Iron-Catalyzed Homogeneous Hydrogenation with Precise Temperature-Governed Chemoselectivity.

The chemoselective hydrogenation of unsaturated compounds has been a powerful tool for both synthetic chemistry and chemical industry. The achievement of chemoselectivity among different functionalities with a single catalyst has been a challenge for transition metal-catalyzed hydrogenation. In this paper, iron tetraphosphine complexes show high catalytic efficiency for a variety of polar unsaturated substrates such as aldehydes, ketones, enones, nitroarenes and N-heteroaromatics. Without an N-H group on the catalyst, the chemoselectivity was controlled precisely by the reaction temperature. The catalytic efficiency, chemoselectivity and robustness of this Fe/P4N2 catalyst found its merit in the preparation of several important drug intermediates. A diamagnetic trans-iron dihydride complex, formed under the reaction conditions, was supposed to be an on-cycle catalytically active species.<br>

Iron-Catalyzed Homogeneous Hydrogenation with Precise Temperature-Governed Chemoselectivity.

The chemoselective hydrogenation of unsaturated compounds has been a powerful tool for both synthetic chemistry and chemical industry. The achievement of chemoselectivity among different functionalities with a single catalyst has been a challenge for transition metal-catalyzed hydrogenation. In this paper, iron tetraphosphine complexes show high catalytic efficiency for a variety of polar unsaturated substrates such as aldehydes, ketones, enones, nitroarenes and N-heteroaromatics. Without an N-H group on the catalyst, the chemoselectivity was controlled precisely by the reaction temperature. The catalytic efficiency, chemoselectivity and robustness of this Fe/P4N2 catalyst found its merit in the preparation of several important drug intermediates. A diamagnetic trans-iron dihydride complex, formed under the reaction conditions, was supposed to be an on-cycle catalytically active species.<br>

Homogeneous hydrogenation of saturated bicarbonate slurry to formates using multiphase catalysis

Formic acid and formate salts are key intermediates along the pathways for CO2 utilization and hydrogen storage. Herein we report a highly efficient multiphase catalytic system utilizing ruthenium PNP pincer...

Highly Chemoselective Hydrogenation of Cyclic Imides to ω-hydroxylactams or ω-hydroxyamides Catalyzed by Iridium Catalysts

Several novel Ferrocene-based PNN ligands were prepared, which were found as highly effective catalysts (TON up to 50,000) in the homogeneous hydrogenation of cyclic imides with Iridium. The hydrogenation mode...

Enantioselective direct, base-free hydrogenation of ketones by a manganese amido complex of a homochiral, unsymmetrical P-N-P’ ligand

The use of manganese in homogeneous hydrogenation catalysis has been a recent focus in the pursuit of more environmentally benign base metal catalysts. It has great promise with its unique...