scholarly journals Research on Meeting the Demand of the Population for a Group of Medicines Intended for the Treatment of Skin Diseases

2021 ◽  
pp. 64-70
Author(s):  
Maryam Magomedeminovna Radzhabova ◽  
Madina Aptievna Elgakaeva ◽  
Andrey Petrovich Kostikov ◽  
Tatiana Alekseevna Kabanova ◽  
Vitaly V. Goncharov ◽  
...  
Keyword(s):  
Liver Function ◽  
Genetic Factors ◽  
Skin Diseases ◽  
Standard Of Living ◽  
High Demand ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
The World ◽  
Abc Analysis ◽  
Pharmacy Chain

The problem of the spread of skin diseases in Russia and abroad in the last period is quite acute. Among the reasons for the development of this group of diseases, researchers determine genetic factors, poor ecology, impaired liver function, etc. In this regard, those suffering from this group of diseases are necessarily provided with qualified medical care, and pharmacy institutions form the necessary range of drugs that can improve the standard of living of patients. For this reason, we consider it necessary to analyze the level of demand for certain drugs used for the treatment of skin diseases in the pharmacy network of Belgorod, as well as factors that allow us to assess certain aspects that affect the formation of the range of these drugs in pharmacies. The purpose of the work was defined as follows: to conduct a study of meeting the demand of the population for groups of medicines intended for the treatment of skin diseases. The conducted analysis shows the following. Drugs intended for the treatment of skin diseases are in high demand (59.09%); 22.73% of drugs are in low demand, the lack of demand was observed in 18.18% of the studied group of drugs. In this paper, recommendations were formulated to optimize the assortment policy of the World of Medicines pharmacy chain in Belgorod. Since it was determined that high demand drugs such as Argosulfan, Belosalic, Avekort, Cinocap, Candiderm, Alorom, Lomaherpan, and, Nitrofungin. It is for this reason that it is necessary to increase the volume of their purchases to better meet the demand of the population for these drugs. It was also revealed that it is necessary to reduce the volume of purchases of drugs, the demand for which is reduced. It is drugs such as Daktarin, Adolen, Camadol, Ammifurin, Bramisil, Batrafen, and Hiporhamin (they came in the results of ABC-analysis to the group C). In addition, the pharmacy should promote this group of drugs to familiarize consumers with them and offer them at a reduced price, so as not to burden the turnover of medicines and not to reduce the effectiveness of the pharmacy. The paper concluded that, according to the study, the demand for medicines used in the treatment of skin diseases is quite high. At the same time, the administration of the pharmacy chain should pay more attention to the analysis of the purchased groups of medicines in this category in order to prevent overloading the pharmacy balance with drugs, the demand for which is reduced, as this negatively affects the effectiveness of the pharmacy organization. In this regard, it is advisable to conduct an ABC analysis of the assortment groups of drugs at least once a quarter, as well as take the necessary measures to promote drugs used in the treatment of skin diseases that are in insufficient demand among the population.

scholarly journals HUBUNGAN KONSUMSI ALKOHOL DENGAN GANGGUAN FUNGSI HATI PADA SUBJEK PRIA DEWASA MUDA DI KELURAHAN TATELI DAN TELING ATAS MANADO

e-CliniC ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Dicky Conreng ◽  
B. J. Waleleng ◽  
Stella Palar
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Alcohol Consumption ◽  
Liver Function ◽  
Alcoholic Liver Disease ◽  
Impaired Liver Function ◽  
The Third ◽  
Impaired Liver ◽  
Keywords Alcohol ◽  
The World

Abstract: Alcohol consumption is the third biggest risk factor as a cause of disease and disability in the world, and is the biggest risk factor in America and second biggest in Europe as the cause of disease and disability. Alcohol is a causalfactorin 60 types of diseases and injuries and a component cause in 200 others. There are many diseases that is caused by alcohol consumption, one of them causes impaired liver function, such as alcoholic liver disease. However according to the theory, not all alcoholics will have an impaired liver function, so this reasearch was done to confirm that theory. Alcoholism will be measured by the AUDIT questionnaire and the impaired liver function will be measured by the increase in the GGT enzyme. Conclusion: Not all chronic alcoholics will have impaired liver function with the same amount of alcohol consumption. Keywords: alcohol, impaired liver function, alcoholic liver disease, AUDIT, GGT.     Abstrak: Konsumsi alkohol merupakan faktor risiko terbesar ketiga di dunia sebagai penyebab penyakit dan disabilitas, dan merupakan faktor risiko terbesar pertama di Amerika serta faktor risiko terbesar kedua di Eropa sebagai penyebab penyakit dan disabilitas. Alkohol merupakan faktor penyebab dari sekitar 60 jenis penyakit dan merupakan faktor komponen dari 200 jenis penyakit lainnya. Terdapat berbagai jenis penyakit yang disebabkan oleh konsumsi alkohol, salah satunya adalah gangguan fungsi hati seperti penyakit hati alkoholik (alcoholic liver disease). Namun menurut teori tidak semua peminum alkohol akan mengalami gangguan fungsi hati, sehingga penelitian ini dilakukan untuk memastikan teori tersebut. Gangguan konsumsi alkohol akan diperiksa menggunakan kuesioner AUDIT dan gangguan fungsi hati akan diperiksa melalui peningkatan enzim GGT. Simpulan: Tidak semua peminum alkohol kronik akan mengalami gangguan fungsi hati dengan jumlah konsumsi alkohol yang sama. Kata kunci: alkohol, gangguan fungsi hati, penyakit hati alkoholik, AUDIT, GGT.

Urokinase Antigen in Plasma of Patients with Liver Cirrhosis and Hepatoma

1985 ◽  
Vol 54 (03) ◽  
pp. 617-618 ◽  
Author(s):  
J C Kirchheimer ◽  
K Huber ◽  
P Polterauer ◽  
B R Binder
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Liver Function ◽  
Matched Control ◽  
Malignant Growth ◽  
Control Groups ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
Specific Medication ◽  
History Of

SummaryPlasma urokinase antigen levels were studied in 78 patients suffering from liver diseases. Blood was drawn before any specific medication was initiated. Impairment of liver function was comparable in all patients. In both groups of cirrhotic liver disease (alcoholic and non-alcoholic), normal levels of plasma urokinase antigen were found as compared to age-matched control groups. In both groups of patients with hepatomas (with or without a history of liver cirrhosis), however, significantly increased plasma urokinase antigen levels could be determined. These data indicate that an increase in plasma urokinase antigen might rather relate to malignant growth in liver disease than to impaired liver function.

scholarly journals A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD

2015 ◽  
pp. 93 ◽  
Author(s):  
Rajshekhar Chakraborty ◽  
Shiva Kumar Reddy Mukkamalla ◽  
Garfield Gutzmore ◽  
Hon Cheung Chan
Keyword(s):  
Liver Function ◽  
Impaired Liver Function ◽  
Impaired Liver

Imatinib mesylate therapy in patients with gastrointestinal stromal tumors and impaired liver function

2002 ◽  
Vol 13 (8) ◽  
pp. 847-849 ◽  
Author(s):  
Sebastian Bauer ◽  
Volker Hagen ◽  
Hermann J Pielken ◽  
Peter Bojko ◽  
Siegfried Seeber ◽  
...  
Keyword(s):  
Liver Function ◽  
Imatinib Mesylate ◽  
Gastrointestinal Stromal Tumors ◽  
Impaired Liver Function ◽  
Stromal Tumors ◽  
Impaired Liver

Abstract 15268: Development of a Reliable Means of Assessment of Liver Function After the Fontan Operation: Dual Cholate Clearance Assay

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Yuli Y Kim ◽  
Greg Everson ◽  
Steve Helmke ◽  
Jessica Carducci ◽  
Andrew C Glatz ◽  
...  
Keyword(s):  
Liver Function ◽  
Fontan Operation ◽  
Hepatic Clearance ◽  
Severity Index ◽  
Hepatic Function ◽  
Shunt Fraction ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
Fontan Patients ◽  
Normal Controls

Introduction: Currently there is no biomarker or test to accurately measure liver function in Fontan-associated liver disease. The dual cholate test (HepQuant SHUNT) is a noninvasive, flow-dependent assay measuring hepatic clearance of a bile acid, cholate, and may serve as a useful measure of liver function in the Fontan. We aim to measure cholate clearance in a cohort of Fontan patients and compare to normal controls. Methods: Single center, prospective pilot study of Fontan patients ≥ 18 years. Hepatic clearance of orally administered d4-cholate and intravenously administered 13C-cholate were measured in peripheral venous samples after 5, 20, 45, 60, and 90 minutes. Portal hepatic filtration rate (HFR), systemic HFR, shunt fraction (systemic HFR/portal HFR), and disease severity index (DSI) were calculated. Decline in HFRs and increase in shunt fraction or DSI is indicative of impaired liver function. Two-sided t-tests were used to compare values between Fontans and controls. Results: Twelve Fontan patients were enrolled (33% female, median age 29.9 [range 23.6 - 41.0] years). Median total bilirubin was 0.8 (range 0.3-2.1) mg/dL, AST 30.5 (range 16-55) U/L, ALT 32 (range 11-53) U/L, alkaline phosphatase 87 (range 42-191) U/L and platelets 177 (range 130-428) 10 3 /μL. Mean cardiac index was 3.0 ± 0.5 L/min/m 2 . Cholate clearance was lower in Fontans compared to controls (Figure). Mean portal HFR (mL/min/kg) in Fontans was lower than controls (15.1 ± 10.9 vs 29.1 ± 9.0; p<0.001) as well as systemic HFR (3.7 ± 1.3 vs 6.5 ± 1.5; p<0.001) whereas shunt fraction (%) was not (29.2 ± 11.4 vs 24.1 ± 7.5; p=NS). DSI was higher in Fontans compared to controls (19.4 ± 6.1 vs 9.2 ± 3.4; p<0.001). Conclusions: Fontan patients demonstrate reduced hepatic function compared to normal controls but there is considerable variability. Future studies using the dual cholate test will examine the relationship between liver and cardiac function, as well as risk of adverse clinical outcome, in the Fontan.

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