scholarly journals Effects of Non-periodized and Linear Periodized Combined Exercise Training on Insulin Resistance Indicators in Adults with Obesity: A Randomized Controlled Trial

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Anne Ribeiro Streb ◽  
Larissa dos Santos Leonel ◽  
Rodrigo Sudatti Delevatti ◽  
Cláudia Regina Cavaglieri ◽  
Giovani Firpo Del Duca
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Total Duration ◽  
Control Group ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Combined Exercise ◽  
Resistance Markers ◽  
Combined Exercise Training

Abstract Background The aim was to verify the effect of non-periodized and linear periodized combined (aerobic plus resistance) exercise training on insulin resistance markers in adults with obesity. Methods A blinded randomized control trial was conducted with three groups of individuals with obesity (BMI, 30–39.9 kg/m2): control group (CG, n = 23), non-periodized group (NG, n = 23), and linear periodized group (PG, n = 23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with a total duration of 60 min each. The aerobic training of the NG had a duration of 30 min always between 50% and 59% of the reserve heart rate (HRres), while resistance exercise was comprised of 6 exercises, performed always in 2 × 10–12 maximum repetitions (MRs). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2 × 12–14 to 2 × 8–10 RM, respectively, along the intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre- and post-intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. Results After 16 weeks of training, per protocol analysis (n = 39) showed significant reductions in HOMA-IR only in the training groups (NG: Δ = − 1.6, PG: Δ = − 0.6; p = 0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: Δ = − 1.4, PG: Δ = − 1.0; p = 0.004) and HOMA-IR (NG: Δ = − 5.5, PG: Δ = − 3.8; p = 0.002). Conclusion Periodized and non-periodized combined exercise training similarly reduces insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019—https://ensaiosclinicos.gov.br/trial/5970/1.

scholarly journals Effects of Nonperiodized and Linear Periodized Combined Exercise Training on Insulin Resistance Indicators in Adults With Obesity: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Anne Ribeiro Streb ◽  
Larissa dos Santos Leonel ◽  
Rodrigo Sudatti Delevatti ◽  
Claudia Regina Cavaglieri ◽  
Giovani Firpo Del Duca
Keyword(s):  
Insulin Resistance ◽  
Randomized Controlled Trial ◽  
Exercise Training ◽  
Controlled Trial ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Combined Exercise ◽  
Randomized Controlled ◽  
Resistance Markers ◽  
Combined Exercise Training

Abstract BackgroundThe aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. MethodsWas conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9kg/m²): control group (CG, n=23), non-periodized group (NG, n=23), and linear periodized group (PG, n=23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50%–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2×10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2×12–14 to 2×8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. ResultsAfter 16 weeks of training, per protocol analysis (n=39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p=0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p=0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p=0.002). ConclusionPeriodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019 - https://ensaiosclinicos.gov.br/trial/5970/1

scholarly journals Effects Of Non-periodized And Linear Periodized Combined Exercise Training On Insulin Resistance Indicators In Adults With Obesity: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Anne Ribeiro Streb ◽  
Larissa dos Santos Leonel ◽  
Rodrigo Sudatti Delevetti ◽  
Claúdia Regina Cavaglieri ◽  
Giovani Firpo Del Duca
Keyword(s):  
Insulin Resistance ◽  
Randomized Controlled Trial ◽  
Exercise Training ◽  
Controlled Trial ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Combined Exercise ◽  
Randomized Controlled ◽  
Resistance Markers ◽  
Combined Exercise Training

Abstract Background The aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. Methods Was conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9 kg/m²): control group (CG, n = 23), non-periodized group (NG, n = 23), and periodized group (PG, n = 23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2 × 10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40–49% to 60–69% (HRres) and from 2 × 12–14 to 2 × 8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. Results After 16 weeks of training, per protocol analysis (n = 39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p = 0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p = 0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p = 0.002). Conclusion Periodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity.

scholarly journals Effect of Eight Weeks of Concurrent Training on Liver Enzymes, Lipid Profile, and Insulin Resistance Among Overweight Male Children

2019 ◽  
Vol 25 (4) ◽  
pp. 312-323
Author(s):  
Shahrirar Khajeh Salehani ◽  
◽  
Rostam Alizadeh ◽  
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Lipid Profile ◽  
Liver Enzymes ◽  
Training Group ◽  
Concurrent Training ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Combined Exercise ◽  
Combined Exercise Training

Aims The aim of this study was to investigate the effect of eight weeks of combined exercise training (aerobic-resistance) on liver enzymes, lipid profile, and insulin resistance among overweight boys. Methods & Materials Thirty-two healthy overweight boys voluntarily agreed to take part in the study following the related announcement. The overweight children were randomly divided into control (n=16) and experimental groups (n=16). The latter group performed Concurrent training for eight weeks, three sessions per week, on non-consecutive days. In the same way as the experimental group, both before and after the eight weeks of training. In similar conditions, measurement were performed for both experimental and control groups in two stages (i.e. pre-test and after eight weeks of training). Findings The results of comparing pre- and post-exercise changes in the values for glucose, insulin, ALT, AST, and insulin resistance for the combined exercise training group showed a significant decrease when compared with those for the control group (p<0.05); however, the LDL and HDL values did not change significantly across groups (p>0.05). Conclusion In general, the results of this study showed that combined exercises (aerobic-resistance), by reducing the rest levels of liver enzymes, glucose, insulin, insulin resistance, and body composition indexes among 11- to 13-year-old boys, tended to be effective in decreasing the risks of being overweight and in preventing such diseases as obesity, diabetes, and non-alcoholic fatty liver disease.

Effects of a Therapeutic Lifestyle Modification Program on Inflammatory Chemokines and Insulin Resistance in Subjects With Metabolic Syndrome

2010 ◽  
Vol 13 (2) ◽  
pp. 182-188 ◽  
Author(s):  
Eui Geum Oh ◽  
Sang Hui Chu ◽  
So Youn Bang ◽  
Mi Kyung Lee ◽  
Soo Hyun Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lifestyle Modification ◽  
Intervention Group ◽  
Retinol Binding Protein ◽  
Control Group ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Short Term ◽  
Inflammatory Chemokines

Background. Although therapeutic lifestyle modification (TLM) effectively improves the values of diagnostic biomarkers of metabolic syndrome, less is known about its effects on inflammatory chemokines and insulin resistance (IR) in patients with this syndrome. Objectives. To examine the effects of a short-term TLM program on inflammatory chemokines (monocyte chemoattractant protein-1 [MCP-1], retinol binding protein-4 [RBP-4]) and IR in subjects with metabolic syndrome. Method. Twenty-nine women (aged 66.5 ± 9.5 years) with metabolic syndrome were randomly assigned to the TLM intervention group (n = 16) or control group (n = 13). The TLM intervention group was provided with 4 weeks of health screening, education, exercise, diet, and counseling. Participants in the control group were instructed to maintain their usual lifestyle behavior. Outcome variables measured included MCP-1, RBP-4, fasting glucose, fasting insulin, and homeostasis model assessment (HOMA). An intention-to-treat strategy was not followed, and the final number of subjects in the analysis was 22 (14 in the TLM group and 8 in the control group). Results. After a 4-week TLM program, MCP-1, fasting insulin, and HOMA were significantly decreased in the TLM group compared to those in the control group (all p < .05). Conclusions. We conclude that a short-term TLM program could be effective for improving inflammatory state and IR, which are significant preceding biomarkers for cardiovascular complications in subjects with metabolic syndrome.

scholarly journals Study of Serum Chemerin in Patients of Polycystic Ovarian Syndrome and its Relation to Insulin Resistance

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M R Halawa ◽  
R S Abdelbaky ◽  
Y M Eid ◽  
M S Nasr ◽  
L M Hendawy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Polycystic Ovarian Syndrome ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Total Testosterone ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Obese Women ◽  
Ovarian Syndrome

Abstract Background study of chemerin level in polycystic ovarian syndrome (PCO) patients and its relation to insulin resistance (IR). Upon chemerin on adipose tissue and glucose metabolism, serum chemerin has been recently studied in (PCO) women Aim We aimed to study the level of serum chemerin in PCO patients and its relation to insulin resistance. Methods The current study included 45 subjects with PCO syndrome and 45 healthy subjects as a control group. PCO subjects were divided into 27 obese PCO and 18 lean PCO. Control women were divided into 25 obese women and 20 lean women. Measurement of serum chemerin levels, fasting blood glucose (FBG),fasting insulin (FIN), total testosterone and pelvic ultrasonography Results Serum chemerin was significantly higher in the obese PCOS group (99.65 ± 13.72 ng/mL) compared with lean PCOS (87.99 ± 5,64 ng/mL) and the obese (76.82 ± 2.39 ng/mL) and non-obese (69.19 ± 8.40 ng/mL) control groups. In PCOS women, serum chemerin levels were positively correlated with Body mass index (BMI) (r = 0.835, P &lt; 0.001), Fasting blood glucose (FBG) (r = 0.493, P &lt; 0.005), Fasting insulin (FIN) (r = 0.913, P &lt; 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.9181, P &lt; 0.001). Conclusion There is an increase in serum chemerin level in PCOS patients with even more significant increase in patients with obese PCOS.

scholarly journals Isoflavone Supplementation Does Not Potentiate the Effect of Combined Exercise Training on Resting and Ambulatory Blood Pressure in Non-Obese Postmenopausal Women: A Randomized Double-Blind Controlled Trial-A Pilot Study

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3495
Author(s):  
Juliene G. C. Dechichi ◽  
Igor M. Mariano ◽  
Jéssica S. Giolo ◽  
Jaqueline P. Batista ◽  
Ana Luiza Amaral ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Diastolic Blood Pressure ◽  
Postmenopausal Women ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Controlled Trial ◽  
Combined Exercise ◽  
Combined Exercise Training

Physical exercise and isoflavone supplementation are potential strategies to prevent and treat cardiovascular diseases in postmenopausal women. The aim of this study was to investigate whether there are additive effects of isoflavone supplementation when associated with combined aerobic and resistance exercise on resting and ambulatory blood pressure monitoring (ABPM) and in blood pressure variability (BPV). Thirty-one non-obese postmenopausal women were randomly allocated into two groups: placebo and exercise (Placebo n = 19); and isoflavone supplementation (100 mg/day) and exercise (isoflavone n = 19). ABPM and BPV were evaluated before and after 10 weeks of moderate combined (aerobic and resistance) exercise training. Generalized Estimating Equation (GEE) with Bonferroni correction and intention-to-treat analysis was used to compare the effects of interventions on resting BP, ABPM and BPV. Combined exercise training decreased resting systolic (SBP) and diastolic blood pressure (DBP) and reduced 24 h and awake ambulatory SBP, DBP and mean blood pressure over time, with no additional effects of isoflavone supplementation. No changes were observed in sleep period, or in BPV indexes (Standard Deviation of 24 h (SD), daytime and nighttime interval (SDdn) and average real variability (ARV) in both groups. We conclude that isoflavone supplementation does not potentiate the effects of combined training on resting and ambulatorial systolic and diastolic blood pressure in non-obese postmenopausal women.

scholarly journals Circulating Omentin-1, Insulin Resistance and Lipid Profile Responses Following an Eight-week Aerobic Training Intervention Among Male Smokers 

2020 ◽  
Author(s):  
Seyed Maysam Mousavi ◽  
Ali Heidarianpour ◽  
Hassan Tavassoli
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Aerobic Exercise Training ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Model Assessment

Abstract Background: Omentin-1 is a recently discovered circulating adipokine that plays a crucial role in modulating insulin resistance and diabetes. We investigated the effect of eight weeks of aerobic exercise training on serum omentin-1, insulin resistance and lipid profile in the smokers and non-smokers with normal weight. Methods: Nineteen male healthy and twenty male smokers were randomly assigned into healthy control group (C), healthy exercise group (E), control smoker group (CS) and exercise smoker group (ES). Exercise groups participated in an eight-week aerobic exercise training program (three times a week, 20-35 min per session at 55%-70% of maximum heart rate). Serum omentin-1 and insulin values were determined by ELISA and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), glucose and lipid profile was measured before and after the intervention. Paired samples t-test, one-way analysis of variance (One-way ANOVA) and post-hoc Tukey test were applied to analyze the data (p<0.05).Results: Aerobic exercise improved both serum omentin-1 and high lipoprotein cholesterol (HDL-C) in the exercise groups (p<0.05). Also, Exercise training reduced insulin, blood sugar, HOMA-IR, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (p<0.05). Omentin-1 was significantly correlated with insulin (r=-0.40, P=0.01), HOMA-IR (r=-0.38, P=0.04), TG (r=-0.40, P=0.01), TC (r=-0.49, P=0.02), LDL-C (r=-0.70, P=0.02) and HDL-C (r=0.55, P=0.03).Conclusion: The findings suggest that aerobic exercise-induced changes in omentin-1 in exercise trained smokers may be associated with the beneficial effects of exercise on reduced insulin resistance and lipid profile.

scholarly journals Lifestyle intervention modifies the effect of the MC4R genotype on changes in insulin resistance among women with prior gestational diabetes: Tianjin Gestational Diabetes Mellitus Prevention Program

2019 ◽  
Vol 110 (3) ◽  
pp. 750-758 ◽  
Author(s):  
Yuhang Chen ◽  
Huikun Liu ◽  
Leishen Wang ◽  
Tao Zhou ◽  
Zhaoxia Liang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lifestyle Intervention ◽  
Prevention Program ◽  
Control Group ◽  
Model Assessment ◽  
Fasting Insulin

ABSTRACTBackgroundA history of gestational diabetes mellitus (GDM) has been related to an elevated risk of type 2 diabetes. The melanocortin-4 receptor (MC4R) genotype has been related to glycemic changes in women with prior GDM.ObjectiveThe objective of this study was to analyze whether lifestyle intervention modified the association between the MC4R genotype and changes in insulin sensitivity among women with prior GDM.MethodsWe genotyped MC4R rs6567160 and measured glucose and insulin in fasting plasma samples at baseline and during the first 2 follow-up visits in 1128 women with prior GDM. They were randomly assigned to either a 4-y lifestyle intervention involving both diet and physical activity or a control group from a randomized clinical trial, the Tianjin Gestational Diabetes Mellitus Prevention Program. We analyzed the interaction between the MC4R genotype and lifestyle intervention on changes in insulin resistance.ResultsFrom baseline to 1.28 y, the MC4R genotype was related to changes in fasting insulin, HOMA-IR, and homeostasis model assessment of β cell function (HOMA-B) in the intervention group. Each risk allele (C) of rs6567160 was associated with a 0.08-unit greater decrease in log(insulin), log(HOMA-IR), and log(HOMA-B) (P = 0.02, 0.04, and 0.04, respectively), whereas in the control group, each C allele tended to be associated with a greater increase in HOMA-IR (P = 0.09). We found significant interactions between the MC4R genotype and lifestyle intervention on 1.28-y changes in fasting insulin and HOMA-IR (P = 0.006 and 0.008, respectively), and such interaction remained significant when we analyzed the trajectory of changes in insulin and HOMA-IR from baseline to 2.55 y (both P = 0.03).ConclusionsThe exploratory results from the first 2 follow-up visits indicate that women with prior GDM carrying a diabetes-increasing MC4R genotype (CC or TC) may obtain better improvement than the TT genotype in insulin resistance through lifestyle intervention. This trial was registered at clinicaltrials.gov as NCT01554358.

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