scholarly journals Anti-breast carcinoma effects of green synthesized nickel nanoparticles from Alhagi ‎sparsifolia leaf aqueous extract: A pre-clinical trial study ‎

2022 ◽  
Author(s):  
Qingquan Ren ◽  
Samaneh Goorani ◽  
Behnam Mahdavi ◽  
Khodabakhsh Rashidi ◽  
Mohammad Mahdi Zangeneh
Keyword(s):  
Breast Cancer ◽  
Aqueous Extract ◽  
Nickel Nanoparticles ◽  
Lobular Carcinoma ◽  
Metastatic Carcinoma ◽  
Human Breast ◽  
Carcinoma Of The Breast ◽  
Alhagi Sparsifolia ◽  
Leaf Aqueous Extract ◽  
Inflammatory Carcinoma

IntroductionMany nanoparticles have pharmacological and biochemical properties, including antioxidant and anti-‎inflammatory properties, which appear to be involved in anticarcinogenic and antimutagenic activities. In the recent study, nickel nanoparticles were green-synthesized using the Alhagi sparsifolia leaf aqueous ‎extract. ‎Material and methodsThe synthesized Ni nanoparticles‎ were characterized by analytical techniques including SEM, UV-Vis., and FT-‎IR. The nanoparticles were formed in a spherical shape in the average size of 16.19 nm. ‎ResultsIn the antioxidant test, the IC50 of Ni nanoparticles‎ and BHT against DPPH free radicals were 316 and 231 ‎‎µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with Ni ‎nanoparticles‎ were assessed by MTT assay for 48h about the cytotoxicity and anti-human breast cancer ‎properties on normal (HUVEC) and breast cancer cell lines i.e. lobular carcinoma of breast (UACC-3133), ‎inflammatory carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453). The viability of ‎malignant breast cell line reduced dose-dependently in the presence of Ni nanoparticles‎. The IC50 of Ni ‎nanoparticles‎ were 477, 548, and 605 µg/mL against lobular carcinoma of breast (UACC-3133), inflammatory ‎carcinoma of the breast (UACC-732), and metastatic carcinoma (MDA-MB-453) cell lines, respectively. ‎ConclusionsAfter clinical study, nickel nanoparticles containing Alhagi sparsifolia leaf aqueous extract may be used to ‎formulate a new chemotherapeutic drug or supplement to treat the several types of human breast cancer. ‎

Lithocarpus Polystachyus Rehd Leaf Aqueous Extract Inhibits Human Breast Cancer Growth In Vitro and In Vivo

2014 ◽  
Vol 66 (4) ◽  
pp. 613-624 ◽  
Author(s):  
Caiyu Lin ◽  
Li Wang ◽  
Hong Wang ◽  
Shengtao Fang ◽  
Quanbo Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Aqueous Extract ◽  
Human Breast Cancer ◽  
Cancer Growth ◽  
Human Breast ◽  
Leaf Aqueous Extract ◽  
Breast Cancer Growth

scholarly journals Biosynthesis of Fe nanoparticles using Alhagi sparsifolia extract for the treatment of colorectal carcinoma in the in vitro condition: A pre-clinical trial study

2021 ◽  
Author(s):  
Yadong Zhou ◽  
Fafu Dou ◽  
Tahani Awad Alahmadi ◽  
Sulaiman Ali Alharbi ◽  
Milton Wainwright
Keyword(s):  
Colorectal Carcinoma ◽  
Cell Lines ◽  
Aqueous Extract ◽  
Mtt Assay ◽  
Iron Nanoparticles ◽  
Alhagi Sparsifolia ◽  
Leaf Aqueous Extract ◽  
Hct 116 ◽  
Human Colorectal Carcinoma ◽  
Ht 29

IntroductionThe preparation and formulation of new chemotherapeutic supplements and drugs with remarkable effects for the treatment of cancer are in the priority of both developing and developed countries. Recently, iron nanoparticles have been used as modern chemotherapeutic drugs for the treatment of several cancers such as leukemia, lung cancer, breast cancer, prostate cancer, etc. In the present study, iron nanoparticles were green-synthesized using the aqueous extract of Alhagi sparsifolia leaf aqueous extract.Material and methodsThe synthesized FeNPs were characterized by analytical techniques including SEM, TEM, UV-Vis., and FT-IR. The anti-human colorectal carcinoma activity of FeNPs was evaluated using MTT assay. In the cellular and molecular part of the recent study, the treated cells with FeNPs were assessed by MTT assay for 48h about the cytotoxicity and anti-human colorectal carcinoma properties on normal (HUVEC) and colorectal carcinoma cell lines i.e. HT-29, HCT 116, HCT-8, and Ramos.2G6.4C10.ResultsThe nanoparticles were formed in a spherical shape in the average size of 47.24 nm. In the antioxidant test, the IC50 of FeNPs and BHT against DPPH free radicals were 161 and 134 µg/mL, respectively. The viability of malignant colorectal cell line reduced dose-dependently in the presence of FeNPs. The IC50 of FeNPs were 250, 293, 276, and 344 µg/mL against HT-29, HCT 116, HCT-8, and Ramos.2G6.4C10 cell lines, respectively.ConclusionsAfter clinical study, iron nanoparticles containing Alhagi sparsifolia leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat the several types of human colorectal carcinoma.

A Study of Lobular Carcinoma of the Breast Based on the Third National Cancer Survey in the United States of America

1979 ◽  
Vol 65 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Donald Henson ◽  
Robert Tarone
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
The United States ◽  
Incidence Rates ◽  
Carcinoma Of The Breast ◽  
The Third ◽  
Infiltrating Ductal Carcinoma ◽  
Epidemiological Surveys ◽  
Miyagi Prefecture

Cases in in situ and infiltrating lobular carcinoma of the breast reported in the Third National Cancer Survey were reviewed according to age, sex, race, and geographic distribution. The age-specific incidence rates indicate that there are two peak age periods of risk for invasive lobular carcinoma, the first occurring in ages 40-50 years and the second after age 65. The incidence rates for lobular carcinoma were compared to the incidence rates for intraductal and infiltrating ductal carcinoma reported from the Third National Cancer Survey and for total breast cancer from the Miyagi prefecture in Japan. These comparisons indicate that factors which influence the geographic variation in breast cancer play important roles in the etiology of infiltrating ductal carcinoma, but may have little effect upon the incidence of lobular carcinoma and intraductal carcinoma. The limitations of large histological epidemiological surveys are discussed.

scholarly journals Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells

2021 ◽  
Vol 54 (1) ◽  
Author(s):  
Mariam Abdulaziz Alkhateeb ◽  
Wedad Refaiea Al-Otaibi ◽  
Qwait AlGabbani ◽  
Amena Ali Alsakran ◽  
Alaa Ahmed Alnafjan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Low Temperature ◽  
Cancer Cells ◽  
Aqueous Extract ◽  
Breast Cancer Cells ◽  
Mitochondrial Fission ◽  
Ocimum Basilicum ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
The Impact

Abstract Background The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous extract at low temperature (0 °C) mediated mitochondrial fission contributed to induced apoptosis in human breast cancer cells. Methods Fresh blossoms were extracted at low temperature (0 °C) using a watery solvent. Human MCF7 breast cancer cells were then treated with 3 separate fluctuated concentrations of 0, 50, 150 and 250 µg/mL for 24 and 48 h. Results The outcomes demonstrated the presence of anthocyanins, anthraquinones, tannins, reducing sugars, glycosides, proteins, amino acids, flavonoids and volatile oils and nonappearance of Terpinoids and alkaloids. Contrastingly, frail presence of steroids in basil blossoms aqueous concentrate was noted. In addition, the results from a phytochemical subjective examination of basil (Ocimum basilicum L.) blossoms aqueous extract demonstrated that most of the credited natural impacts containing more remarkable contents of antioxidants and anticancer compounds in basil blossoms aqueous extract. Moreover, the restraint of glucose take-up was alleviated mediated by a dose-dependent manner in MCF7 cells with basil (Ocimum basilicum L.) blossoms aqueous extract inducted for 24 h, resulting in mitochondrial fission. Conclusion This is the first study that shows the impact of the aqueous extract of basil (Ocimum basilicum L.) blossoms was extracted at low temperature (0℃/6 h) underlined high amounts of flavonoids and phenolic compounds bearing more anticancer and antioxidant activities compared to another aqueous extract (using boiled water solvent) and alcoholic extracts.

scholarly journals Probing the Antitumor Mechanism of Solanum nigrum L. Aqueous Extract against Human Breast Cancer MCF7 Cells

2019 ◽  
Vol 6 (4) ◽  
pp. 112 ◽  
Author(s):  
Binbing Ling ◽  
Shujun Xiao ◽  
Jinha Yang ◽  
Ying Wei ◽  
Meena K. Sakharkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Aqueous Extract ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Solanum Nigrum ◽  
Pcr Analysis ◽  
Human Breast ◽  
Active Components ◽  
Mcf7 Cells ◽  
Solanum Nigrum L

Solanum nigrum L. is one of the major medicinal plants used to treat cancer. However, the functional mechanism of S. nigrum L. extract is still unknown in spite of numerous studies on its active components. In this study, we probed the potential anticancer mechanism of the aqueous extract of S. nigrum L. (AESN) towards human breast cancer cell line MCF7. At a concentration of 10 g/L, AESN caused 43% cytotoxicity, inhibited the migration, and suppressed the activities of hexokinase and pyruvate kinase by about 30% and 40%, respectively, towards the MCF7 cells. RT2-PCR analysis of a panel of 89 caner-related genes identified 13 upregulated and eight downregulated genes (>2-folds) in MCF7 cells upon AESN treatment. Gene ontology (GO) and functional disease ontology (FunDO) analyses show that the antitumor function of S. nigrum L. involves multiple genes and these genes are shared across other diseases or disorders.

scholarly journals Splenectomy for breast carcinoma diffusely metastatic to the spleen presenting as severe transfusion-dependent anaemia and thrombocytopaenia

2018 ◽  
Vol 11 (1) ◽  
pp. e223453 ◽  
Author(s):  
Rabea Hasadia ◽  
Olga Kazarin ◽  
Orit Sofer ◽  
Katerina Shulman ◽  
Anton Troitsa ◽  
...  
Keyword(s):  
Lobular Carcinoma ◽  
Metastatic Carcinoma ◽  
Severe Anaemia ◽  
Carcinoma Of The Breast ◽  
Patients With Cancer ◽  
Stage Disease ◽  
Symptomatic Anaemia ◽  
Splenic Involvement ◽  
Abdominal Examination ◽  
End Stage

We report a 48-year-old woman with metastatic infiltrating lobular carcinoma of the breast. Though her metastatic disease remained stable, she was repeatedly admitted for symptomatic anaemia and treated by red blood cell and platelet transfusions with increasing frequency as time elapsed. Abdominal examination and ultrasound revealed splenomegaly (27 cm span). A bone marrow biopsy showed fibrosis and foci of metastatic carcinoma. Splenectomy ameliorated her transfusion-dependent anaemia and thrombocytopaenia. Histopathology revealed multiple foci of metastatic carcinoma and scattered foci of extramedullary haematopoiesis. Differential diagnosis of anaemia and thrombocytopaenia in patients with cancer include bone morrow involvement by cancer cells, iron-deficiency anaemia, microangiopathies and chemotherapy suppression of haematopoiesis. Splenic involvement with cancer is common in patients with multivisceral disease. Many may regard transfusion-dependent severe anaemia and thrombocytopaenia as an end-stage disease in these patients. Nevertheless, palliative splenectomy should be considered in patients with possible hypersplenism who will otherwise survive for a relatively prolonged period of time.

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