scholarly journals Effects of Nonperiodized and Linear Periodized Combined Exercise Training on Insulin Resistance Indicators in Adults With Obesity: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Anne Ribeiro Streb ◽  
Larissa dos Santos Leonel ◽  
Rodrigo Sudatti Delevatti ◽  
Claudia Regina Cavaglieri ◽  
Giovani Firpo Del Duca
Keyword(s):  
Insulin Resistance ◽  
Randomized Controlled Trial ◽  
Exercise Training ◽  
Controlled Trial ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Combined Exercise ◽  
Randomized Controlled ◽  
Resistance Markers ◽  
Combined Exercise Training

Abstract BackgroundThe aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. MethodsWas conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9kg/m²): control group (CG, n=23), non-periodized group (NG, n=23), and linear periodized group (PG, n=23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50%–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2×10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2×12–14 to 2×8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. ResultsAfter 16 weeks of training, per protocol analysis (n=39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p=0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p=0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p=0.002). ConclusionPeriodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019 - https://ensaiosclinicos.gov.br/trial/5970/1

scholarly journals Effects Of Non-periodized And Linear Periodized Combined Exercise Training On Insulin Resistance Indicators In Adults With Obesity: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Anne Ribeiro Streb ◽  
Larissa dos Santos Leonel ◽  
Rodrigo Sudatti Delevetti ◽  
Claúdia Regina Cavaglieri ◽  
Giovani Firpo Del Duca
Keyword(s):  
Insulin Resistance ◽  
Randomized Controlled Trial ◽  
Exercise Training ◽  
Controlled Trial ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Combined Exercise ◽  
Randomized Controlled ◽  
Resistance Markers ◽  
Combined Exercise Training

Abstract Background The aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. Methods Was conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9 kg/m²): control group (CG, n = 23), non-periodized group (NG, n = 23), and periodized group (PG, n = 23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2 × 10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40–49% to 60–69% (HRres) and from 2 × 12–14 to 2 × 8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. Results After 16 weeks of training, per protocol analysis (n = 39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p = 0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p = 0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p = 0.002). Conclusion Periodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity.

scholarly journals Effects of Non-periodized and Linear Periodized Combined Exercise Training on Insulin Resistance Indicators in Adults with Obesity: A Randomized Controlled Trial

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Anne Ribeiro Streb ◽  
Larissa dos Santos Leonel ◽  
Rodrigo Sudatti Delevatti ◽  
Cláudia Regina Cavaglieri ◽  
Giovani Firpo Del Duca
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Total Duration ◽  
Control Group ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Combined Exercise ◽  
Resistance Markers ◽  
Combined Exercise Training

Abstract Background The aim was to verify the effect of non-periodized and linear periodized combined (aerobic plus resistance) exercise training on insulin resistance markers in adults with obesity. Methods A blinded randomized control trial was conducted with three groups of individuals with obesity (BMI, 30–39.9 kg/m2): control group (CG, n = 23), non-periodized group (NG, n = 23), and linear periodized group (PG, n = 23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with a total duration of 60 min each. The aerobic training of the NG had a duration of 30 min always between 50% and 59% of the reserve heart rate (HRres), while resistance exercise was comprised of 6 exercises, performed always in 2 × 10–12 maximum repetitions (MRs). The PG progressed the aerobic and resistance training from 40%–49% to 60%–69% (HRres) and from 2 × 12–14 to 2 × 8–10 RM, respectively, along the intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre- and post-intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. Results After 16 weeks of training, per protocol analysis (n = 39) showed significant reductions in HOMA-IR only in the training groups (NG: Δ = − 1.6, PG: Δ = − 0.6; p = 0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: Δ = − 1.4, PG: Δ = − 1.0; p = 0.004) and HOMA-IR (NG: Δ = − 5.5, PG: Δ = − 3.8; p = 0.002). Conclusion Periodized and non-periodized combined exercise training similarly reduces insulin resistance markers in adults with obesity. Trial registration: Brazilian Registry of Clinical Trials, RBR-3c7rt3. Registered 07 February 2019—https://ensaiosclinicos.gov.br/trial/5970/1.

scholarly journals Efficacy of Bushen Huatan Decoction Combined with Baduanjin in the Treatment of Polycystic Ovary Syndrome with Insulin Resistance (IR-PCOS), Kidney Deficiency and Phlegm Dampness: Study Protocol for a Randomized Controlled Trial

2021 ◽  
Author(s):  
Haiqing Qian ◽  
Wenting Xu ◽  
Lijuan Cui ◽  
Rong Wang ◽  
Jiahui Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Randomized Controlled Trial ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Close Monitoring ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Randomized Controlled

Abstract Background: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women. Insulin resistance (IR) has emerged as a central contributor to the pathogenesis of this disease. Traditional Chinese medicine (TCM) involving syndrome differentiation and treatment is widely used to adjust women's menstrual cycles. Our patented formula Bushen Huatan Decoction (BSHTD) has been proven to be effective in the clinical treatment of IR-PCOS. Baduanjin also plays an important role in improving metabolic syndrome through lifestyle intervention. This study investigates the clinical efficacy of Bushen Huatan Decoction combined with Baduanjin in IR-PCOS, to form a specific TCM-behaviour intervention plan in the treatment of IR-PCOS.Methods/design: This is a randomized controlled trial involving 190 participants diagnosed with IR-PCOS. All participants will be randomly allocated into 5 groups: group A will receive metformin; group B, BSHTD; group C, Baduanjin; group D, BSHTD combined with metformin; and group E, BSHTD combined with Baduanjin. One course of treatment lasts three months, a total of two courses. The primary outcomes are changes in the homeostatic model assessment of insulin resistance (HOMA-IR) and improvements in the oral glucose tolerance test (OGTT) and insulin-releasing test (INS). The secondary outcomes are improvements in the menstrual cycle, ovulation rate, clinical pregnancy rate, basic serum sex hormone levels, free androgen index (FAI), Ferriman-Gallwey scores, body mass index (BMI) and TCM syndrome scores. The related observation indexes will be collected at baseline, during the process of treatment and at the 6-months follow-up. Simultaneously, close monitoring of possible adverse events will be performed throughout the trial process.Discussion: This trial will investigate the efficacy of the comprehensive intervention program of Bushen Huatan Decoction combined with Baduanjin on the adjustment of menstrual cycle, improvement of insulin resistance and correction of glucose metabolism disorder in IR-PCOS patients. It is expected to form an alternative treatment of TCM-behavior intervention therapy for IR-PCOS and promote the Chinese fitness Qigong Baduanjin in the application of lifestyle diseases.Trial registration: Chinese Clinical Trial Registry, ChiCTR2100043415. Registered on 15 February,2021.

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