ◽  
Author(s):  
Steven Kramer ◽  
Laura Dreisbach ◽  
Jill Lockwood ◽  
Kristy Baldwin ◽  
Richard Kopke ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Acoustic Trauma ◽  
Double Blind ◽  
Distortion Product ◽  
Live Music ◽  
Before And After ◽  
Loud Music ◽  
Pure Tone Threshold

Antioxidants have been reported to be effective in reducing acoustic trauma in animal models but have not been studied in humans. In this study, the antioxidant N-acetylcysteine (NAC) was evaluated to determine if it would reduce temporary changes in auditory function as a result of exposure to loud music in humans. Pure-tone thresholds and distortion product otoacoustic emissions (DPOAEs) were collected in 31 normal-hearing participants, using a randomized, double-blind, placebo-controlled design, before and after two hours of live music in a nightclub. Using repeated measures analysis of variance, no statistically significant differences were found between participants who received NAC versus a placebo for any of the outcome measures. Across all subjects, the largest pure-tone threshold shift occurred at 4 kHz. DPOAE measures were characterized by reductions in amplitude and a trend for shorter group delay values. When the 3 and 4 kHz data were examined by imposing specific criteria of greater than 2 dB DPOAE amplitude reductions and 10 dB or greater pure-tone threshold shifts, DPOAE reductions occurred more often at 3 kHz, and pure-tone shifts occurred more often at 4 kHz.

Histological evaluation of cochlear hair cell damage from noise-induced hearing loss in chinchillas

1990 ◽  
Vol 48 (3) ◽  
pp. 332-333
Author(s):  
R.V. Harrison ◽  
R.J. Mount ◽  
P. White ◽  
N. Fukushima
Keyword(s):  
Hair Cell ◽  
Evoked Potential ◽  
Cell Damage ◽  
Acoustic Trauma ◽  
Histological Evaluation ◽  
Cell Integrity ◽  
Functional Changes ◽  
Cochlear Hair Cell ◽  
Left And Right ◽  
Contralateral Ear

In studies which attempt to define the influence of various factors on recovery of hair cell integrity after acoustic trauma, an experimental and a control ear which initially have equal degrees of damage are required. With in a group of animals receiving an identical level of acoustic trauma there is more symmetry between the ears of each individual, in respect to function, than between animals. Figure 1 illustrates this, left and right cochlear evoked potential (CAP) audiograms are shown for two chinchillas receiving identical trauma. For this reason the contralateral ear is used as control.To compliment such functional evaluations we have devised a scoring system, based on the condition of hair cell stereocilia as revealed by scanning electron microscopy, which permits total stereociliar damage to be expressed numerically. This quantification permits correlation of the degree of structural pathology with functional changes. In this paper wereport experiments to verify the symmetry of stereociliar integrity between two ears, both for normal (non-exposed) animals and chinchillas in which each ear has received identical noise trauma.

Sign in / Sign up

Export Citation Format

Share Document