A survey of 3D printing technology applied to paper microfluidics

This critical review describes efforts to apply 3D printing technology to the advancement of paper microfluidic device development.

Paper microfluidics device based colorimetric sensor for the detection and discrimination of elapid versus viper envenomation

Snake bite is a neglected tropical disease-causing mortality and severe damage to various vital organs like nervous system, kidney and heart. To provide a timely and accurate treatment it is...

Automatic flow delay through passive wax valves for paper-based analytical devices

This paper reports the numerical, mathematical, and experimental studies of flow delay through wax valves surrounded by PDMS walls on paper microfluidics.

Enhanced passive mixing for paper microfluidics

Efficient passive mixing can be achieved by contricting the reagent flow using structures having narrow gaps.

Hybrid 3D printed-paper microfluidics

3D printed and paper-based microfluidics are promising formats for applications that require portable miniaturized fluid handling such as point-of-care testing. These two formats deployed in isolation, however, have inherent limitations that hamper their capabilities and versatility. Here, we present the convergence of 3D printed and paper formats into hybrid devices that overcome many of these limitations, while capitalizing on their respective strengths. Hybrid channels were fabricated with no specialized equipment except a commercial 3D printer. Finger-operated reservoirs and valves capable of fully-reversible dispensation and actuation were designed for intuitive operation without equipment or training. Components were then integrated into a versatile multicomponent device capable of dynamic fluid pathing. These results are an early demonstration of how 3D printed and paper microfluidics can be hybridized into versatile lab-on-chip devices.