Inflammatory Breast Carcinoma in a Pre-existing Mammary Hamartoma: A rare case report and Review of Literature

Mammary hamartoma is uncommon typically non-malignant benign breast lesion, comprising varying amounts of fatty, fibrous connective tissue and glandular elements. The co-existence of hamartomas and malignancy is very rare and it has no special propensity to undergo malignant transformation. We present a case report of a 66-year-old patient diagnosed with Inflammatory Breast Carcinoma within a previously diagnosed mammary hamartoma in the right breast. The comprehensive work-up with mammography, ultrasound, Positron Emission Tomography – Computed Tomography (PET-CT) and ultrasound-guided biopsy confirmed invasive ductal carcinoma within the hamartoma. Although malignancy arising within hamartoma is an extremely rare entity, the radiologist should be aware and prudent of the atypical as well as suspicious features within hamartoma during interpretation of imaging modalities and should thoroughly investigate any architectural distortion or microcalcifications within an otherwise typical hamartoma. No case has been reported for inflammatory breast carcinoma in mammary hamartoma as per our best of knowledge.

Relato de Caso de Carcinoma Inflamatório Mamário na Clínica Quatro Patas, Porto Velho, Rondônia, Brasil

Introdução: O carcinoma inflamatório mamário (CIM) é um tumor altamente agressivo que acomete cadelas principalmente na média de 10 anos de idade, é uma neoplasia progressiva e que possui alta taxa de mortalidade. Este trabalho tem por objetivo relatar um caso deferido com suspeita de carcinoma inflamatório mamário. Relato do Caso: Cadela, Sem Raça Definida (SRD), apresentando sinais característicos da patologia supracitada: glândulas mamárias difusamente edemaciadas, doloridas, quente e com pouca demarcação entre os tecidos, região espessa e secreção sero- sanguinolenta. O resultado do exame histopatológico confirmou o diagnóstico, e por infelicidade a doença já se encontrava em estágio avançado. Conclusão: O prognótico era desfavorável, sendo assim, a tutora optou pela eutanásia. Introduction: Inflammatory breast carcinoma is a highly aggressive tumor that attacks female dogs on average ten years of age, is a progressive neoplasm and has a high mortality rate. This work aims to report a suspected case of inflammatory breast carcinoma. Case Report: Female dog, no race defined, showing characteristic signs of the pathology: mammary glands diffusely were swollen, painful, warm and with little demarcation between the tissues, thickened region, and serosanguineous secretion. The result of the histopathological examination confirmed the diagnosis, and unfortunately, the disease was already found in the advanced stage. Conclusion: The prognosis was unfavorable, so the tutor chose euthanasia.