One-dimensional elastic wave propagation under quadratic impact loading in a rod with a variable cross section and material distribution is the subject of this study. The material distribution of the problem under investigation as well as the variations of the geometry was elucidated with non-uniform rational B-spline (NURBS). The problem was analyzed employing the isogeometric approach in order to ensure precise modeling of the geometry. The effects of impact loading, cross sectional area, material distribution, and radial inertia on elastic waves were examined in this study. In addition, propagation, reflections, and propagation speed along the axis were investigated. It was observed that the speed was not constant along the axial direction. Also, the cross sectional area had more effect on the amplitude of the elastic wave than the radial inertia. Furthermore, it was concluded that the material distribution and radial inertia may influence the wave propagation speed.