Computational modeling of schedule-specific chemotherapy outcomes in mouse tumor model

Despite the rapid development of new innovative strategies in cancer treatment like immunotherapy, chemotherapy still remains a common choice in many cases. Standard protocols of chemotherapeutic administration rely on a maximal tolerated dose paradigm, however there is growing evidence that this approach is not always optimal. Alternative scheduling, like metronomic - low dose continuous drug administration - were recently proved their efficacy. The space of available variants of drug administration protocols is prohibitively large to be explored empirically, and there is an urgent need of predictive mathematical models for rational chemotherapeutic scheduling design. In this work we tested the ability of the minimal pharmacokinetic-pharmacodynamics model to describe schedule-specific tumor volume time evolution in different mouse tumor models.

Student-to-Student Support in Developmental Mathematics Courses

During the Fall of 2015, faculty and staff at a large community college district with an enrollment of 55,000 in the Southwest United States were encouraged to apply for Innovation Challenge Grants. The goal of these grants was to allow faculty and staff an opportunity to create, innovate, and share ideas, so that the college could strive to be one of the best organizations by developing an environment for students to learn and grow. The funding of this grant came from the district president allowing 5% of the budget from each division to be funneled into a pool of money, from which faculty and staff could apply for a grant. A committee would review each grant request and make recommendations as to whether to approve the funding. For developmental mathematics (DM), a group of three faculty members got together to brainstorm ways these innovation funds could be used to assist students enrolled in DM courses. The meeting focus was directed to students taking weekend DM courses as part of the Weekend College Program. The colleges' Weekend College Program offers alternative scheduling for those unable to attend college during a traditional time frame, desiring to augment a traditional class schedule, or add classes to their day, evening or online schedules.

THE WARSHIP ASSIGNMENT SCHEDULE USING INTEGER PROGRAMMING MODEL

Scheduling is an assignment activity that deals with constraints. A number of events can occur in a period of time and location so that objective functions as close as possible can be fulfilled. In the hierarchy of decision making, scheduling is the last step before the start of an operation. Scheduling warship assignments in Kolinlamil are an interesting topic to discuss and find solutions to using mathematical methods. The process of the Kolinlamil warship assignment schedule was carried out to produce an annual shipbuilding schedule. This process not only requires fast follow-up, but also requires systematic and rigorous steps. Where the assignment schedule is a fairly complex combinatorial problem. While making the assignment schedule that is applied at this time is considered less accurate because it calculates the conventional method. The process of warship assignment schedule in this study using the Integer Programming model aims to obtain alternative scheduling operations. The schedule observed was 13 warships in carrying out N operations for 1 year (52 weeks). This research begins with determining the decision variables and limitations that existing constraints. Hard constraints include: maintenance schedule, time and duration of each task, warship class assigned to the task and the number of executing warships per task. While soft constraints are how long the warship performs its tasks in a row. The mathematical formulation of the Integer Programming model created consists of three indicator, one decision variables, two measuring parameters and five constraint functions. Furthermore, determining the best scheduling alternatives is completed using the Microsoft Exel Solver computing program.Keywords: Scheduling, Integer Programming, Solver.

Aplikasi Penjadwalan Berbasis Heuristik untuk Peserta Pelatihan dengan Waktu dan Materi yang Berbeda-Beda (Heuristic-based Scheduling Application for Trainees with Different Timetables and Courses Material)

Abstrak Sebagian besar lembaga pelatihan atau balai latihan kerja menggunakan penjadwalan dengan model batch, yang artinya sebuah jadwal digunakan bersama-sama untuk sekelompok orang, tanpa melihat karakteristik masing-masing peserta pelatihan atau ketersediaan waktu mereka. Namun penjadwalan model batch seperti itu belum tentu efektif untuk setiap orang dan belum sesuai dengan prinsip student center learning. Tulisan ini menawarkan alternatif solusi bagi lembaga pelatihan atau balai latihan kerja yang memerlukan penjadwalan dengan keragaman materi pelatihan dan ketersediaan waktu setiap peserta yang berbeda-beda. Solusi berupa pembuatan perangkat lunak aplikasi penjadwalan dengan arsitektur model-view-controller. Perangkat lunak yang dibuat mampu menjadwalkan lebih dari 300 peserta pelatihan dengan jumlah instruktur lebih dari 14 orang dan materi pelatihan berjumlah lebih dari 18 macam dengan tingkat kedalaman yang beragam.Kata Kunci : penjadwalan pelatihan, slot waktu dan materi berbeda-beda  Abstract It is common for training institutions or vocational training centers using batch scheduling model, which means that a timetable be used together for a group of people, regardless of their individual needs or their time availabilities. Scheduling in batch model like that was not necessarily effective for every class member and not in accordance with the principle of student center learning. This paper offers an alternative scheduling solution for training institutions or vocational training centers that each participant has special needs in timetable, course interest, and course level. Our solution was implemented by model-view-controller architecture. The software could be used to schedule of more than 300 trainees with more than 14 instructors and more than 18 kinds of training materials.    Keyword : training scheduling, different timetables and course material Â