Spatial Structure and Antimicrobial Activity of Cyclopropane Derivative of Limonene

A cyclopropane derivative of limonene, (1 S, 4 S, 6 R)-7,7-dichloro-4-[(1 S)-2,2-dichloro-1-methylcyclopropyl]-1-methylbicyclo [4.1.0] heptane (compound 2), was synthesized and its structure was determined by NMR and X-ray crystallographic methods. In addition, an antimicrobial activity of the compound against Gram-positive ( Staphylococcus aureus, Bacillus subtilis) and Gram-negative ( Escherichia coli, Pseudomonas aeruginosa) bacterial strains was also scrutinized.

Cyclopropane formation under frustrated Lewis pair conditions

Reaction of the –CH2OSiMe3 substituted allyldimesitylphosphane with HB(C6F5)2 resulted in a hydroboration/(C6F5)2BOSiMe3 elimination sequence to give the phosphinomethyl substituted cyclopropane derivative, probably via a phosphiranium type intermediate.

Designed enzymatically degradable amphiphilic conetworks by radical ring-opening polymerization

A simple and versatile route for making functional biodegradable amphiphilic conetworks (APCNs) with unique swelling property and excellent enzymatic degradability is presented. The APCNs were made by radical ring-opening copolymerization of cyclic ketene acetal and vinyl cyclopropane derivative.

Novel synthesis of a highly functionalized cyclopropane derivative

A model study was carried out to explore the feasibility of synthesizing fused tricyclic ring structures containing a C7—C8 double bond juncture (steroid numbering) by employing an SN2' cyclization of a silyl enol ether to displace an allylic acetate as the key step. Instead of the anticipated product, highly functionalized cyclopropanes were obtained. These novel cyclopropane structures are the result of the concomitant 1,2-migration of a dithiane thioether moiety and the eventual displacement of the acetate group, followed by the cyclization of the silyl enol ether.Key words: tricycles, SN2' cyclization, inductive effect, cyclopropane.