Lead-like compounds for inhibiting Methionine amino peptidase 2 (MetAP2)

This research aims to find a new approach to deal with cancer, by targeting a protein that controls the growth and increases the size of the tumour. The approach uses computer-aid drug designed to find the best drug for inhibiting f Methionine Aminopeptidase (Metap2) which is an enzyme that is responsible for starting the synthesis of new protein. The inhibition of the enzyme was found to be crucial in stopping the growth of the tumour and its development. In this research, an in-silico approach was conducted to obtain compounds that are capable of inhibiting the enzyme with non-toxic features. This is done by using Ligand-Based. The Zinc15 and National Institute of Cancer Data (NCI) Databases were screened to attain a variety of manufactured Compounds. Then, molecular docking filtration process was carried out using PyRx, and Autodock4. Finally, SwissADME protocol was used to show the ADMET properties and that compounds can permit the blood barriers and validate better pharmacokinetic properties than the Fumagillin.

Design and Realization of Remote Graphic Design System Based on Computer Aid

The traditional remote graphic design system cannot provide users with the basis of design geometry theory, which leads to the disharmony of the design works. For this reason, a computer-aided remote graphic design system is proposed. Determine the image import direction, obtain the contour ratio, compare it with different dynamic rectangle ratios, and give the difference between the image and the standard value and the recommended adjustment value. The experimental results show that the works designed by the design system conform to geometry, are visually harmonious, and the evaluation results are good.

A New Shape Adaptive Motion Control System

In recent years there is a growing trend on integrating Computer Aid Design (CAD), Computer Aid Manufacturing (CAM) and Computer Aided Inspection (CAI). This thesis presents a new shape adaptive motion control system that integrates part measurement with motion control. The proposed system consists of five blocks: surface measurement; surface reconstruction; tool trajectory planning; axis motion control and part alignment In this thesis, the key technology used in surface measurement and surface reconstruction is spatial spectral analysis. In the surface measurement block, a new special spectrum comparison method is proposed to find out an optimal digitizing frequency. In the surface reconstruction block, different interpolation methods are compared in the spatial spectral domain. A spatial spectral B-Spline method is presented. In the tool trajectory planning block, a method is developed to select the motion profile first and then determine the tool locations according to the reconstructed surface in order to improve the accuracy of the planned path. In the part alignment, a three-point alignment method is presented to align the part coordinates with the machine coordinates. Based on the proposed methods, a software package is developed and implemented on the polishing robot constructed at Ryerson University. The effectiveness of the proposed system has been demonstrated by the experiment on edge polishing. In this experiment, the shape of the part edges is measured first, and then constructed as a wire-frame CAD model, based on which tool trajectory is planned to control the tool to polish the edges.

A New Shape Adaptive Motion Control System

In recent years there is a growing trend on integrating Computer Aid Design (CAD), Computer Aid Manufacturing (CAM) and Computer Aided Inspection (CAI). This thesis presents a new shape adaptive motion control system that integrates part measurement with motion control. The proposed system consists of five blocks: surface measurement; surface reconstruction; tool trajectory planning; axis motion control and part alignment In this thesis, the key technology used in surface measurement and surface reconstruction is spatial spectral analysis. In the surface measurement block, a new special spectrum comparison method is proposed to find out an optimal digitizing frequency. In the surface reconstruction block, different interpolation methods are compared in the spatial spectral domain. A spatial spectral B-Spline method is presented. In the tool trajectory planning block, a method is developed to select the motion profile first and then determine the tool locations according to the reconstructed surface in order to improve the accuracy of the planned path. In the part alignment, a three-point alignment method is presented to align the part coordinates with the machine coordinates. Based on the proposed methods, a software package is developed and implemented on the polishing robot constructed at Ryerson University. The effectiveness of the proposed system has been demonstrated by the experiment on edge polishing. In this experiment, the shape of the part edges is measured first, and then constructed as a wire-frame CAD model, based on which tool trajectory is planned to control the tool to polish the edges.