A Review on Acotiamide

Functional dyspepsia (FD) is mainly treated by drugs like H2 receptors antagonists, Proton pump inhibitors, prokinetics. A novel prokinetic drug to treat FD with 2 subtypes: Epigastric pain syndrome (EPS) & postprandial distress syndrome (PDS), has been introduced recently by the approval of Acotiamide, the first in class, muscarinic receptor antagonist & cholinesterase inhibitor. It has shown improvement in gastric motility in rodents & dogs and reduced PDS symptoms in patients in Double- blinded multicentric study.

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Overlap Between Postprandial Distress Syndrome and Epigastric Pain Syndrome in The DIAMOND Study

The American Journal of Gastroenterology ◽

10.1038/ajg.2013.295 ◽

2013 ◽

Vol 108 (11) ◽

pp. 1808-1810 ◽

Cited By ~ 1

Author(s):

Jan Tack ◽

Florencia Carbone

Keyword(s):

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome

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The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia

The Journal of Medical Investigation ◽

10.2152/jmi.63.230 ◽

2016 ◽

Vol 63 (3.4) ◽

pp. 230-235 ◽

Cited By ~ 11

Author(s):

Satoshi Shinozaki ◽

Hiroyuki Osawa ◽

Hirotsugu Sakamoto ◽

Yoshikazu Hayashi ◽

Alan Kawarai Lefor ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome

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Prevalence, risk factors, and ethnic characteristics of uninvestigated dyspepsia

Russian Medical Inquiry ◽

10.32364/2587-6821-2020-4-5-263-267 ◽

2020 ◽

Vol 4 (5) ◽

pp. 263-267

Author(s):

V.V. Tsukanov ◽

◽

A.V. Vasyutin ◽

Yu.L. Tonkikh ◽

◽

...

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Rural Areas ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Endoscopic Examination ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome ◽

Rome Iv

Background: in our country, studies on the prevalence of dyspepsia performed using the Rome IV criteria are rare, which makes it difficult to objectively compare Russian and international data, including ethnic characteristics. Aim: to study the prevalence and risk factors of uninvestigated dyspepsia in indigenous and foreign residents in rural areas of the Republic of Khakassia. Patients and Methods: continuous epidemiological screening (coverage 93.4%) of dyspepsia was performed in the villages Matur, Anchul, Verchnii Kurlugash, Nizhnie Siry, Bolshoy Bor, Bolshaya Seya, Verkhnyaya Seya, Inchul, Verkhnii Tashtyp of the Tashtyp district. A total of 2,080 newly-arrived residents (Caucasians, 911 males, average age 43.6 years) and 2,117 indigenous residents (Khakas, 978 males, average age 42.9 years) were surveyed. Dyspepsia was studied in accordance with the recommendations of the Rome IV criteria. Epigastric pain syndrome and postprandial distress syndrome were distinguished. Due to the fact that endoscopic examination of patients was not used, dyspepsia was considered as uninvestigated dyspepsia. The presence of Helicobacter pylori was determined serologically in 566 Caucasians and 533 Khakas. The results of clinical examination and interview (social status, complaints, medical history) were recorded in the standard questionnaires. Results: uninvestigated dyspepsia was diagnosed in 24.6% of Caucasians and 19.2% of Khakas (p<0.001). Gender did not affect the prevalence of dyspepsia in Khakas. Among Caucasians, there was a tendency to more common detection of dyspepsia in women. The pain variant of dyspepsia prevailed in men in both populations. The incidence of postprandial distress syndrome among Caucasians was significantly higher in women. Other risk factors for dyspepsia in both populations were the following: age older than 50, Helicobacter pylori infection, smoking 20 or more cigarettes per day for more than 10 years, history of gallbladder pathology, acute viral hepatitis and helminthiasis. Conclusion: the data obtained allow to consider the influence of ethnicity on the prevalence of uninvestigated dyspepsia, including depending on gender identity. KEYWORDS: uninvestigated dyspepsia, ethnic characteristics, Helicobacter pylori, prevalence, risk factors. FOR CITATION: Tsukanov V.V., Vasyutin A.V., Tonkikh Yu.L. Prevalence, risk factors, and ethnic characteristics of uninvestigated dyspepsia. Russian Medical Inquiry. 2020;4(5):264–267. DOI: 10.32364/2587–6821–2020–4-5-263-267.

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Su2074 Gastrointestinal (GI) Symptoms Induced by Spicy, Sour, and Fatty Food Ingestion in Functional Dyspepsia (FD): A Difference Between Epigastric Pain Syndrome (EPS) and Postprandial Distress Syndrome (PDS)

Gastroenterology ◽

10.1016/s0016-5085(13)62036-3 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-549-S-550 ◽

Cited By ~ 1

Author(s):

Tanisa Patcharatrakul ◽

Prima Singhagowinta ◽

Pinit Kullavanijaya ◽

Sutep Gonlachanvit

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Food Ingestion ◽

Postprandial Distress Syndrome ◽

Gi Symptoms ◽

Epigastric Pain Syndrome ◽

Fatty Food

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Evaluation of main functional dyspepsia symptoms after probiotic administration in patients receiving conventional pharmacological therapies

Journal of International Medical Research ◽

10.1177/0300060520982657 ◽

2021 ◽

Vol 49 (1) ◽

pp. 030006052098265

Author(s):

Lorenzo Drago ◽

Gabriele Meroni ◽

Dario Pistone ◽

Luigi Pasquale ◽

Giuseppe Milazzo ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Current Data ◽

Lactobacillus Delbrueckii ◽

End Of Treatment ◽

Epigastric Pain Syndrome ◽

Dyspeptic Symptoms ◽

Lactobacillus Delbrueckii Subsp

Objective Postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) are the two main forms of functional dyspepsia (FD). Probiotics are a promising therapy for FD, but current data remains heterogeneous. This work aims to evaluate a probiotic combination of Lacticaseibacillus rhamnosus LR04 (DSM 16605), Lactiplantibacillus pentosus LPS01 (DSM 21980), Lactiplantibacillus plantarum LP01 (LMG P-21021), and Lactobacillus delbrueckii subsp. delbruekii LDD01 (DMS 22106), alone or together with other pharmacological therapies, for clinical improvement of symptoms associated with FD. Methods Patients with FD were enrolled and divided into two groups: PDS and EPS. Probiotic alone or combined with prokinetics, antacids, or proton-pump-inhibitors were administered for 30 days. A progressive-score scale was used to evaluate symptoms in all patients at the beginning of the trial and at 15 days after the end of treatment. Results A cohort of 2676 patients were enrolled (1 357 with PDS; 1 319 with EPS). All patients showed significant improvements in dyspeptic symptoms following treatment. In patients with PDS, probiotic alone resulted in the lowest prevalence of symptoms following treatment, while patients with EPS showed no clear between-treatment differences. Conclusions Dyspeptic symptoms were reduced following treatment in all patients.

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Functional Dyspepsia: Subtypes, Risk Factors, and Overlap with Irritable Bowel Syndrome in a Population of African Patients

Gastroenterology Research and Practice ◽

10.1155/2012/562393 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 12

Author(s):

Sylvester Chuks Nwokediuko ◽

Uchenna Ijoma ◽

Olive Obienu

Keyword(s):

Risk Factors ◽

Irritable Bowel Syndrome ◽

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome ◽

Irritable Bowel ◽

African Patients

Background. Functional dyspepsia is the prototype functional gastrointestinal disorder. This study was designed to determine its prevalence, subtypes, and risk factors associated with the subtypes.Method. Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria.Results. Of 192 patients who had functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes accounted for 79.2%, 62.5%, and 50%, respectively. Multivariate analysis of the risk factors showed that independent predictors of postprandial distress syndrome were alcohol and irritable bowel syndrome while irritable bowel syndrome was independent predictor of epigastric pain syndrome. Alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs were independent predictors of cooccurrence of postprandial distress syndrome and epigastric pain syndrome.Conclusion. Functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients. Regarding symptomatology, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes account for 79.2%, 62.5%, and 50%, respectively. Risk factors for functional dyspepsia are irritable bowel syndrome, alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs.

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