Abstract
Background: The present study aims to study the Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous extracts of Schleichera oleosa.Result: The amount of RBC was found to be 9.6±0.057106/mm3, 9.7±0.0125, 106/ 9.5±0.003, 106/mm3 9.5±0.012 106/mm3 and 9.5±0.023 106/mm3. The amount of WBC was found to be 13.5±0.058 103/mm3,13.6±0.0113 103/mm3,13.7±0.021 103/mm3, 9.5±0.012 103/mm3 and 9.5±0.023 103/mm3. Platelets, 396±0.577 103/mm3, 395±0.03 103/mm3 , 397±0.042103/mm3 , 398±0.020103/mm3, and 397±0.011103/mm3 for controlled group, low dose of methanolic extract, high dose of methanolic extract, low dose of aqueous extract and high dose of aqueous extract respectively. The packed cell volume, haemoglobin, mean corpuscular volume, mean corpuscular haemoglobin, corpuscular haemoglobin concentration and amount of neutrophils, Eosinophils, Lymphocytes, Basophils and Monocytes were measured and no significant change was noticed. The amount of testosterone showed significant increase from 0.75± 0.024 pg/ mL (control) 2.96± 0.088 pg/ mL, 3.9± 0.14pg / mL, 1.85± 0.076 pg/ mL and 2.85± 0.074 pg/ mL.Conclusions: The study suggests that the prolonged treatment of Wistar rats with both low dose and high dose of methanolic as well as the aqueous extract of Schleichera oleosa is not toxic and they increased the amount of testosterone in the blood which is indicative of their testosterone enhancement.
Effects of Oral Administration of Aqueous Extract of Hibiscus sabdariffa on Some Haematological Parameters of Wistar Albino Rats
