There are hundreds of indigenous groups and peoples around the world. Examples are the Australian Aborigines, the North American Indians (Native Americans) of the United States (US) and Canada, and the Māori of New Zealand. Indigenous people often have elevated suicide rates compared with the general population in their countries, and divergent epidemiological characteristics. Social, economic, political, environmental, and historical factors influence Indigenous people’s mental health. In this chapter, the adoption of culture-specific prevention strategies as well as community-based interventions in countries where indigenous peoples live are proposed and discussed, including the importance of involving the tribal leaders in the communities, clergies, and schools, and to sustain the indigenous heritage of the region.