Longer period of oral administration of aspartame on cytokine response in Wistar albino rats

2015 ◽  
Vol 62 (3) ◽  
pp. 114-122 ◽  
Author(s):  
Arbind Kumar Choudhary ◽  
Rathinasamy Sheela Devi
Keyword(s):  
Oral Administration ◽  
Cytokine Response ◽  
Albino Rats ◽  
Wistar Albino Rats

Evaluation of Toxicity and Antidiabetic Activity of Ethanolic Extract of Flowers of Moringa Oleifera Against Dexamethasone Induced Hyperglycemia in Albino WistarRats

2020 ◽  
Vol 2 (29) ◽  
pp. 72-83
Author(s):  
Sourabh Jain Neha Jain
Keyword(s):  
Insulin Resistance ◽  
Oral Administration ◽  
Moringa Oleifera ◽  
Ethanolic Extract ◽  
Serum Glucose ◽  
The Body ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Antidiabetic Effect ◽  
Wistar Albino Rats

Abstract-Diabetes is a defect in the ability of the body to convert glucose (sugar) to energy. Glucose is the main source of energy in our body. When food is digested it is metabolized into fats, proteins, or carbohydrates. Glucose is then transferred to the blood and is used by the cells for energy production. To investigate the antidiabetic effect ethanolic extracts of flowers of Moringa oleifera against dexamethasone induced insulin resistance in wistar albino rats. To study the antidiabetic effect, flowers ofMoringaoleiferawerecollectedandauthenticated, extracted and investigated for acute toxicity and dexamethasone induced hyperglcemia. The animals treated with EEMOF at a dose of 100mg/kg and 200mg/kg prevented the development ofhyperglycemia,hypercholesteremiaandhypertriglyceridemia in dexamethasone induced insulin resistance models. Oral administration of Moringa Oleifera 100mg/kg and 200mg/kg reduces serum glucose, triglyceride, total cholesterols and LDLconcentration and improve the concentration of HDLin dexamethasone administered rats. The lignin Moringa Oleifera showed significant anti-diabetic effect in rats after oral administration. The present study demonstrated that Moringa Oleifera could be useful in Management of diabetes associated with abnormalities in lipid profiles. Further study need to isolate, identify the active compounds and find out thepossiblemechanismofactions.

scholarly journals Effect of Oral Administration of Ibuprofen on Prothrombin Time, Activated Partial Thromboplastin and Platelet Count in Wistar Albino Rats

2020 ◽  
pp. 45-50
Author(s):  
Jonathan Esima ◽  
Abraham Zorte ◽  
O. Onwuli, Donatus ◽  
Waribo, Helen Anthony
Keyword(s):  
Platelet Count ◽  
Oral Administration ◽  
Prothrombin Time ◽  
Chronic Exposure ◽  
Control Group ◽  
Albino Rats ◽  
Exposure Group ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Acute And Chronic Exposure

Aim: Ibuprofen is analgesic, antipyretic and anti-inflammatory drug, which is widely used as a cheap over- the counter drug (OTC); however, this drug accompanies anti coagulation/anti platelets effects which sometimes might illicit adverse effects. In this study, we investigated effect of ibuprofen on prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelet count using wistar albino rats. Methods: A total of 21 rats grouped into 3(control, acute and chronic exposure groups, with all consisting of 7 rats each) was used. The acute and chronic exposure group were given 0.7 mg of ibuprofen orally for 1 and 21 days, respectively. Blood sample was collected via cardiac puncture then analyzed. Results: PT was significantly higher in both group 2 and 3 (acute and chronic exposure, respectively) than that of the control. Acute exposure group showed the highest PT rise. A PTT was not significantly different between group 2 and 3 versus the control group. Platelet count was significantly lower in both group 2 and 3than that in the control group (p<0.05). Group 3 (chronic exposure) showed the lowest platelet count. Conclusion: Oral administration of ibuprofen affected coagulation parameters and a longer exposure reduce platelets count. A strictly prescription for this drug may be needed to prevent its indiscriminate use.

scholarly journals Effectiveness of oral administration of peppermint and coriander extracts on cognition in Scopolamine induced rat model of amnesia

2020 ◽  
Vol 11 (3) ◽  
pp. 4222-4226
Author(s):  
Jasira Sirajudheen ◽  
Sai Sailesh Kumar Goothy ◽  
Mukkadan J K
Keyword(s):  
Oral Administration ◽  
Rat Model ◽  
Positive Impact ◽  
Neurological Diseases ◽  
Control Group ◽  
Albino Rats ◽  
Study Results ◽  
Peppermint Extract ◽  
Neuroprotective Actions ◽  
Wistar Albino Rats

Herbs and spices have been shown to be very effective in the management of the neurological disorders. They have neuroprotective actions that prevent the deterioration of the memory and other cognitive functions in the neurological diseases. Peppermint (menthe×piperita, also known as M. balsamea wild) is a hybrid mint, a cross between water mint and spearmint. Peppermint consists of several medicinal components and research was testified safety of consumption of the peppermint. The study compared the memory-boosting and regaining effects of oral administration of peppermint and coriander extracts. 36 male and female Wistar albino rats were assigned into three groups randomly that is control, coriander and peppermint groups, respectively. A control group (n=6) received neither peppermint nor coriander administered (milk was administered). Peppermint group (n=6) received peppermint extract. Coriander group (n=6) received coriander extract. Amnesia rat model was prepared by the administration of as intraperitoneal injection of scopolamine. The R-maze and T-maze tasks was conducted as mentioned in the literature. Mean trials of acquisition is significantly less (P<0.01) in the peppermint group. The number of mean trials of retention is significantly less (P<0.01) in the peppermint group. The mean trials for retention of the coriander group is significantly (P<0.05) less than the peppermint group. The study results support a positive impact of coriander and peppermint on cognition. The study recommends further detailed studies to support the administration of these extracts in the management of neurological diseases that deteriorates cognition.

scholarly journals A Comparative Study on Effect of Oral Administration of Turmeric and Nutmeg on Memory Boosting and Regaining in Wistar Albino Rats

2013 ◽  
Vol 1 (3) ◽  
pp. 46-52 ◽  
Author(s):  
SS Kumar ◽  
G Jissa ◽  
PV Setty ◽  
JK Mukkadan
Keyword(s):  
Oral Administration ◽  
Animal Studies ◽  
Oral Intake ◽  
Control Group ◽  
Albino Rats ◽  
Diabetes Research ◽  
Physiological Measures ◽  
Medical Sciences ◽  
Turmeric Extract ◽  
Wistar Albino Rats

BACKGROUND AND OBJECTIVES: Although a few drugs are available today for the management of Alzheimer's disease (AD) and many plants and their extracts are extensively employed in animal studies and AD patients, yet no substantial drug or plant extract is able to reverse the AD symptoms adequately. It is tangible that there has been augmenting need for such therapeutic intervention. The present study was undertaken with an objective to compare the memory boosting and regaining effects of oral administration of nutmeg and turmeric which are used commonly as spice in various dishes, as components of teas and soft drinks. MATERIAL AND METHODS: A total of 24 male and female wistar albino rats were used for this study. They were randomly assigned into three groups with 8 rats in each group. The influence of oral intake of nutmeg and turmeric extract on behavioral task performance was studied by using T-maze and radial arm maze and physiological measures relative to a milk control group was investigated. RESULTS: We have observed significant memory boosting and memory regaining effects of nutmeg when administered orally when compared with control group..However, nutmeg is having strong memory regaining effect than turmeric. CONCLUSION: We conclude that nutmeg is having strong memory regaining effect than turmeric. However further pharmacological and biochemical investigations will clearly elucidate the mechanism of action and helpful in projecting these plant extracts as a therapeutic target in diabetes research. DOI: http://dx.doi.org/10.3126/jucms.v1i3.8765   Journal of Universal College of Medical Sciences Vol.1(3) 2013: 46-52

scholarly journals ORAL ADMINISTRATION OF NUTMEG ON MEMORY BOOSTING AND REGAINING IN WISTAR ALBINO RATS

2014 ◽  
Vol 3 (1) ◽  
pp. 3 ◽  
Author(s):  
G Jissa ◽  
K Sai-Sailesh ◽  
J Mukkadan
Keyword(s):  
Oral Administration ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals A study on effect of oral administration of cardamom on memory boosting and regaining in wistar albino rats

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Prabha V Setty ◽  
Kumar Sai Sailesh ◽  
Neethu Neethu ◽  
Mukkadan J.K
Keyword(s):  
Oral Administration ◽  
Cholinesterase Activity ◽  
Memory Performance ◽  
Oral Intake ◽  
Control Group ◽  
Albino Rats ◽  
Physiological Measures ◽  
Acetyl Cholinesterase ◽  
Oral Consumption ◽  
Wistar Albino Rats

This study provides further evidence for improvement of memory by oral consumption of cardamom. The present study was undertaken with an objective to study the effects of oral administration of cardamom on memory boosting and regaining. Here we investigate the influence of oral intake of cardamom on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. We have observed significant memory boosting and memory regaining effects of cardamom when administered orally. This effect may be due to facilitation of acetylcholine activity by decreasing acetyl cholinesterase activity of cardamom. Hence we recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following cardamom consumption

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