scholarly journals Palliative surgical treatment for liver metastases arising from breast cancer

2020 ◽  
Author(s):  
Katsuhisa Enomoto
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Obstructive Jaundice ◽  
Liver Metastases ◽  
Intrahepatic Bile Duct ◽  
Left Breast ◽  
Biliary Stent ◽  
Biliary Stenting ◽  
Multiple Liver Metastases

Introduction: Patients with liver metastases arising from breast cancer presenting with jaundice have poor prognoses; most patients are not treated aggressively. However, we report an improvement in the quality of life (QOL) of the patient by inserting a biliary stent as palliative surgical treatment.Case presentation: The patient was a 63-year-old woman. She had left breast cancer and had undergone total mastectomy and axillar lymph node dissection (Bt+Ax) approximately 20 years ago. Thereafter, chemotherapy and hormonal therapy were continued for approximately 5 years. Sixteen years after the surgery, the patient presented with hepatic failure; furthermore, total bilirubin (T-Bil) levels had increased to 5.5 mg/dl. Imaging revealed multiple liver metastases and dilatation of the intrahepatic bile duct. A biliary stent was placed, and treatment for obstructive jaundice was administered. After 3 months, the patient was able to maintain QOL without any increase in T-Bil levels.Conclusion: Palliative surgical treatment via biliary stenting for the onset of obstructive jaundice due to liver metastases arising from breast cancer can be useful for maintaining patient QOL.

scholarly journals Efficacy of Combined Regional Inductive Moderate Hyperthermia and Chemotherapy in Patients With Multiple Liver Metastases From Breast Cancer

2018 ◽  
Vol 17 ◽  
pp. 153303381880600 ◽  
Author(s):  
Mykhailo Yu Klimanov ◽  
Liubov A. Syvak ◽  
Valerii E. Orel ◽  
G. V. Lavryk ◽  
Tetiana Ye Tarasenko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Metastases ◽  
Multiple Liver Metastases

scholarly journals A Case of Multiple Liver Metastases after Surgery in Elderly HER2-Positive Breast Cancer in Which Anastrozole + Trastuzumab Was Ineffective but T-DM1 Was Effective

2021 ◽  
pp. 1632-1637
Author(s):  
Tomohiro Shidahara ◽  
Shozo Ohsumi ◽  
Yuichiro Miyoshi ◽  
Mina Takahashi ◽  
Seiki Takashima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Metastases ◽  
Growth Factor Receptor ◽  
Complete Response ◽  
Lymph Node Biopsy ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Pathological Result ◽  
Multiple Liver Metastases ◽  
Positive Breast Cancer

Chemotherapy is often difficult to treat human epidermal growth factor receptor 2 (HER2)-positive metastatic recurrent breast cancer in the elderly, and no standard treatment has been established at this point. We experienced a case in which trastuzumab (Tmab) + anastrozole (ANA) was ineffective (progressive disease; PD) in elderly HER2-positive breast cancer with postoperative multiple liver metastases, but T-DM1 was significantly effective (complete response; CR), and treatment could be continued safely. An 82-year-old woman was referred to our department with a right breast mass. A close examination revealed right breast cancer cT1bN0M0 cStage I, and total mastectomy and sentinel lymph node biopsy were performed. The postoperative pathological result was pT1bN0M0 pStage I (luminal HER2 type). The patient was elderly and had no adjuvant treatment after the operation. Approximately 2 years after the operation, multiple liver metastases were observed, and treatment with ANA and Tmab was started. Four months later, MRI showed that the number of multiple liver metastases increased. The patient was diagnosed with PD, and the anti-HER2 drug was changed from trastuzumab to trastuzumab emtansine (T-DM1). The dose was reduced due to vomiting (grade 3). Two months later, MRI showed that the multiple liver metastases shrank and became obscure after 5 months. After that, T-DM1 was continued, and the disease did not worsen. In elderly people with difficulty in administering chemotherapy, T-DM1 may have a safe and sufficient therapeutic effect by adjusting the dose and managing side effects appropriately.

scholarly journals A CASE OF MULTIPLE LIVER METASTASES AFTER SURGERY FOR BREAST CANCER WITH CHURG-STRAUSS SYNDROME

2004 ◽  
Vol 65 (3) ◽  
pp. 636-641
Author(s):  
Toukichi GEN ◽  
Eiichi YABATA ◽  
Seitaku HAYASHI ◽  
Katsunori AMI ◽  
Hiroyuki OKAMOTO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Metastases ◽  
Churg Strauss Syndrome ◽  
Strauss Syndrome ◽  
Multiple Liver Metastases ◽  
Churg Strauss

scholarly journals Perioperative Tumour Marker Levels as Prognostic Factors for Surgical Treatment of Breast Cancer Liver Metastases

2018 ◽  
Vol 38 (6) ◽  
pp. 3647-3652
Author(s):  
VLADISLAV TRESKA ◽  
ONDREJ TOPOLCAN ◽  
VERA ZOUBKOVA ◽  
INKA TRESKOVA ◽  
ANDREA NARSANSKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Surgical Treatment ◽  
Liver Metastases ◽  
Tumour Marker ◽  
Breast Cancer Liver Metastases

303 POSTER Surgical treatment of liver metastases due to breast cancer

2006 ◽  
Vol 32 ◽  
pp. S91
Author(s):  
S. Nikolic ◽  
M. Inic ◽  
M. Kocic ◽  
B. Marjanovic ◽  
A. Martinovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Liver Metastases

scholarly journals Low-intensity low-frequency magnetotherapy in the early postoperative period in patients with breast cancer

2020 ◽  
Vol 17 (5) ◽  
pp. 233-240
Author(s):  
Inna S. Evstigneeva ◽  
Marina Yu. Gerasimenko
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Upper Limb ◽  
Low Frequency ◽  
Pain Syndrome ◽  
Early Postoperative Period ◽  
Advanced Technique ◽  
Low Intensity ◽  
Extended Technique

Background. Rehabilitation of patients after radical treatment of breast cancer is especially relevant due to the fact that successes in diagnostics and treatment of this disease in recent years have led to an increase in the life expectancy of female patients. Aim. to compare the efficiency of various methods of low-frequency low-intensity magnetotherapy in patients operated on for breast cancer, in the early terms (24 days) after surgery. Methods. Objective and instrumental examination was performed in 78 patients after radical surgical treatment of breast cancer in the early stages (24 days) after surgery. All patients received a course of low-frequency low-intensity magnetotherapy. Results. When applying the extended technique (the effect on the segmental-reflex region and upper limb from the side of the surgery), patients noted an improvement in the quality of life, a decrease in swelling of the upper limb, and a decrease in pain syndrome. A decrease in the number of postoperative complications and the duration of lymphorrhea was noted. Conclusion. Thus, the use of various methods of low-frequency low-intensity magnetotherapy is advisable to use in the early terms (24 days) after surgical treatment, however, the use of the advanced technique provides high function capabilities and enables to get a more pronounced and lasting clinical result.

scholarly journals HER2-Positive Conversion in a Metastatic Liver Focus in Late Recurrent Breast Cancer

2019 ◽  
Vol 12 (2) ◽  
pp. 473-479 ◽  
Author(s):  
Miyuki Kitahara ◽  
Yasuo Hozumi ◽  
Ayaka Nakamura ◽  
Kana Tachi ◽  
Hitoaki Saitoh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bile Duct ◽  
Intrahepatic Bile Duct ◽  
Left Breast ◽  
Histopathological Diagnosis ◽  
Hepatic Tumors ◽  
Her2 Positive ◽  
Er Positive ◽  
Poorly Differentiated ◽  
Duct Cancer

Late recurrence of estrogen receptor (ER) positive breast cancer is common. When tissues from a recurrent or metastatic focus are available, re-evaluation of ER, progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) status is recommended for treatment selection. This case report describes a 59-year-old woman who underwent surgery for left breast cancer, with a histopathological diagnosis of invasive ductal carcinoma (pathological stage T2N1aM0 Stage IIB, ER positive, PgR positive and HER2 negative). A health check-up 16 years after surgery revealed multiple hepatic mass lesions, and the patient was referred to our hospital for tests. Based on computed tomography, intrahepatic bile duct cancer or metastatic hepatic tumors were suspected, and a liver biopsy was performed. The histopathological diagnosis was a poorly differentiated adenocarcinoma (ER negative, PgR negative and HER2 positive), and the distinction from poorly differentiated intrahepatic bile duct cancer was difficult. Fluorodeoxyglucose (FDG)-positron emission tomography revealed FDG accumulation in the patient’s bones and soft tissues, in addition to the hepatic tumors. The patterns and finding of metastasis were compatible with breast cancer recurrence, and the patient was diagnosed with postoperative recurrence of left breast cancer. Pertuzumab, trastuzumab, and docetaxel were started, and the therapeutic effect was assessed as a partial response. It was evident that in this case, the expression of hormone receptors and HER2 differed between the primary focus and the recurrence foci, and this contributed to the treatment strategy. Whenever possible, a biopsy should be performed for lesions that are suspected to be distal metastases.

Comparison of the quality of life of women with breast cancer after mastectomy and after breast-conserving therapy: prospective observational study

2017 ◽  
Vol 86 (3) ◽  
pp. 220
Author(s):  
Iwona Głowacka-Mrotek ◽  
Magdalena Sowa ◽  
Krystyna Nowacka ◽  
Tomasz Nowikiewicz ◽  
Wojciech Hagner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Surgical Treatment ◽  
Cancer Patients ◽  
Developed Countries ◽  
Breast Conserving Therapy ◽  
Life Assessment ◽  
Breast Cancer Patients ◽  
Eortc Qlq

Introduction. Breast cancer is the most common malignancy in women in developed countries. Treatment of this disease affects the quality of life of patients. Quality of life is an ambiguous concept, which refers to the state of health, severity of symptoms, and implemented treatment. It is also linked to meeting individual needs of each person.Aim. The aim of the study was to assess the quality of life of breast cancer patients according to the type of previous surgery.Material and Methods. The study was conducted prospectively. The study population included 101 women with breast cancer after surgical treatment in the period from October 2012 to October 2014 (51 cases after mastectomy, the remaining ones after breast‑conserving therapy). Standard questionnaires EORTC QLQ‑C30 and QLQ‑BR23 were used to assess the quality of life (assessment on the day of admission to the department, two months and one year after surgery).Results. The analysis of QLQ‑C30 revealed no statistically significant differences between the compared groups of patients. Regarding the analysis of QLQ‑BR23, statistically significant differences related to the assessment of the patient's own body and life perspectives, evaluation of sexual feelings and social roles (they were not found in the evaluation of sexual functioning, undesirable effects of treatment or symptoms associated with the affected breast).Conclusions. Regardless of the type of surgery performed, breast cancer patients require similar psychological actions supporting their possibility of adapting to the new situation and dealing with negative effects of surgical treatment.

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