Effects of Non-periodized and Linear Periodized Combined Exercise Training on Insulin Resistance Indicators in Adults with Obesity: A Randomized Controlled Trial

Background The aim was to verify the effect of non-periodized and linear periodized combined (aerobic plus resistance) exercise training on insulin resistance markers in adults with obesity. Methods A blinded randomized control trial was conducted with three groups of individuals with obesity (BMI, 30–39.9 kg/m2): control group (CG, n = 23), non-periodized group (NG, n = 23), and linear periodized group (PG, n = 23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with a total duration of 60 min each. The aerobic training of the NG had a duration of 30 min always between 50% and 59% of the reserve heart rate (HRres), while resistance exercise was comprised of 6 exercises, performed always in 2 × 10–12 maximum repetitions (MRs). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2 × 12–14 to 2 × 8–10 RM, respectively, along the intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre- and post-intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. Results After 16 weeks of training, per protocol analysis (n = 39) showed significant reductions in HOMA-IR only in the training groups (NG: Δ = − 1.6, PG: Δ = − 0.6; p = 0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: Δ = − 1.4, PG: Δ = − 1.0; p = 0.004) and HOMA-IR (NG: Δ = − 5.5, PG: Δ = − 3.8; p = 0.002). Conclusion Periodized and non-periodized combined exercise training similarly reduces insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019—https://ensaiosclinicos.gov.br/trial/5970/1.

Effects of Nonperiodized and Linear Periodized Combined Exercise Training on Insulin Resistance Indicators in Adults With Obesity: A Randomized Controlled Trial

BackgroundThe aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. MethodsWas conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9kg/m²): control group (CG, n=23), non-periodized group (NG, n=23), and linear periodized group (PG, n=23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50%–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2×10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2×12–14 to 2×8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. ResultsAfter 16 weeks of training, per protocol analysis (n=39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p=0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p=0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p=0.002). ConclusionPeriodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019 - https://ensaiosclinicos.gov.br/trial/5970/1

Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects

Background: Since aging affects the immune responses against vaccination, the present study evaluated the effects of L-glutamine (Gln) supplementation in the humoral and cellular immune responses in elderly subjects, practitioners or not, of physical exercise training. Methods: Eighty-four elderly people (aged 72.6 ± 6.1), non-practitioners (NP, n = 31), and practitioners of combined-exercise training (CET, n = 53) were submitted to Influenza virus vaccination and supplemented with Gln (0.3 g/kg of weight + 10 g of maltodextrin, groups: NP-Gln (n = 14), and CET-Gln (n = 26)), or placebo (10 g of maltodextrin, groups: NP-PL (n = 17), and CET-PL (n = 27)). Blood samples were collected pre (baseline) and 30 days post-vaccination and supplementation. Results: Comparing with the baseline values, whereas the NP-Gln and CET-PL groups showed higher specific-IgM levels, the CET-Gln group showed higher specific-IgM and IgA levels post-vaccination. The titer rate of hemagglutination inhibition was higher in the CET-Gln, NP-PL, and NP-Gln groups post-vaccination than baseline values. The absolute number of naive and effector CD4+ T cells was higher especially in the NP-Gln and CET-Gln groups, whilst activated CD4+ T cells were higher in CET subgroups post-vaccination. Conclusion: Our results showed that both l-glutamine supplementation and combined-exercise training can improve the immune responses to the Influenza virus vaccine in elderly subjects.